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| 1 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 2 | Fungicidal activity of ce-cropin A显示文摘 | Delucca A Bland J M Jacks T J | 1997 | Antimicro Agents Chemo1997，41，2： | 2 |
| 3 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 4 | Magnetism in Uhrathin Film Structures显示文摘 | Vaz C A F Bland J A C Lauhoff G | 2008 | Rep Prog Phys2008，71，05： | 1 |
| 5 | Effect of feeding tuna oil or soybean oil as supplements to sows in late pregnancy on piglet tissue composition and piglet Viability显示文摘 | Rooke J A Bland I M Edwards S A | 1998 | British Journal of Nutrition1998，80，： | 1 |
| 6 | Progesterone Administration after Trauma and Hemorrhagic Shock Improves Cardiovascular Responses显示文摘 | KUEBLER J F JARRAR D BLAND K I | 2003 | Cirt Care Mid2003，31，： | 1 |
| 7 | Initial/final state selection of the spin polarization in electron tunneling across an epitaxial Fe/GaA(OOI) interface显示文摘 | KUREBAYASHI H STEINMULLER S J LALOE J B TRYPINIOTIS T EASTON S IONESCU A YATES J R BLAND J A C | 2007 | Appl Phys Lett2007，91，10： | 1 |
| 8 | Statistical Methods for AssessingAgreement between Two Methods of Clinical Measurement 显示文摘 | Martin Bland J Douglas G Altman | 2010 | In-ternational Journal of Nursing Studies2010，47，8： | 1 |
| 9 | Agreed statistics: measurement method comparison显示文摘 | BLAND J M ALTMAN D G | 2012 | Anesthesiology2012，116，1： | 1 |
| 10 | The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily显示文摘 | KINGSLEY D M BLAND A E GRUBBER J M | 1992 | Cell1992，71，： | 1 |
| 11 | Protecting the world's children: the story of WHO's immunization programme 显示文摘 | Bland J Clements J | 1997 | World Health Forum1997，1，： | 1 |
| 12 | From Plants to Birds:Higher Avian Predation Rates in Trees Responding to Insect Herbivory 显示文摘 | MANTYLA E ALESSIO G A BLANDE J D | 2008 | PLoS 0NE2008，3，7： | 1 |
| 13 | Estrogen-induced activa- tion of Erk-1 and Erk-2 requires the G protein-coupled receptor homo- log, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF 显示文摘 | Filardo E J Quinn J A Bland K l | 2000 | Mol Endocrinol2000，14，10： | 1 |
| 14 | Production of taxalor txaol likecompounds in all calture 显示文摘 | Christen A A Gibson D M Bland J | 1991 | US Patent1991，50，： | 1 |
| 15 | Statistical methods for assessing agreement between two methods of clinical measurement 显示文摘 | BLAND J M ALTMAN D G | 1986 | Thelancet1986，，： | 1 |
| 16 | Cross national epi- demiology of major depression and bipolar disorder 显示文摘 | Weissman M M Bland R C Canino G J | 1996 | JAMA1996，276，4： | 1 |
| 17 | Endovascular versus surgi- cal treatment in patients with carotid stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a randomised trial 显示文摘 | Brown MM Rogers J Bland JM | 2001 | Lancet2001，357，9270： | 1 |
| 18 | High glucose up-regulates ENaC and SGK1 expression in HCD-cells显示文摘 | Hills CE Bland R Bennett J | 2006 | Cell PhysiolBiochem2006，18，6： | 1 |
| 19 | The association of depressive syrup - toms and urinary incontinence among older adults 显示文摘 | Dugan E Cohen S J Bland DR | 2000 | J Am Geriatr Soc2000，48，： | 1 |
| 20 | Oxidants and antioxidants in clinical medicine:Past,presentand future potential 显示文摘 | BLAND J S | 1995 | Journal of Nutritional and Environment Medi- cine1995，5，3： | 1 |
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