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| 1 | Key players in pancreatic cancer-stroma interaction: cancer-associated fibroblasts, endothelial and inflammatory cells显示文摘Pancreatic cancer(PC) is the most aggressive type of common cancers, and in 2014, nearly 40000 patients died from the disease in the United States. Pancreatic ductal adenocarcinoma, which accounts for the majority of PC cases, is characterized by an intense stromal desmoplastic reaction surrounding the cancer cells. Cancer-associated fibroblasts(CAFs) are the main effector cells in the desmoplastic reaction, and pancreatic stellate cells are the most important source of CAFs. However, other important components of the PC stroma are inflammatory cells and endothelial cells. The aim of this review is to describe the complex interplay between PC cells and the cellular and noncellular components of the tumour stroma. Published data have indicated that the desmoplastic stroma protects PC cells against chemotherapy and radiation therapy and that it might promote the proliferation and migration of PC cells. However, in animal studies, experimental depletion of the desmoplastic stroma and CAFs has led to more aggressive cancers. Hence, the precise role of the tumour stroma in PC remains to be elucidated. However, it is likely that a contextdependent therapeutic modification, rather than pure depletion, of the PC stroma holds potential for the development of new treatment strategies for PC patients. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2016 | World Journal of Gastroenterology2016，22，9： | 20 |
| 2 | 高产奶量的母猪有更高的采食量和体动员显示文摘选择能哺育更大窝产仔数的超高产母猪以提高产仔数,但是综合考虑这些现代母猪产奶量、采食量和体动员相互之间联系的研究还很有限。试验旨在研究什么样的母猪产奶量高、窝产仔数多,不同胎次有何影响,以及哺乳期生产性能对下一胎繁殖性能有何影响。选择565头1~4胎母猪,试验期从产前7 d至断奶。产后第2天每窝仔猪统一调整为14头。产前7 d、产后第2天和断奶时测定母猪体重和背膘厚度。产后第2天和断奶时称取仔猪窝重。计算变量之间的皮尔森相关系数,建立回归模型。母猪的平均日采食量(6.1±1.1)kg,仔猪每天窝增重(2.92±0.53)kg,每头母猪的平均断奶仔猪数(13.0±1.1)头。总的来讲,与2~4胎母猪相比,1胎母猪平均日采食量和产奶量更低,下一胎总产仔数也下降,这可能是因为初产母猪相比经产母猪会动用更多体储。仔猪每窝平均日增重与母猪的采食量、窝产仔数和体重损失呈正相关。1~4胎母猪整个哺乳期日采食量每提高1 kg,仔猪窝日增重提高220~440 g,母猪哺乳期体重下降6.6~13.9 kg。但是每天平均产奶量提高1 kg,第4胎母猪哺乳期体重损失减少4.3~21.0 kg。下一胎总产仔数与上一胎产仔数呈正相关。总之,高采食量和高体动员是高产奶量的先决条件。母猪可能已经非常接近他们身体饲料摄取的生理极限,因此,未来的研究应着眼于优化哺乳期超高产母猪的饲粮能量和营养浓度以及初产母猪和经产母猪之间的区别。 | Strathe A V Bruun T S Hansen C F 李元凤 | 2017 | 养猪2017，，4： | 8 |
| 3 | 定量分析加热后乳清蛋白与酪蛋白的结合显示文摘将复原脱脂乳在 70~ 90℃范围内加热 1 0~ 2 5min后 ,用超速离心分离出酪蛋白微粒 ,并用毛细管电泳法定量分析。结果显示 ,β-乳球蛋白更容易结合到酪蛋白微粒上。当加热条件为 70℃、1 0 min时就有相当多的 β-乳球蛋白发生了这种结合 ,这时酪蛋白微粒中没发现任何 α-乳清蛋白 ,只有当加热温度大于 75℃时才有少量 α-乳清蛋白与酪蛋白微粒结合。复原脱脂乳经 90℃、2 5min加热后几乎所有 β-乳球蛋白都已转入酪蛋白微粒部分 ,而只有近 50 %的α-乳清蛋白转入酪蛋白微粒。 | 周志伟 盛东生 许永红 Merete Faergem Jeanette Otte Karsten Bruun Qvist | 2000 | 食品工业科技2000，21，5： | 7 |
| 4 | 脱脂乳的不同热处理对其酸奶凝胶流变学性质的影响显示文摘研究了复原脱脂乳经不同加热处理后其酸奶凝胶形成过程中流变学特性的变化。复原脱脂乳经 70~ 90℃处理 10~ 2 5min ,用D 葡萄糖 δ 内酯酸化成胶。用流变学方法动态监测凝胶性能 ,并监测酸化过程和成胶时间。结果显示 ,不同条件下处理后的脱脂乳在酸化过程中 ,pH值并未改变 ,但凝胶储存模量 (G′)和损失模量 (G″)随受热程度的增加而增加 ,只是当加热温度为 90℃时反而随加热时间的延长而降低。在 85℃加热 2 5min或 90℃加热后 ,脱脂乳酸性凝胶的流变学曲线呈现出异常情况 ,这时G′和G″的增长出现两个迟缓期。 | 周志伟 许永红 Merete Faergemand Jeanette Otte Karsten Bruun Qvist | 2000 | 中国乳品工业2000，28，5： | 3 |
| 5 | Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations显示文摘AIM To determine whether it is possible to identify different immune phenotypic subpopulations of cancer-associated fibroblasts (CAFs) in pancreatic cancer (PC). METHODS We defined four different stromal compartments in surgical specimens with PC: The juxtatumoural, peripheral, lobular and septal stroma. Tissue microarrays were produced containing all pre-defined PC compartments, and the expression of 37 fibroblast (FB) and 8 extracellular matrix (ECM) markers was evaluated by immunohistochemistry, immunofluorescence (IF), double-IF, and/or in situ hybridization. The compartment-specific mean labelling score was determined for each marker using a four-tiered scoring system. DOG1 gene expression was examined byquantitative reverse transcription PCR (qPCR). RESULTS