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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | A simple general synthesis of 1-alkynyldiisop ropoxyboranes 显示文摘 | Brown H C Bhat N G Srebnik M | 1988 | Tetrahedron Letters1988，29，22： | 1 |
| 3 | The protein data bank显示文摘 | Berman H M Westbrook J Feng Z K Gilliland G Bhat T N Weissig H Shindyalov L N Bourne P E | | 0，，01： | 1 |
| 4 | Preferential induction of cytochrome P4501A1 over cytochrome P4501B1 in human breast epithelial cells following exposure to quercetin显示文摘 | Mense S M Chhabra J Bhat H K | 2008 | J Steroid Biochem Mol Biol2008，110，12： | 1 |
| 5 | Microwave synthesis of electrode materials for lithium batteries 显示文摘 | BHAT M H CHAKILAVARTHY B P RAMAKRISHNAN P A LEVASSEUR RAO J | 2000 | Bulletin of Materials Science2000，23，6： | 1 |
| 6 | Identification of failure modes in GFRP using PDVF sensors:ANN approach显示文摘 | H N Bar M R Bhat | 2004 | Composite Structures2004，65，： | 1 |
| 7 | Characterization of chemical vapor deposited HfN multilayer coatings on cemented carbide cutting tools显示文摘 | Staia M H Bhat DG Puchi-Cabrera ES | 2006 | Wear2006，261，5： | 1 |
| 8 | Nickel induced crystallization of amorphous silicon thin films显示文摘 | JIN Z H BHAT G A YEUNG M | 1998 | J Appl Phys1998，84，1： | 1 |
| 9 | Potential of zeolite supported rhodium catalysts for the CO2 reforming of CH4显示文摘 | Sachtler W M H Bhat R N | 1997 | Appl Catal1997，150，2： | 1 |
| 10 | Properties and Performance of Commercial TiCN Coatings显示文摘 | Bull S J Bhat D G Staia M H | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 11 | 显示文摘 | Rao T V Bhat M V Sastry D H | 1996 | British Corrosion Journal1996，31，1： | 1 |
| 12 | Properties and Performance of Commercial TiCN Coatings显示文摘 | Bull S J Bhat D G Staia M H | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 13 | Properties and pefformance of commercial TiCN coatings:coating architecture and hardness modeling显示文摘 | Bhat D G Staia M H | 2003 | Surface and Coating Technology2003，，163164： | 1 |
| 14 | Mechanical and tribological properties of compositionally graded CrAlN films deposited by AC reactive mangnetron sputtering 显示文摘 | Pulugurtha S R Bhat D G Gordon M H | 2007 | Surface and Coatings Technology2007，202，： | 1 |
| 15 | An observer theory for time delay systems 显示文摘 | BHAT K P M KOIVO H N | 1976 | IEEE Transactions on Automatic Control1976，21，： | 1 |
| 16 | Bamboo fibre re- inforced bioeomposites~ A review 显示文摘 | Abdul Khali H P S Bhat I U H Jawaid M | 2012 | Materials and Design2012，，42： | 1 |
| 17 | Mechanical and Tribological Properties of Compositionally Graded CrA1N Films Deposited by AC Reactive Magnetron Sputtering显示文摘 | Pulugurtha S R Bhat D G Gordon M H | 2007 | Surface & Coatings Technology2007，202，： | 1 |
| 18 | Effect of harvest dates,preharvest calcium sprays and storage period on physico-chemical characteristics of pear显示文摘 | Bhat M Y Ahsan H Banday F A | 2012 | Agric Res Dev2012，2，4： | 1 |
| 19 | Bamboofiber reinforced biocomposites: A review 显示文摘 | Abdul H P S Bhat I U H Jawaid M | 2012 | Materialsand Design2012，42，： | 1 |
| 20 | Properties and performance of commercial TiCN coatings 显示文摘 | Bull S J Bhat D G Staia M H | 2003 | Surface and Coatings Technology2003，，： | 1 |
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