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| 1 | Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas显示文摘AIM:To investigate endoscopic ultrasound(EUS) for predicting depth of mucosal invasion and to analyze outcomes following endoscopic and transduodenal resection.METHODS:Records of 111 patients seen at our institution from November 1999 to July 2011 with the postoperative pathological diagnosis of benign ampullary and duodenal adenomas were reviewed.Records of patients who underwent preoperative EUS for diagnostic purposes were identified.The accuracy of EUS in predicting the absence of muscular invasion was assessed by comparing EUS reports to the final surgical pathological results.In addition,the incidence of the post-operative complications over a period of 30 d and the subsequent long-term outcome(recurrence) over a period of 30 mo associated with endoscopic and transduodenal surgical resection was recorded,compared and analyzed.RESULTS:Among 111 patients with benign ampullary and duodenal adenomas,47 underwent preoperative EUS for 29 peri-ampullary lesions and 18 duodenal lesions.In addition,computed tomography was performed in 18 patients,endoscopic retrograde cholangio-pancreatography in 10 patients and esophagogastroduodenoscopy in 22 patients.There were 43 patients with sporadic adenomas and 4 patients with familial adenomatous polyposis(FAP)/other polyposis syndromes.In 38(81%,P < 0.05) patients,EUS reliably identified absence of submucosal and muscularis invasion.In 4 cases,EUS underestimated submucosal invasion that was proven by pathology.In the other 5 patients,EUS predicted muscularis invasion which could not be demonstrated in the resected specimen.EUS predicted tumor muscularis invasion with a specificity of 88% and negative predictive value of 90%(P < 0.05).Types of resection performed included endoscopic resection in 22 cases,partial duodenectomy in 9 cases,transduodenal ampullectomy with sphincteroplasty in 10 cases and pancreaticoduodenectomy in 6 cases.The main post-operative final pathological results included villous adenoma(n = 5),adenoma(n = 8),tubulovillous adenoma(n = 10),tubular adenoma(n = 20) and hyperplastic polyp(n = 2).Among the 47 patients who underwent resection,8(17%,5 of which corresponded to surgical resection) developed post-procedural complications which included retroperitoneal hematoma,intra-abdominal abscess,wound infection,delayed gastric emptying and prolonged ileus.After median followup of 20 mo there were 6 local recurrences(13%,median follow-up = 20 mo) 4 of which were in patients with FAP.CONCLUSION:EUS accurately predicts the depth of mucosal invasion in suspected benign ampullary and duodenal adenomas.These patients can safely undergo endoscopic or local resection. | Lilian C Azih Brett L Broussard Milind A Phadnis Martin J Heslin Mohamad A Eloubeidi Shayam Varadarajulu Juan Pablo Arnoletti | 2013 | World Journal of Gastroenterology2013，19，4： | 13 |
| 2 | Integrationdependent bacteriophage immunity provides insights into the evolution of genetic switches显示文摘 | Broussard G W Oldfield L M Hatfull G F | 2013 | Molecular Cell2013，49，2： | 1 |
| 3 | Serum and urine concentrations of trypsinogen-activation peptide as markers for acute pancreatitis in cats显示文摘 | ALLEN H S STEINER J BROUSSARD J | 2006 | Can J Vet Res2006，70，： | 1 |
| 4 | Cytokinehormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin like growth factor Ⅰ receptor in myoblasts显示文摘 | Broussard SR McCusker RH Novakofski JE | 2003 | Endocrinology2003，144，7： | 1 |
| 5 | Physiologically motivated image fusion for object detection using a pulse coupled neural network显示文摘 | BROUSSARD R ROGERS S | 1999 | IEEE Transactions on Neural Networks1999，10，3： | 1 |
| 6 | Physiologically motivated image fusion for object detection using a pulse coupled neural network 显示文摘 | Broussard R P Rogers S K Oxley M E | 1999 | IEEE Transaction on neural networks1999，10，3： | 1 |
| 7 | Wound dressings: selecting the most appropriate type 显示文摘 | Broussard KC Powers JG | 2013 | Am J Clin Dermatol2013，14，6： | 1 |
| 8 | Asymmetric focal adhesion disassembly in motile cells显示文摘 | Broussard J A Webb D J Kaverina I | 2008 | Curr Opin Cell Biol2008，20，： | 1 |
| 9 | Small size, big risk: preventing neonatal and pediatric medication errors 显示文摘 | Broussard L | 2010 | Nurs Womens Health2010，14，5： | 1 |
| 10 | Suppresses prolonged AKT activation and expression of E2F-1 and cyclin A in breast cancer cells 显示文摘 | Shen WH Jackson ST Broussard SR | 2004 | J Immunol2004，172，12： | 1 |
| 11 | Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping显示文摘 | Loh ED Broussard SR Liu Q | 2000 | Cytogenet Cell Genet2000，89，： | 1 |
| 12 | Tec kinases:modulators of lymphocyte signaling and development显示文摘 | Lewis CM Broussard C Czar MJ | 2001 | Curr Opin Immunol2001，13，3： | 1 |
| 13 | A quadratic weight selection algorithm显示文摘 | Broussard J R | 1982 | IEEE Trans on Automatic Control1982，27，4： | 1 |
| 14 | Synthe- ses, structures, and second-harmonic generating proper- ties in new quaternary tellurites: A2TeW3O12 (A = K, Rb, or Cs) 显示文摘 | GOODEY J OK K M BROUSSARD J | 2003 | J Solid State Chem2003，175，1： | 1 |
| 15 | Small size, big risk: preventing neonatal and pediatric medication errors显示文摘 | BROUSSARD L | 2010 | Nurs Womens Health2010，14，5： | 1 |
| 16 | Side population is enriched in tumorigenic, stem- like cancer cells, whereas ABCG2 + and ABCG22 cancer cells are similarly tumorigenic 显示文摘 | Patrawala L Calhoun T Schneider - Broussard R | 2005 | Cancer Res2005，65，14： | 1 |
| 17 | High envi- ronmental temperature and humidity decrease oocyte quality in Bos taurus but not in Bos indicus cows显示文摘 | Rocha A Randel R D Broussard J R | 1998 | Theriogenology1998，49，3： | 1 |
| 18 | Physiologically motivated image fusion for object detection using a pulse coupled neural network 显示文摘 | Broussard R P Rogers S K Oxley M E | 1999 | IEEE Transactions on Neural Networks1999，10，3： | 1 |
| 19 | TNM staging in colorectal cancer:T is for T cell and M is for memory 显示文摘 | Broussard EK Disis ML | 2011 | J Clin Oncol2011，29，6： | 1 |
| 20 | Simulation-based learning: How simulators help nurses improve clinical skills and preserve patient safety 显示文摘 | Broussard L | 2008 | Nurs Women''s Health2008，12，6： | 1 |
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