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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | 高热致胚胎发育毒性机理的研究——热休克蛋白合成显示文摘按Kimmel实验条件热暴露孕10天大鼠。暴露后2小时取胚胎用^(35)S—蛋氨酸标记,SDS—PAGE蛋白分析,可见70和90KilodaltonKD热休克蛋白合成增加。70KD HSP合成用Westernblot分析又进一步得到证实。离体培养胚胎热暴露后,用同样方法分析蛋白,证实70和90KD HSPs合成增加。结果与Kimmel骨骼畸形和胚胎体节融合发生率相符合。本结果为German提出的环境致畸机理假说提供了依据。 | 芦春林 C A Kimmel G L Kimmel D J Heredia B R Fisher N T Brown | 1993 | 北京医科大学学报1993，25，6： | 4 |
| 3 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 4 | Tolerance of normal tissue to therapeutic irradiation显示文摘 | Emami B Lyman J Brown A | | 0，，1： | 2 |
| 5 | Variation in fibre diameter profile characteristics between wool staple in Merino sheep 显示文摘 | Brown D J Crook B J Purvis I W | 2000 | Wool Technology and Sheep Breeding2000，，48： | 2 |
| 6 | Immobilisation of TiO2 powder for the treatment of polluted water显示文摘 | BYME J A EGGINS B R BROWN N M D | 1998 | Appl Catal B1998，17，： | 2 |
| 7 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 8 | Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes 显示文摘 | Cardosa M J Perera D Brown B A | 2003 | Emerg Infect Dis2003，9，4： | 1 |
| 9 | A general model for the structure and allometry of plant vascular systems 显示文摘 | West G B Brown J H Enquist B J | 1999 | Nature1999，400，： | 1 |
| 10 | Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998显示文摘 | Brown B A Oberste M S Alexander J P | 1999 | J Virol1999，73，： | 1 |
| 11 | Financing innovation and growth: Cash flows, external equity, and the 1990s R&D Boom显示文摘 | Brown J Fazzari S Petersen B | 2009 | Journal of Finance2009，，64： | 1 |
| 12 | The autonomic control of accommodation and implications for human myopia de- velopment : a review 显示文摘 | Chen J C Schmid K L Brown B | 2003 | Ophthalmic Physiol Opt2003，23，5： | 1 |
| 13 | Development of a global land cover characteristics database and IGBP DISCover from 1km AVHRR data 显示文摘 | Loveland T R Reed B C Brown J F | 2000 | International Journal of Remot Sensing2000，21，67： | 1 |
| 14 | Deleterious rhizosphere bacteria:An integrating perspectice显示文摘 | Nehl D B Allen S J Brown J F | 1996 | Applied Soil Ecology1996，5，： | 1 |
| 15 | Transient,turbulent,smooth pipe flow显示文摘 | VARDY A E BROWN J M B | 1995 | Journal of Hydraulic Research1995，33，4： | 1 |
| 16 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 17 | Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H) ones as inhibitors of the fatty acid transporter FATP4显示文摘 | Blackburn C Guan B Brown J | 2006 | Bioorg Med Chem Lett2006，16，13： | 1 |
| 18 | Delayed presentation of an enterocutaneous fistula after tension-free vaginal tape sling 显示文摘 | Westermann L B Brown A Long J B | 2011 | Female Pelvic Mcd Reconstr Surg2011，17，5： | 1 |
| 19 | Transient turbulent friction in smooth pipe flows显示文摘 | Vardy A E Brown J M B | 2003 | Journal of Sound and Vibration2003，259，5： | 1 |
| 20 | Cas RAF Age constraints on recycledcrustal and supracrustal sources of Archaean metasedimentary sequenc-es, Eastern Goldfields Province, Western Australia: evidence fromSHRIMP zircon dating显示文摘 | Krapez B Brown SJA Hand J | 2000 | Tectonophysics2000，322，： | 1 |
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