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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 4 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 5 | Colonoscopy versus fecal immuneoch-emical testing in colorectal cancer screening 显示文摘 | Quinlero E Castells A Bujanda L | 2012 | N Engl J Med2012，366，： | 1 |
| 6 | Krukenberg tumor secondary to gastric carcinoma in a women in her eighth month of pregnancy显示文摘 | Cosme A Ojeda E Bujanda L | 2001 | Gastroenterol Hepatol2001，24，1： | 1 |
| 7 | Malignant eolorectal polyps 显示文摘 | Bujanda L Cosme A Gil I | 2010 | WorldJ Gastroenterol2010，，25： | 1 |
| 8 | Malignant colorectal polyps 显示文摘 | Bujanda L Cosme A Gil I | 2010 | World J Gastroenterol2010，16，25： | 1 |
| 9 | Relevance of GSTM1, GSTF1, and GSTP1 gene polymor- phisms to gastric cancer susceptibility and phenotype 显示文摘 | GARCIA- GONZALEZ M A QUINTERO E BUJANDA L | 2012 | Muta- genesis2012，27，6： | 1 |
| 10 | Surface modification of polyamide fibers and films using atmospheric plasmas显示文摘 | PAPPAS D BUJANDA A DEMAREE J | 2006 | Surface and Coatings Technology2006，，201： | 1 |
| 11 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 12 | Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study显示文摘 | María Dolores Giráldez Juan José Lozano Georgina Ramírez Elizabeth Hijona Luis Bujanda Antoni Castells Meritxell Gironella | 2013 | Clinical Gastroenterology and Hepatology2013，，6： | 1 |
| 13 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 14 | MR1 and endoscopic ultrasonography in the staging of gastric cancer显示文摘 | Arocena MG Barturen A Bujanda L | | 0，，08： | 1 |
| 15 | Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study显示文摘 | María Dolores Giráldez Juan José Lozano Georgina Ramírez Elizabeth Hijona Luis Bujanda Antoni Castells Meritxell Gironella | 2013 | Clinical Gastroenterology and Hepatology2013，，6： | 1 |
| 16 | Congenital intrahepatic venous shunt as a cause of hepatic eneephalopathy 显示文摘 | Cosme Jimenez A Bujanda Ferndndez de Pierola L Poch Zapirain M | 1995 | Gastroenteol Hepatol1995，28，9： | 1 |
| 17 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 18 | Evaluation of alpha1 -antitrypsin and the levels of mRNA expression of matrix metallopro-teinase-7,urokinase type plasminogen activator receptor and COX-2for the diagnosis of colorectal cancer显示文摘 | Bujanda L Sarasqueta C Cosme A | 2013 | PLoS One2013，8，51： | 1 |
| 19 | Surface morphology and characteristics of hemocytes of Biomphalaria glabrata (Pulmonata:Planorbidae) from two geographic sources显示文摘 | Delgado V Barrios EE Bujanda A | | 0，，03： | 1 |
| 20 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
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