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| 1 | Downregulation of lncRNA AFAP1-AS1 by oridonin inhibits the epithelial-to-mesenchymal transition and proliferation of pancreatic cancer cells显示文摘Recent studies have demonstrated that the expression of the long non-coding RNA(lncRNA)AFAP1-AS1 in pancreatic cancer is negatively correlated with survival and prognosis.However,the effects of oridonin and lncRNA AFAP1-AS1 on the epithelial-to-mesenchymal transition(EMT)and migration of pancreatic cancer cells have not been fully elucidated.Surgery is the only potentially curative method for pancreatic cancer,but postoperative recurrence and metastasis are common.The aim of the present study was to assess the effect of oridonin and lncRNA AFAP1-AS1 silencing on pancreatic cancer cells.The pancreatic cancer cell lines BxPC-3 and PANC-1 cells were transfected with siAFAP1-AS1 and its negative control(siNC).After that,oridonin was used to treat the siAFAP1-AS1-transfected cells.The expression of lncRNA AFAP1-AS1 was downregulated in the pancreatic cancer cell lines BxPC-3 and PANC-1.The apoptosis and cell cycle progression of pancreatic cancer cells were evaluated by flow cytometry and Hoechst 33258 staining.Metastasis and invasion of BxPC-3 and PANC-1 cells were detected by transwell migration assay,real-time cell analysis,and western blot analysis.Cells were transfected with the lentiviral siAFAP1-AS1 and siNC,and tumorigenesis was evaluated in BALB/C nude mice.Immunohistochemical examination was used to verify the effects of oridonin and siAFAP1-AS1 on pancreatic cancer.The results demonstrated that the combination of oridonin and siAFAP1-AS1 inhibited pancreatic cancer cell proliferation,induced apoptosis,arrested cell cycle progression,prevented the migration,regulated EMT-related protein expression in BxPC-3 and PANC-1 cells,and inhibited pancreatic cancer cell tumorigenicity and EMT in nude mice. | Songmei Lou Jian Xu Bili Wang Shuquan Li Jun Ren Zhengjun Hu Bin Xu Feng Luo | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 10 |
| 2 | Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis显示文摘Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. | Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 3 |
| 3 | Elevated serum values of procollagen Ⅲ peptide (PIIIP)in patients with ulcerative colitis who will develop pseudopolyps显示文摘AIM: To assess the impact of procollagen Ⅲ peptide as a marker of collagenesis in the development of pseudopolyps in patients with ulcerative colitis.METHODS: Development of pseudopolyps was monitored in 25 patients with ulcerative colitis classified according to Powell-Tuck index as mild (n=12) or moderate (n=13) form of disease. Patients with a mild form of disease were treated with oral mesalazine medication (2-4 g/day) and local mesalazine preparation (suppository). Patients with a moderate form of disease received oral mesalazine medication (2-4 g/day), local mesalazine preparation(suppository) and local methylprednisolone at an initial dose of 60 rag/day, followed by dose tapering. How many significant variables (previously determined by analysis of variance) were elevated in the groups with and without pseudopolyp developement was observed. ROC analysis for calculation of new index was made.RESULTS: Serum values of procollagen Ⅲ peptide (PⅢP), C-reactive protein (CRP) and C4 complement component (C4)were statistically significantly lower in the group of patients flee from pseudopolyp development bhan bhose who developed one or more pseudopolyps (0.45±0.12 vs 1.42±0.70,P<0.0027; 7.6±4.7 vs 17.8±9.17, P<0.035, and 0.46±0.11 vs 0.34±0.16, P<0.068, respectively) at endoscopic conrtrols with patohistologically samples during 13 months. There were no statistically significant differences in the values of C3, ceruloplasmin and IgM between the two groups (P>0.05).Discrimination function