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| 1 | Male fertility following childhood cancer: current conceptsand future therapies显示文摘Prepubertal boys treated for cancer may exhibit impaired fertility in later life. A number of chemotherapeutic agents have been identified as being gonadotoxic, and certain treatment regimens, such as that used for Hodgkin's disease, are particularly associated with subsequent infertility. Radiotherapy may also cause gonadal damage, most notably following direct testicular irradiation or total body irradiation. Because of the varied nature of the cytotoxic insult, it can be difficult to predict the likelihood of infertility in later life. Currently it is not possible to detect gonadal damage early due to the lack of a sensitive marker of gonadal function in the prepubertal age group. Semen cryopreservation is currently the only method of preserving fertility in patients receiving gonadotoxic therapy. This is only applicable to postpubertal patients and can be problematic in the adolescent age group. At present there is no provision for the prepubertal boy, although there are a number of experimental methods currently being investigated. By harvesting testicular tissue prior to gonadotoxic therapy, restoration of fertility could be achieved following treatment, either by germ cell transplantation or by in vitro maturation of the germ cells harvested.Alternatively, rendering the testes quiescent during cytotoxic treatment may protect the germ cells from subsequent damage. In addition to the many scientific and technical issues to be overcome prior to clinical application of these techniques, a number of ethical and legal issues must also be addressed to ensure a safe and realistic prospect forfuture fertility in these patients. | Mark F. H. Brougham Christopher J. H.Kelnar Richard M.Sharpe W.Hamish B.Wallace | 2003 | Asian Journal of Andrology2003，5，4： | 2 |
| 2 | A segmentation analysis of resident attitudes to the social impact of tourism显示文摘 | Brougham J E Butler R W | 1981 | Annals of Tourism Research1981，8，4： | 1 |
| 3 | Water-soluble superparamagnetic magnetite nanopartieles with biocompatible coating for enhanced magnetic resonance imaging 显示文摘 | XIAO L LI J BROUGHAM DF | 2011 | ACS Nano2011，5，8： | 1 |
| 4 | Pastures and pasture management for high animal production in New Zealand显示文摘 | BROUGHAM R W COSGROVE G P | 1985 | Proc Inter Grassl Cong1985，15，： | 1 |
| 5 | MiR-379 regulates cyclin B1 expression and is decreased in breast cancer 显示文摘 | Khan S Brougham CL Ryan J | 2013 | PLoS One2013，8，68： | 1 |
| 6 | Epithelial to mesenchymal transition (EMT) and airway remodelling after hu- man lung transplantation 显示文摘 | Borthwick LA Parker SM Brougham KA | 2009 | Thorax2009，64，9： | 1 |
| 7 | The predictability of acetabular development after closed reduction for congenital dislocation of the hip显示文摘 | Brougham DI Broughton NS Cole WG | 1988 | J Bone Joint Surg Br1988，70，： | 1 |
| 8 | The effects of season and weather on the growth rate of a ryegrass and clover pasture显示文摘 | Brougham R W | 1959 | New Zealand Journal of Agricultural Research1959，，2： | 1 |
| 9 | Wettability effects in a sandstone reservoir and outcrop cores from NMR relaxation time distributions 显示文摘 | Guan H Brougham D Sorbie K S et d | 2002 | Journal of Petroleum Science and Engineering2002，34，： | 1 |
| 10 | Anti-Miillerian hor- mone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer:a prospective study 显示文摘 | Brougham MF Crofton PM Johnson EJ | 2012 | J Clin Endocrinol Metab2012，97，6： | 1 |
| 11 | Titanium(0) reagents: a selective and efficient deoxygenation of halogen containing heteroaromatic N-oxides显示文摘 | Brougham P Cooper S Cummerson D A | 1987 | Synthesis1987，，： | 1 |
| 12 | Multi-generational effects of four selected environmental oestrogens on Daphnia magna 显示文摘 | Brerman S J Brougham C A Roche J J | 2006 | Chemosphere2006，64，1： | 1 |
| 13 | Anti-mullerian hormone is a marker of gonadotoxicity in pre-and postpubertal girls treated for cancer:a prospective study显示文摘 | Brougham MF Crofton PM Johnson EJ | 2012 | J Clin Endocrinol Metab2012，97，6： | 1 |
| 14 | Ex vivo studies with iloperidone (HP 873), a potential atypical antipsychotie with dopamine D2/5-hydroxytryptamine2 receptor antagonist activity显示文摘 | Szczepanik AM Brougham LR Roehr JE | 1996 | J Pharmacol Exp Ther1996，278，2： | 1 |
| 15 | Stress, sex differences, and coping strategies among college students 显示文摘 | Brougham RR Zail CM Mendoza CM | 2009 | Current Psychology2009，28，： | 1 |
| 16 | The predictability of acetabular development after closed reduction for congenital dislocation of the hin显示文摘 | ?Brougham DI Broughton NS Cole WG | 1998 | J Bone Joint Surg(Br)1998，70，： | 1 |
| 17 | A Segmentation Analysis of Resident Attitudes to the Social Impact of Tourism 显示文摘 | Brougham J E R W Butler | 1981 | Annals of Tourism Research1981，8，4： | 1 |
| 18 | A Segmentation Analysis of Resident Attitudes to the Social Impact of Tourism 显示文摘 | Brougham J and Butler R | 1981 | Annals of Tourism Research1981，8，4： | 1 |
| 19 | Water-soluble superparamagnetic magnetite nanoparticles with biocompatible coating for enhanced magnetic resonance imaging显示文摘 | Xiao L Li J Brougham DF | 2011 | ACSnano2011，5，8： | 1 |
| 20 | A segmentation analysis of resident attitudes to the social impact of tourism 显示文摘 | Brougham J & Butler R | 1981 | Annals of Tourism Research1981，，8： | 1 |
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