|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nonalcoholic fatty liver disease and aging: Epidemiology to management显示文摘Nonalcoholic fatty liver disease(NAFLD) is common in the elderly, in whom it carries a more substantial burden of hepatic(nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma) and extra-hepatic manifestations and complications(cardiovascular disease, extrahepatic neoplasms) than in younger age groups. Therefore, proper identification and management of this condition is a major task for clinical geriatricians and geriatric hepatologists. In this paper, the epidemiology and pathophysiology of this condition are reviewed, and a full discussion of the link between NAFLD and the aspects that are peculiar to elderly individuals is provided; these aspects include frailty, multimorbidity, polypharmacy and dementia. The proper treatment strategy will have to consider the peculiarities of geriatric patients, so a multidisciplinary approach is mandatory. Non-pharmacological treatment(diet and physical exercise) has to be tailored individually considering the physical limitations of most elderly people and the need for an adequate caloric supply. Similarly, the choice of drug treatment must carefully balance the benefits and risks in terms of adverse events and pharmacological interactions in the common context of both multiple health conditions and polypharmacy. In conclusion, further epidemiological and pathophysiological insight is warranted. More accurate understanding of the molecular mechanisms of geriatric NAFLD will help in identifying the most appropriate diagnostic and therapeutic approach for individual elderly patients. | Marco Bertolotti Amedeo Lonardo Chiara Mussi Enrica Baldelli Elisa Pellegrini Stefano Ballestri Dante Romagnoli Paola Loria | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | Fatty liver,carotid disease and gallstones:A study of age-related associations显示文摘AIM: To evaluate carotid intima-media thickening (IMT) and plaques, gallstone disease (GD) and fatty liver (FL) as a function of age. METHODS: In 449 subjects, FL and carotid disease were assessed ultrasonographically. In a subgroup of 65/449 patients with non-alcoholic fatty liver disease (NAFLD), carotid disease, GD and associated factors were determined. RESULTS: FL of unspecified etiology was more common in younger and GD in older individuals. FL subjects had an increased prevalence of IMT and a decreased prevalence of plaques and manifested carotid disease earlier. Plaques were more common in subjects with GD. Age was an independent predictor of carotid disease outcome and FL was a protective factor for plaques. In NAFLD, there was an inverse correlation between body weight and age and the latter independently predicted carotid findings. CONCLUSION: Cardiovascular risk in patients with FL and NAFLD needs to be assessed as a function of age and body weight. | Amedeo Lonardo Silvia Lombardini Federica Scaglioni Stefano Ballestri Anna Maria Verrone Marco Bertolotti Lucia Carulli Dorval Ganazzi Nicola Carulli Paola Loria | 2006 | World Journal of Gastroenterology2006，12，36： | 14 |
| 3 | 显示文摘 | Cademartiri L Bertolotti J Sapienza R | 2006 | J Phys Chem B2006，110，： | 1 |
| 4 | Numerical and experimental models of post-operative realistic flows in stenosed coronary bypasses 显示文摘 | Deplano V Fuseri J | 2001 | Journal of Biomechanics2001，34，： | 1 |
| 5 | Three-dimensional numerical simulations of flow through a stenosed coronary bypass 显示文摘 | Deplano V | 2000 | Journal of Biomechanics2000，33，： | 1 |
| 6 | Increased sensitivity to dextran sodium sulfate colitis in IRElbeta-deficient mice显示文摘 | Bertolotti A Wang X Novoa I | 2001 | J Clin Invest2001，107，： | 1 |
| 7 | Reversing-front interferometer for phase-correlation measurements in the turbulent atmosphere显示文摘 | BERTOLOTTI M CARNEVALE M MUZII L | 1970 | Appl Opt1970，9，2： | 1 |
| 8 | A real-time and self-calibrating algorithm based on triaxialaccelerometer signals for the detection of human postureand activity显示文摘 | CURONE Davide BERTOLOTTI Gian Mario | 2010 | IEEE Transactions on InformationTechnology in Biomedicine2010，14，4： | 1 |
| 9 | Linear and nonlinear stability of the blasius boundary layers显示文摘 | Bertolotti F P Herbert T Spalart P R | 1992 | J Fluid Mech1992，242，： | 1 |
| 10 | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1显示文摘 | Urano F Wang X Bertolotti A | 2000 | Science2000，287，5453： | 1 |
| 11 | Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response显示文摘 | Bertolotti A Zhang YL Harding H | 2000 | Nat Cell Biol2000，2，6： | 1 |
| 12 | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE I 显示文摘 | Urano F Wang X Bertolotti A | 2000 | Science2000，287，5453： | 1 |
| 13 | Multi - year evolutionary dynamics og West Nile virus in suburban Chicago, USA, 2005 - 2007显示文摘 | Amore G Bertolotti L Hamer GL | 2010 | Phil Trans R Soc B2010，365，1548： | 1 |
| 14 | Influence of multiple steno?sis on Echo-Doppler functional diagnosis of peripheral arterial dis?ease: A numerical and experimental study显示文摘 | Bertolotti C Qin Z Lamontagne B | 2006 | Ann Biomed Eng2006，34，4： | 1 |
| 15 | Linear and no- nelinear stability of the Blasius boundary 显示文摘 | Bertolotti F P Herbert T Sparlart P R | 1992 | Journal of Fluid Mechanics1992，242，： | 1 |
| 16 | Perk is essential for translational regulation and cell survival during the unfolded protein response 显示文摘 | Harding HP Zhang Y Bertolotti A | 2000 | Mol Cell2000，5，5： | 1 |
| 17 | Three-dimensional numerical simulations of flow through a stenosed coronary bypass显示文摘 | Bertolotti C Deplano V | 2000 | Journal of Biomechanics2000，33，： | 1 |
| 18 | Valuing Intellectual Property显示文摘 | Bertolotti N | 1995 | Managing Intellectual Property1995，，2： | 1 |
| 19 | Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response显示文摘 | Bertolotti A Zhang Y Hendershot LM | 2000 | Nat Cell Biol2000，2，6： | 1 |
| 20 | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IREI显示文摘 | Urano F Wang X Bertolotti A | 2000 | Science2000，287，5453： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员