|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Short and long term prognosis in perinatal asphyxia: An update显示文摘Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to neonatal encephalopathy(NE) and resultant long-term damage. While the majority of infants who are exposed to perinatal hypoxia-ischaemia will recover quickly and go on to have a completely normal survival, a proportion will suffer from an evolving clinical encephalopathy termed hypoxic-ischaemic encephalopathy(HIE) or NE if the diagnosis is unclear. Resultant complications of HIE/NE are wide-ranging and may affect the motor, sensory, cognitive and behavioural outcome of the child. The advent of therapeutic hypothermia as a neuroprotective treatment for those with moderate and severe encephalopathy has improved prognosis. Outcome prediction in these infants has changed, but is more important than ever, as hypothermia is a time sensitive intervention, with a very narrow therapeutic window. To identify those who will benefit from current and emerging neuroprotective therapies we must be able to establish the severity of their injury soon after birth. Currently available indicators such as blood biochemistry, clinical examination and electrophysiology are limited. Emerging biological and physiological markers have the potential to improve our ability to select those infants who will benefit most from intervention. Biomarkers identified from work in proteomics, metabolomics and transcriptomics as well as physiological markers such as heart rate variability, EEG analysis and radiological imaging when combined with neuroprotective measures have the potential to improve outcome in HIE/NE. The aim of this review is to give an overview of the literature in regards to short and longterm outcome following perinatal asphyxia, and to discuss the prediction of this outcome in the early hours after birth when intervention is most crucial; looking at both currently available tools and introducing novel markers. | Caroline E Ahearne Geraldine B Boylan Deirdre M Murray | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 16 |
| 2 | Transfection of mammalian cells with plasmid DNA by scrape loading and sonication loading显示文摘 | Fechheimer M Boylan JF Parker S | | 0，，： | 1 |
| 3 | Construction of fused Lux AB gene by site directed mutagenesis显示文摘 | Boylan M O Pelletier J hepagnon S | 1989 | J Biolumin Chemilumin1989，4，： | 1 |
| 4 | Identification of a novel antigen on the apical surface of rat alveolar epithelial type Ⅱ and Clara cells 显示文摘 | Boylan G M Pryde J G Dobbs L G | 2001 | Am J Physiol Lung Cell Mol Physiol2001，280，6： | 1 |
| 5 | A Continuous striatal infusion of 6-OHDA prduces a terminal axolomy and delayed behavioval effects显示文摘 | Jones BE Boylan CB Fritsche M | 1996 | Brain Res1996，709，2： | 1 |
| 6 | Phytochromes: photosensory perception and signal transduction显示文摘 | Quail P H Boylan M T Parks B M | 1995 | Science1995，268，： | 1 |
| 7 | Fractures in cryopreserved elastic arteries显示文摘 | Pegg D E Wusteman M C Boylan S | 1997 | Cryobiology1997，34，： | 1 |
| 8 | Construction of fused Lux AB gene by site-directed mutagenesis显示文摘 | Boylan M O Pelletier J hepagnon S | 1989 | J Biolumin Chemilumin1989，4，： | 1 |
| 9 | Glucose dependent insulinotropic polypeptide modulates ad ipocyte lipolysis and reesterification 显示文摘 | Getty Kaushik L Song D H Boylan M O Corkey B E Wolfe M M | 2006 | Obesity (Silver Spring)2006，14，： | 1 |
| 10 | Phenobarbitone,neonatal seizures, and video-EEG显示文摘 | Boylan G B Rennie J M Pressler R | 2002 | Arch Dis Child2002，86，： | 1 |
| 11 | Oat phytochrome is biologically active in transgenie tomatoes显示文摘 | Boylan M T Quail P H | 1989 | The Plant Cell1989，1，8： | 1 |
| 12 | Phyto- chromes photosensory perception and signal trans- duction显示文摘 | QuailP H Boylan M T Parks B M | 1995 | Science1995，268，5211： | 1 |
| 13 | Non-expert use of the cerebral function monitor for neonatal seizure detection显示文摘 | Rennie J M Chorley G Boylan G B | 2004 | Arch Dis Child Fetal Neonatal Ed2004，89，1： | 1 |
| 14 | Phytochromes:photosensory perception and signal transduction显示文摘 | Quail P H Boylan Parks B M | 1995 | science1995，268，： | 1 |
| 15 | Deepening System Leadership:Teachers Leading from Below 显示文摘 | Boylan M | 2016 | Educational Management Adndnistration & Leadership2016，44，1： | 1 |
| 16 | Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A)显示文摘 | BOYLAN J M BRAUTIGAN D L | 2007 | Arch Biochem Biophys2007，461，2： | 1 |
| 17 | Cyclin-dependent kinase inhibitors: Useful targets in cell cycle regulation显示文摘 | Sielecki T M Boylan J F | 2000 | J Med Chem2000，43，1： | 1 |
| 18 | Models for Evaluating Airline Overbooking显示文摘 | Schubmehl M P Turner W M Boylan D M | 2002 | The Journal of Undergraduate Mathematics an its Applications2002，23，3： | 1 |
| 19 | Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy显示文摘 | Nadeem M Murray DM Boylan GB | | 0，，10： | 1 |
| 20 | Speciation of mercury in soil and sediment by selective solvent and acid ex- traction显示文摘 | Han Y Kingston H M Boylan H M | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员