CD10, CD271, cytoglobin, DOG1, miR-21, nestin, and tenascin C exhibited significant differences in expression profiles between the juxtatumoural and peripheral compartments. The expression of CD10, cytoglobin, DOG1, nestin, and miR-21 was moderate/strong in juxtatumoural CAFs (j-CAFs) and barely perceptible/weak in peripheral CAFs (p-CAFs). The upregulation of DOG1 gene expression in PC compared to normal pancreas was verified by qPCR. Tenascin C expression was strong in the juxtatumoural ECM and barely perceptible/weak in the peripheral ECM. CD271 expression was barely perceptible in j-CAFs but moderate in the other compartments. Galectin-1 was stronger expressed in j-CAFs vs septal fibroblasts, PDGFRβ, tissue transglutaminase 2, and hyaluronic acid were stronger expressed in lobular fibroblasts vs p-CAFs, and plectin-1 was stronger expressed in j-CAFs vs l-FBs. The expression of the remaining 33 markers did not differ significantly when related to the quantity of CAFs/FBs or the amount of ECM in the respective compartments.CONCLUSION Different immune phenotypic CAF subpopulations can be identified in PC, using markers such as cytoglobin, CD271, and miR-21. Future studies should determine whether CAF subpopulations have different functional properties. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 6 | Experimental investigation of the energy separation in vortex tubes 显示文摘 | H H Bruun | 1969 | Journal mechanical engineering science1969，11，6： | 1 |
| 7 | Incidence,distribution,and spread of tetracycline resistance determinants and integron-associated antibiotic resistance genes among motile aeromonads from a fish farming environment显示文摘 | Schmidt A S Bruun M S Dalsgaard I | 2001 | Applied and Environmental Microbiology2001，67，12： | 1 |
| 8 | Gap jtmetion protein connexin 43 is heterogeneously expressed among glial cells in the adult rabbit retinal显示文摘 | Ehinfer B | 1999 | J Comp NruroL1999，407，3： | 1 |
| 9 | The role of socio-psychological and cultural-education motives in marketing international sport tourism: A Crosscultural Perspective显示文摘 | Funk D C Bruun T J | 2007 | Tourism Management2007，28，3： | 1 |
| 10 | The Bruun rule of erosion by sea level rise:a discussion on large scale two- and three-dimentional usages显示文摘 | BRUUN P | 1988 | Journal of Coastal Research1988，4，4： | 1 |
| 11 | Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity:implications for atherogenesis显示文摘 | Tanko LB Bruun JM Alexandersen P | 2004 | Circulation2004，110，15： | 1 |
| 12 | Site-Directed and Linker Insertion Mutagenesis of Herpes Simplex Virus Type 1 Glycoprotein H显示文摘 | Galdiero M Whiteley A Bruun B | 1997 | J Virol1997，71，3： | 1 |
| 13 | Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue(AT):implication of macrophages resident in the AT显示文摘 | BRUUN J M LIHN A S PEDERSEN S B | | 0，，： | 1 |
| 14 | Regulation of adiponectin by adipose tissue-derived cytokines:In vivo and in vitro investigations in humans显示文摘 | Lihn AS Verdich C | 2003 | Am J Physiol Endocrinol Metab2003，285，3： | 1 |
| 15 | Cytological studies in Primula显示文摘 | Bruun H G | 1932 | Symb BotUpsala1932，，1： | 1 |
| 16 | Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of maerophages resident in the AT显示文摘 | Bruun JM Lihn AS Pedersen SB | 2005 | J Clin Endoerinol Metab2005，90，4： | 1 |
| 17 | Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro显示文摘 | He G Pedersen SB Bruun JM | 2003 | Horm Metab Res2003，35，1： | 1 |
| 18 | In Situ Detection of Diamine Oxidase Activity Using Enhanced Chemiluminescence显示文摘 | BRUUN L HOUE G | 1996 | Analytical Biochemistry1996，233，： | 1 |
| 19 | Patterns of species richness in dry grassland patches in an agricultural landscape显示文摘 | BRUUN H H | 2000 | Ecography2000，23，： | 1 |
| 20 | Risperidone as a treatment for Tourette\'s syndrome显示文摘 | Bruun R D Budman C L | 1996 | J Clin Psychiatry1996，57，1： | 1 |
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