analysis yielded highest standardized cannon coefficients for PⅢP (0.876), CRP (0.104), C3 (-0.534) and C4 (0.184) (P<0.036). The elevation in two of three laboratory variables (PⅢP, CRP and C4) reached sensitivity of 93 % and specificity of 90 % in the development of pseudopolyps.CONCLUSION: It is proposed that an increase in two of the three laboratory parameters (PⅢP, CRP and C4) could improve the accuracy of prediction of the development of pseudopolyps. When using PⅢP, CRP and C4 on decision making, the positive predictive value and accuracy were 90 % and 92 %, respectively. | ■arko Babi Vjekoslav Jagi Zvonko Petrovi Ante Bili KapetanoviDinko Goranka Kubat Rosana Troskot Mira Vukeli | 2003 | World Journal of Gastroenterology2003，9，3： | 2 |
| 4 | Influence of exercise training on left ventricular diastolic function and its relationship to exercise capacity in patients after myocardial infarction显示文摘 | Korzeniowska-Kubacka I Bili fi ska M Michalak E | 2010 | Acta literaria2010，17，2： | 1 |
| 5 | The effect of p2-agonistpatch(especially tulobuterol) 显示文摘 | TIANCH WANXY BILY | 2003 | 日本医学介绍2003，24，10： | 1 |
| 6 | Prenatal diagnosis of common aneuploidies using quantitative fluorescent PCR显示文摘 | Bili C Divane A Apessos A | 2002 | Prenat Diagn2002，22，5： | 1 |
| 7 | Pectoralis major myocutaneous flap in the reconstructive surgery of the head and neck-our experience显示文摘 | Pudes M BiliE M Jurlina M et aI | 2012 | Col/ Antropol2012，36，2： | 1 |
| 8 | Diabetes mellitus risk in rheumatoid arthritis:reduced incidence with anti-tumor necrosis factor α therapy显示文摘 | Antohe JL Bili A Sartorius JA | 2012 | Arthritis Care Res(Hoboken)2012，64，2： | 1 |
| 9 | Metabolism of flavone C-glucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats显示文摘 | Xiaowei Tie Bili Bao | 2007 | British Journal of Nutrition2007，97，： | 1 |
| 10 | Gonadotropin-releasing hor- mone antagonist:impact of IVF practice and poten- tial non - assisted reproductive technology nappli- cations显示文摘 | Tarlatzis B C Bili H N | 2003 | Curt opin Obstet Gyneeol2003，15，3： | 1 |
| 11 | Hydrocarbon oxidation by homogeneous and heterogeneous non-heine iron(Ⅲ)catalysts with H2O2显示文摘 | G Bilis K C Christoforidis Y Deligiannakis | | 0，，： | 1 |
| 12 | Application of shelf life modelling of chilled salad products to a TTI based distribution and stock rotation system显示文摘 | TAOUKIS P S BILI M GIANNAKOUROU M | 1998 | Acta Horticulturae1998，476，： | 1 |
| 13 | Gonadotropin - releasing hormone antago- nists : impact of IVF practice and potential non - assisted reproduc- tive technology applications 显示文摘 | Tarlatzis BC Bili HN | 2003 | Current Opinion in Obstetrics & Gynecology2003，15，3： | 1 |
| 14 | Interaction between Leydig and sertoil cells in vitro显示文摘 | Bilińska B | 1989 | Cytobios1989，60，241： | 1 |
| 15 | Application of shelf life modeling of chilled salad products to a TTI based distribution and stock rotation system显示文摘 | TAOUKIS P S BILI M GIANNAKOUROU M | 1998 | Acta Horticulturae1998，476，： | 1 |
| 16 | Gonadotropin-releasing hormone antagonists: impact of IVF practice and potential non-assisted reproductive technology applications 显示文摘 | Tarlatzis BC Bili HN | 2003 | Curr Opin Obstet Gynecol2003，15，3： | 1 |
| 17 | The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis 显示文摘 | Revilla-I-Domingo R Bilie i Vilagos B | 2012 | EMBO J2012，31，14： | 1 |
| 18 | Mosaic ring X chromosome in a case of secondary amenorrhea 显示文摘 | Chrisoulidou A Bili H Georgiou E | 2008 | Fertil Steril2008，，： | 1 |
| 19 | Hysteresis energy of cyclic loading显示文摘 | Kliman V Bily M | 1984 | Mater Sci Eng A1984，68，1： | 1 |
| 20 | Age related differences in features associated with polyeystie ovary syndrome in normogonadotrophic oligoamenorrhoeie infertile women of reproductive years 显示文摘 | Bili H Laven J Imani B | 2001 | Err J Endocrinol2001，145，4： | 1 |
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