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| 1 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 4 | mTOR:a protein kinase switching between life and death显示文摘 | Asnaghi L Bruno P Priulla M | 2004 | Pharmacol Res2004，50，6： | 1 |
| 5 | Overview of biacore systems and their applications显示文摘 | Jason-Moiler L Murphy M Bruno J | 2006 | Curr Protoe Protein Sei2006，19，： | 1 |
| 6 | Modeling diurnal and seasonal patterns of maize pollen emission in relation to meteo- rological factors显示文摘 | ALEXIS M Benjamin L Bruno A | 2011 | Agricultural and Forest Meteorology2011，151，1： | 1 |
| 7 | switching between life and death 显示文摘 | Asnaghi L Bruno P Priulla M o mTOR:a protein kinase | 2004 | Pharmacol Res2004，50，6： | 1 |
| 8 | A predictive model identifies patients most likely to have inadequate bowel preparation for colonoscopy 显示文摘 | Hassan C Fuccio L Bruno M | 2012 | Clin Gastroenterol Hepatol2012，10，： | 1 |
| 9 | In vitro and in vivo megakaryocyte differentiation of fresh and ex-vivo expanded cord blood cells: Rapid and transient megakaryocyte reconstitution 显示文摘 | Bruno S Gunetti M Gammaitoni L | 2003 | Haematologica2003，88，4： | 1 |
| 10 | Sex-stratifiedsocio-economie gradients in physical inactivity, obesity, and dia- betes:Evidence of short-term changes in Argentina 显示文摘 | BRUNO L FERNANDO D M DANIEL F | 2013 | lnt J Public Health2013，58，2： | 1 |
| 11 | Different growth factor requirements for the ex vivo amplification of transplantable human cord blood cells in a NOD/SCID mouse model显示文摘 | Bruno S Gammaitoni L Gunetti M | 2001 | J Biol Regul Homeost Agents2001，15，1： | 1 |
| 12 | Exchange Interactions and Temperature Dependence of Magnetization in Half- Metallic Heusler Alloys 显示文摘 | Sasloglu E Sandratskii L M Bruno P | 2005 | Phys Rev B2005，72，： | 1 |
| 13 | Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets 显示文摘 | Susanne M Florence S Bruno L | 2009 | Eur J Pharm Biopharm2009，72，1： | 1 |
| 14 | Maximisa-tion of heat transfer in a coil in tank PCM cold storage system显示文摘 | Castell A Belusko M Bruno F Cabeza L | 2011 | Applied Energy2011，，88： | 1 |
| 15 | Synthesis, characterisation and luminescence properties of MCM-41 impregnated with an Eu3+ β-diketonate complex 显示文摘 | BRUNO S M FERREIRA R A S CARLOS L D | 2008 | Micropor Mesopor Mater2008，113，13： | 1 |
| 16 | Videokeratograph (VKS) for monitoring corneal curvature during surgery显示文摘 | CARVALHO L A BRUNO O M TONISSI S | 2002 | Arq Bras Oftalmol2002，65，1： | 1 |
| 17 | Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project) 显示文摘 | Montagna MT Caggiano G Lovero G De Giglio O Cor- etti C Cuna T Iatta R Giglio M Dalfino L Bruno F Puntillo F | 2013 | Infection2013，41，3： | 1 |
| 18 | The effects of thrombopoietin on human hematopoietic stem cells显示文摘 | Murray L J Leuens K M Bruno E | 1998 | Blood1998，86，： | 1 |
| 19 | First-principles calculation of the intersublattice exchange interactions and Curie temperatures of the full Heusler alloys Ni2Mnx (X - Ga, In,Sn,Sb) 显示文摘 | Sasioglu E Sandratskii L M Bruno P | 2004 | Phys Rev B2004，70，2： | 1 |
| 20 | Using concept lattices to support service selection显示文摘 | Aversano L Bruno M Canfora G | 2006 | International Journal of Web Services Research2006，3，4： | 1 |
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