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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Direct, complex effects of estrogens on basal forebrain cholinergic neurons 显示文摘 | Bora S H Liu Z Kecojevic A | 2005 | Exp Neurol2005，194，2： | 1 |
| 3 | Coronary intervention for acute coronary syndrome in a 51 -year-old man with immune thrombocytope- nic purpura: a case report显示文摘 | Bora D Meltem A Fadime B | 2014 | J Med Case Rep2014，8，： | 1 |
| 4 | Synchronous generator model identification and parameter estimation from operating data显示文摘 | Bora H Karayaka Keyhani A | 2003 | IEEE Transactions on Energy Conversion2003，18，1： | 1 |
| 5 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Maria I. Bellissimo Débora Amado Dulcinéia S.P. Abdalla Edimar C. Ferreira Esper A. Cavalheiro Maria da Gra?a Naffah-Mazzacoratti | 2001 | Epilepsy Research2001，，2： | 1 |
| 6 | A natural analog of res- veratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines 显示文摘 | FREYA W ANTJE C BORA A | 2002 | J Nutr2002，132，2： | 1 |
| 7 | Intravitreal allibercept injection and photodynamic treatment of a patient with unilateral subretinal neo- vascular membrane associated with fundus flavimaculatus 显示文摘 | Ali S Ziya A Bora Y | 2015 | Ophthalmol Med2015，15，2： | 1 |
| 8 | Direct,complex effects of estrogens on asal forebrain cholinergic neurons 显示文摘 | Bora SH Liu Z Kecojevic A | 2005 | Exp Neurol2005，194，2： | 1 |
| 9 | Plasmodium -vivax:Sequence polymorphism and effect of natural selection at apical membrane antigen 1(PvAMAl) among Indian population显示文摘 | Thakur A Alam MT Bora H | 2008 | Gene2008，419，12： | 1 |
| 10 | Functional properties of peptides obtained from whey proteins by ficin extract hydrolysis显示文摘Enzymatic whey proteins concentrates (WPC) hydrolysis under optimal conditions of ficin crude extract (FCE) in two ratios E/S (0.5 and 1%) was studied,assessing the impact of hydrolysis on WPC by determination degree of hydrolysis (DH),Fast proteins liquid chromatography (FPLC),Tricine SDS-PAGE,antioxidant activity at sampling time beside,and technological properties (solubility,emulsifying activity index (EAI) and foaming activity (FA)) at the best condition (maximum DH and antioxidant activity) other side.Results showed,in the first 30 min,DH reached 22.76% at E/S (1%) with a total degradation of α-lactalbumin (α-La) and almost of β-lactoglobulin (β-Lg).A significant increase in antioxidant activity and solubility was observed,while not for EAI,and FA.These results indicate for the first time that β-Lg is susceptible to hydrolyse by FCE that rarely found for other enzymes.Ficin hydrolysates showed very relevant performance,and suggest that could be appropriate production of functional ingredients. | Afaf Kheroufi María E.Brassesco Débora A.Campos Halima Boughellout Manuela E.Pintado | 2022 | Food Bioscience2022，47，3： | 1 |
| 11 | Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion显示文摘AIM: To evaluate changes in neurotransmission induced by a psychoactive beverage ayahuasca in the hippocampus and amygdala of naive rats. METHODS: The level of monoamines, their main metabolites and amino acid neurotransmitters concentrations were quantified using high performance liquid chromatography(HPLC). Four groups of rats were employed: saline-treated and rats receiving 250, 500 and 800 mg/kg of ayahuasca infusion(gavage). Animals were killed 40 min after drug ingestion and the structures stored at-80 ℃ until HPLC assay. The data from all groups were compared using Analysis of variance