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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 3 | Alkali -activated fly ashes A cement for the future 显示文摘 | PALOMO A GRUTZECK M W BLANCO M T | 1999 | Cem Concr Res1999，29，8： | 2 |
| 4 | Long-term results and survival rate of implants treated with guided bone regeneration: a 5-year case series prospective study显示文摘 | Blanco J Alonso A Sanz M | 2005 | Clin Oral hnplants Res2005，16，3： | 1 |
| 5 | Microemulsion Dynamics and Reactions in Microemulsions显示文摘 | M A Lo'pez-Quimela C Tojo M C Blanco | 2004 | Current Opinion in Colloid and Interface Science2004，9，34： | 1 |
| 6 | Molybdophoric acid adsorption on titania from ethanol-water solutions显示文摘 | CONCELLON A VAZQUEZ P BLANCO M | 1998 | Colloid and Inter Sci1998，204，2： | 1 |
| 7 | Effect of Moxibustion at Acupoints Ren-12 (Zhongwan),St-25 (Tianshu),and St-36 (Zuzanli) in the Prevention of Gastric Lesions Induced by Indomethacin in Wistar Rats显示文摘 | Freire A O Sugai G C Blanco M M | | 0，，02： | 1 |
| 8 | Subacute combined degeneration of the spinal cord: MR findings显示文摘 | Penas M Blanco A Villarejo A | 2002 | Neurologia2002，17，8： | 1 |
| 9 | Computing the solar vector显示文摘 | Blanco M M Padilla A D C Moratalla L T | 2001 | Solar Energy2001，70，5： | 1 |
| 10 | Magnetostriction in glass-coated magnetic microwires 显示文摘 | Zhukov A Zhukova V Blanco J M | 2003 | J Magn Magn Mater2003，258，： | 1 |
| 11 | Tandem DNA recognition by PhoB, a two - component signal transduction transcriptional activator显示文摘 | BLANCO A G SOLA M GOMIS - RUTH F X | 2002 | Structure (Camb)2002，10，5： | 1 |
| 12 | Speciation of mercuty by capillary electrophoresis -inductively coupled plasa mass spectrometry显示文摘 | DA-ROCHA S M SOLDADO A B BLANCO -GONZALEZ E | 2000 | Biomed Chromatogr2000，14，： | 1 |
| 13 | Distribution and characterization of faecal necrotoxigenic Escherichia coli CNFI+ and CNF2+ isolated from healthy cows and calves显示文摘 | BLANCO M BLANCO J E MORA A | 1998 | Veterinary Microbiology1998，59，： | 1 |
| 14 | Analysis of prognostic factors associated with longitudinally extensive transverse myelitis显示文摘 | Sepfllveda M Blanco Y Rovira A | 2013 | Mult Scler2013，19，： | 1 |
| 15 | Magnetostriction in glass-coated magnetic microwires 显示文摘 | Zhukov A Zhukova V Blanco J M | 2003 | J Magn Magn Mater2003，258，： | 1 |
| 16 | Asymmetric Torsion Stress Giant Magneto-impedance in Nearly Zero Magneto-strictive Amorphous Wires 显示文摘 | Blanco J M Zhukov A Gonzalez J | 2000 | J Appl Phys2000，87，： | 1 |
| 17 | Genetic varia- bility in the endophytic fungus Guiguardia eitriearpa isolated from citrus plants显示文摘 | BLANCO G C VILDOSO A C I VIEIRA M L C | 2002 | Genet Mol Biol2002，25，2： | 1 |
| 18 | Alkali -activated-A cement for the future显示文摘 | Palomo A Grutzech M W Blanco M T | 1999 | cement and concrete research1999，29，8： | 1 |
| 19 | Speciation of mercury using capillary electrophoresis coupled to volatile species generation-inductively coupled plasma mass spectrometry 显示文摘 | ROCHA M S SOLDADO A B BLANCO E | 2001 | J Anal At Spectom2001，，16： | 1 |
| 20 | Controlling individual steps in the production process of paracetamol tablets by use of NIR spectroscopy显示文摘 | Blanco M Cueva-Mestanza R Peguero A | 2010 | J Pharm Biomed Anal2010，51，4： | 1 |
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