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| 1 | Nasal nitric oxide and other diagnostic procedures in seasonal allergic rhinitis: elderly vs juvenile patients 显示文摘 | Bozek A Krajewska J Jarzab J | 2011 | Am J Otolaryngol2011，32，2： | 1 |
| 2 | Simulation of heat and moisture transfer in the greenhouse substrate due to a heating system by buried pipes 显示文摘 | Kurpaska S Slipek Z Bozek B | 2004 | Biosystems Engineering2004，90，1： | 1 |
| 3 | Glucagon-like-1 receptor agonists and sodium/glucose cotransporter-2 inhibitors combination—are we exploiting their full potential in a real life setting?显示文摘BACKGROUND The sodium/glucose cotransporter-2 inhibitors(SGLT-2i)and glucagon-like-1 receptor agonists(GLP-1RA)are antidiabetic agents effective both in hemoglobin A1c(HbA1c)reduction(with a low risk of hypoglycemia)and cardiovascular event prevention.In patients with type 2 diabetes,the add-on value of combination therapy of GLP-1RA and an SGLT-2i seems promising.AIM To investigate whether the efficacy of GLP-1RA and SGLT-2i combination observed in randomized controlled trials translates into therapeutic benefits in the Croatian population during routine clinical practice and follow-up.METHODS We included 200 type 2 diabetes patients with poor glycemic control and analyzed the effects of treatment intensification with(1)GLP-1RA on top of SGLT-2i,(2)SGLT-2i on top of GLP-1RA compared to(3)simultaneous addition of both agents.The primary study endpoint was the proportion of participants with HbA1c<7.0%and/or 5%bodyweight reduction.Secondary outcomes included changes in fasting plasma glucose(FPG),prandial plasma glucose,lowdensity lipoprotein cholesterol,estimated glomerular filtration rate(eGFR),and cardiovascular(CV)incidents assessment over a follow-up period of 12 mo.RESULTS The majority of patients were over 65-years-old,had diabetes duration for more than 10 years.The initial body mass index was 39.41±5.49 kg/m2 and HbA1c 8.32±1.26%.Around half of the patients in all three groups achieved target HbA1c below 7%.A more pronounced decrease in the HbA1c seen with simultaneous SGLT-2i and GLP-1RA therapy was a result of higher baseline HbA1c and not the effect of initiating combination therapy.The number of patients achieving FPG below 7.0 mmol/L was significantly higher in the SGLT-2i group(P=0.021),and 5%weight loss was dominantly achieved in the simultaneous therapy group(P=0.044).A composite outcome(reduction of HbA1c below 7%(53 mmol/mol)with 5%weight loss)was achieved in 32.3%of total patients included in the study.Only 18.2%of patients attained composite outcome defined as HbA1c below 7%(53 mmol/mol)with 5%weight loss and low-density lipoprotein cholesterol<2.5 mmol/L.There were no significant differences between treatment groups.No differences were observed regarding CV incidents or eGFR according to treatment group over a follow-up period.CONCLUSION Combination therapy with GLP-1RA and SGLT-2i is effective in terms of metabolic control,although it remains to be determined whether simultaneous or sequential intensification is better. | Maja Cigrovski Berkovic Ines Bilic-Curcic Tomislav Bozek Davorka Herman Mahecic Sanja KlobucarMajanovic Silvija Canecki-Varzic Jelena Andric Srecko Marusic Anna Mrzljak | 2020 | World Journal of Diabetes2020，11，11： | 1 |
| 4 | Kinetic study of transesterification of methyl acetate with n-butanol catalyzed by NKC-9显示文摘 | Bozek W E Gmehling J | 2006 | Industrial & Engineering Chemistry Research2006，45，2： | 1 |
| 5 | Macrophages, mieroglia, and astrocytes are rapidly activated after crush injury of the gold fish optic nerve: a light and electron microscopic analysis显示文摘 | Battisti WP Wang J Bozek K | 1995 | J Comp Neurol1995，354，2： | 1 |
| 6 | House dust mite sublingual immunotherapy: a double-blind, place- bo-controlled study in elderly patients with allergic rhi- nitis 显示文摘 | Bozek A Ignasiak B Filipowska B | 2013 | Clin Exp Allergy2013，43，2： | 1 |
| 7 | Epidemiology of IgE - dependent allergic diseasesin elderly patients in Poland 显示文摘 | Bozek A Jarzab J | 2013 | Am J Rhinol Allergy2013，27，5： | 1 |
| 8 | Scanning electron microscopic study of spermatozoa fi'om gossypol-treated rats 显示文摘 | Bozek SA Jensen DR | 1981 | Cell Tissue Res1981，219，： | 1 |
| 9 | Recent DIII-D divertor research显示文摘 | Allen S L Bozek AS Brooks NH | 1995 | Plasma Phys Control Fusion1995，191，： | 1 |
| 10 | Simulation of heat and moisture transfer in the greenhouse substrate due to a heating system by buried pipes 显示文摘 | KURPASKA S SLIPEK Z BOZEK B | 2005 | Biosystems Engineering2005，90，： | 1 |
| 11 | Intrauterine device-related-uterine per-foration显示文摘 | Murray JF Bozek JS 3rd | 2013 | J Am Osteopath Assoc2013，113，2： | 1 |
| 12 | Prevalence of Ig E-mediated allergy and evaluation of Th1/Th2 cytokine profiles in patients with severe bronchial asthma显示文摘 | Rogala B Bozek A Gluck J | 2015 | Postepy Dermatol Alergol2015，32，4： | 1 |
| 13 | The safety of spe- cific immunotherapy for patients allergic to house-dust mites and pollen in reaction to the development of neopla sia and autoimmune disease: a long-term, observational case-control study显示文摘 | Bozek A Kozlowska R Jarzab J | 2014 | Int Arch Allergy Immunol2014，163，4： | 1 |
| 14 | Detection of cer- ebral artery fenestrations by computed tomography angiography 显示文摘 | Bozek P Pilch Kowalczyk J Kluczewska E | 2012 | Neurol Neurochir Pol2012，46，3： | 1 |
| 15 | Montelukast as an add-on therapy to inhaled corticosteroids in the treatment of severe asthma in elderly patients 显示文摘 | Bozek A Warkocka-Szoltysek B Filipowska-Gronska A et a/ | 2012 | J Asthma2012，49，5： | 1 |
| 16 | Regulation of clock-con- trolled genes in mammals显示文摘 | Bozek K Relogio A Kielbasa SM | 2009 | PLoS One2009，4，： | 1 |
| 17 | Rooibos tea{Aspalathus linearis) partially prevents oxidative stress instreptozotocin-induced diabetic rats 显示文摘 | Ulicna 0 Vancova O Bozek P | 2006 | Physiol Res2006，55，2： | 1 |
| 18 | Imaging and assessment of glomus jugulare in MRI and CT techniques 显示文摘 | Bozek P Kluczewska E Lisowska G | 2011 | Otolaryngol Pol2011，65，3： | 1 |
| 19 | Emissions of selected pollutants while applying of specific additive enviroxTM显示文摘 | Frantisek Bozek Jiri Dvorak Jaromir Mares | 2011 | WSEAS Transactions on Environment and Development2011，7，8： | 1 |
| 20 | Arthmplasty in patients with congenital hip dysplasia-early evaluation of a treatment method显示文摘 | BOZEK M BIELECKI T NOWAK R | 2013 | Ortop Traumatol Rehabil2013，15，1： | 1 |
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