and Scheffé as post test and P < 0.05 was accepted as significant. RESULTS: The results showed decreased concentrations of glycine(GLY)(0.13 ± 0.03 vs 0.29 ± 0.07, P < 0.001) and γ-aminobutyric acid(GABA)(1.07 ± 0.14 vs 1.73 ± 0.25, P < 0.001) in the amygdala of rats that received 500 of ayahuasca. Animals that ingested 800 mg/kg of ayahuasca also showed a reduction of GLY level(0.11 ± 0.01 vs 0.29 ± 0.07, P < 0.001) and GABA(0.98 ± 0.06 vs 1.73 ± 0.25, P < 0.001). In the hippocampus, increased GABA levels were found in rats that received all ayahuasca doses: 250 mg/kg(1.29 ± 0.19 vs 0.84 ± 0.21, P < 0.05); 500 mg/kg(2.23 ± 038 vs 084 ± 0.21, P < 0.05) and 800 mg/kg(1.98 ± 0.92 vs 0.84 ± 0.21, P < 0.05). In addition, an increased utilization rate of all monoamines was found in the amygdala after ayahuasca administration in doses: 250 mg/kg(noradrenaline: 0.16 ± 0.02 vs 0.36 ± 0.06, P < 0.01; dopamine: 0.39 ± 0.012 vs 2.39 ± 0.84, P < 0.001; serotonin: 1.02 ± 0.22 vs 4.04 ± 0.91, P < 0.001), 500 mg/kg(noradrenaline: 0.08 ± 0.02 vs 0.36 ± 0.06, P < 0.001; dopamine: 0.33 ± 0.19 vs 2.39 ± 0.84, P < 0.001; serotonin: 0.59 ± 0.08 vs 4.04 ± 0.91, P < 0.001) and 800 mg/kg(noradrenaline: 0.16 ± 0.04 vs 0.36 ± 0.06, P < 0.001; dopamine: 0.84 ± 0.65 vs2.39 ± 0.84, P < 0.05; serotonin: 0.36 ± 0.02 vs 4.04 ± 0.91, P < 0.001). CONCLUSION: Our data suggest increased release of inhibitory amino acids by the hippocampus and an increased utilization rate of monoamines by the amygdala after different doses of ayahuasca ingestion. | Eduardo Ferreira de Castro-Neto Rafael Henrique da Cunha Dartiu Xavier da Silveira Mauricio Yonamine Telma Luciana Furtado Gouveia Esper Abr o Cavalheiro Débora Amado Maria da Gra a Naffah-Mazzacoratti | 2013 | World Journal of Biological Chemistry2013，4，4： | 1 |
| 12 | Public Service Broadcasting By Radio: Challenges Ahead显示文摘 | BORA A | 2011 | New Media and Mass Communication2011，，06： | 1 |
| 13 | White matter microstruc- turein opiate addiction显示文摘 | Bora E Yucel M Fornito A | 2012 | Addict Biol2012，17，1： | 1 |
| 14 | Voxelwise meta - analysis of gray matter abnormalities in bipolar disorder显示文摘 | Bora E Fomito A Yucel M | 2010 | Biol Psychiatry2010，67，11： | 1 |
| 15 | Assessment of liver volume with computed tomography and comparison of findings with ultrasonogra- phy显示文摘 | Bora A Alptekin C Yavuz A | 2014 | Abdom Imaging2014，39，6： | 1 |
| 16 | Computer - aided process planning for turned parts using fundamental and heuristic principles显示文摘 | U P Korde B C Bora K A Stelson | 1992 | Journal of Engineering for Industry Transactions of the ASME1992，114，2： | 1 |
| 17 | Antagonistic effect of Tri- choderma viride, Trichoderam harzianum and Aspergillus terreus on Rhizoctonia solani causing sheath blight of rice显示文摘 | BHUYAN S A DAS B C BORA L C | 1994 | Journal of Ag- ricultural Science Society of North East India1994，7，1： | 1 |
| 18 | Reactive extraction of 6- Aminopenicillanic acid with Aliquat-336:Equilibrium and Kinetics 显示文摘 | Bora M M Ghosh A C DUTYA N N | 1997 | The Canadian Journal of Chemical Engineering1997，75，6： | 1 |
| 19 | Isserum human chorionic gonadotrophin follow-up necessary after suspected spillage of trophoblast at the time of laparoscopic surgery for ectopic pregnancy显示文摘 | Bora SA Kirk E Daemen A | | 0，，04： | 1 |
| 20 | Evaluation of antioxidant and free- radical scavenging potential of Artemisia absinthium显示文摘 | Bora KS Sharma A | 2011 | Pharmaceutic al Biology2011，49，12： | 1 |
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