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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Analysis of feline calicivirus capsid protein genes:identification of varia ble antigenic determinant regions of the protein显示文摘 | Bruce S S Julia F R William L M | 1993 | J Gen Virol1993，74，： | 1 |
| 3 | Characteristics ofLow-income African-American and Caucasian Adults that Are Important in Self-management of Type 2 Diabetes显示文摘 | Cox R H Carpenter J P Bruce F A | 2004 | J Community Health2004，29，2： | 1 |
| 4 | Predicting fracture in cold upset forging by finite element methods显示文摘 | John L F Bruce R P | 1989 | J Material Shaping Technology1989，7，1： | 1 |
| 5 | Total Synthesis of ( + ) -Rocaglamide and Some Aryl Analogues显示文摘 | DOBLER M R BRUCE I CEDERBAUM F | 2001 | Tetrahedron Lett2001，42，： | 1 |
| 6 | SCR deactiva- tion in a full-scale confired utility boiler显示文摘 | Oshua R S Christopher J Z Bruce C F | 2008 | Fuel2008，87，： | 1 |
| 7 | Ma- ternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression 显示文摘 | Bruce K D Cagampang F R Argenton M | 2009 | Hepa- tolog2009，50，6： | 1 |
| 8 | Scanning probe microscopy显示文摘 | Richard J Colton^* David R Baselt Yves F Dufrkne John -Bruce D Greenand Gil U Lee | 1997 | Chemical Biology1997，1，： | 1 |
| 9 | phylogenetic utility of vegetative anatomy and fruit epidermal silica bodies in Carex section Phyllostachys (Cyperaceae)显示文摘 | Julian R S Bruce A F | 2001 | Canadian Journal of Botany2001，79，3： | 1 |
| 10 | Improved arc length orthogonality methods for nonlinear finite element analysis显示文摘 | Bruce W R Forde and Siegfried F Stiemer | 1987 | Computers & Structures1987，27，5： | 1 |
| 11 | Plasma-catalyst interactions in the treatment of volatile organic compounds and NOx with pulsed corona discharge and reticulated vitreous carbon Pt/Rh coated electrodes显示文摘 | Michael J K Wright C F Bruce R L | 2004 | Catalysis Today2004，89，1： | 1 |
| 12 | Maximal cardiac function in sedentary normal men and women: comparison of age-related changes显示文摘 | Bruce R A | 1982 | J Appl Physiol1982，53，4： | 1 |
| 13 | Giardiasis surveillance-United States, 1992-1997 显示文摘 | Bruce W F Michael J B Jacquelin M R | 2000 | Morbidity and Mortality Weekly Report CDC Surveillance Summary2000，49，1： | 1 |
| 14 | Monitoring organichlorines with semi-permeable membrane devices (SPMDs) and mussels (Mytilus edulis) in Corio Bay,Victoria,Australia显示文摘 | HARRY F P BRUCE J R LISA A J | 1995 | Marine Pollution Bulletin1995，30，8： | 1 |
| 15 | Maximal oxygen intake and nomographic assessment of functional aerobic impairement in cardiovascular disease 显示文摘 | BRUCE R A KUSUMI F HOSMER D | 1973 | Am Heart J1973，，85： | 1 |
| 16 | A Novel Route to Coenzyme Q10显示文摘 | Bruce H L Bulow G Lowe R F | 1996 | J Am Chem Soc1996，118，23： | 1 |
| 17 | Human Alveolar Macrophage Gene Responses to Mycobacterium tuberculosis Strains H37Ra and H37Rv显示文摘 | Silver Richard F Walrath Jessica Lee Hung Jacobson Bruce A Horton Heidi Bowman Michael R Nocka Karl Sypek Joseph P | 2009 | American Journal of Respiratory Cell and Molecular Biology2009，，： | 1 |
| 18 | Mitochondrial function and toxicity: role of B Vitamins on the onecarbon transfer pathways 显示文摘 | Depeint F Bruce W R Shangari N | 2006 | Chem Biol Interact2006，163，12： | 1 |
| 19 | Star coloring of graphs显示文摘 | GUILLAUME F ANDRI R BRUCE R | 2004 | Graph Theory2004，47，3： | 1 |
| 20 | Plasma-catalyst interactions in the treatment of volatile organic compounds and NOx with pulsed corona discharge and reticulated vitreous carbon Pt/Rh-coated electrodes显示文摘 | Michael J K Wright C F Bruce R L | 2004 | Catalysis Today2004，89，： | 1 |
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