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| 1 | Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis显示文摘AIM: To examine whether visceral fat is associated with non-alcoholic steatohepatitis (NASH),to assess for parameters associated with visceral adiposity and to investigate for factors associated with fibrotic severity in NASH. METHODS: Thirty NASH and 30 control subjects underwent biochemical tests,anthropometric assessment,bioelectrical impedance,dual energy X-ray absorptiometry and abdominal fat study by CT scan. Liver biopsies were graded according to the Brunt criteria. RESULTS: NASH subjects had elevated blood pressure,body mass index,waist circumference and waist-to-hip ratio. A greater number of diabetes mellitus,impaired glucose tolerance test and HOMA-IR > 3.5 were found in NASH patients. HOMA-IR > 2.8 (OR 20.98,95% CI 3.22-136.62; P < 0.001) and visceral fat area > 158 cm2 (OR 18.55,95% CI 1.60-214.67; P = 0.019) were independent predictors for NASH. Advanced stage of NASH was found in 15 (50%) patients. HOMA-IR > 3.5 (OR 23.12,95% CI 2.00-266.23; P = 0.012) and grading of portal inflammation (OR 7.15,95% CI 1.63-31.20; P = 0.009) were determined as independent risk factors for advanced stage of NASH. CONCLUSION: Obesity (especially central obesity) and metabolic syndrome are common in Thai NASH. Insulin resistance and elevated visceral fat are risk factors for the presence of NASH. The advanced stage of thedisease is related to insulin resistance. | Abhasnee Sobhonslidsuk Sutipong Jongjirasiri Ammarin Thakkinstian Naruemon Wisedopas Pongamorn Bunnag Gobchai Puavilai | 2007 | World Journal of Gastroenterology2007，13，26： | 17 |
| 2 | Development of species-specific SCAR markers for identification of three medicinal species of Phyllanthus显示文摘Phyllanthus amarus Schum. & Thonn. has been widely used in traditional medicine in Thailand as an antipyretic, a diuretic, to treat liver diseases and viral infections. Two closely related species, P. debilis L. and P. urinaria Klein ex Willd., with different and less effective medicinal properties, are less commonly used. These three species are similar in morphology and often occur in overlapping populations in nature. The latter two species can easily be mistaken for P. amarus and collected for medicinal uses, which can lead to undesirable results. DNA fingerprints of these species were obtained using RAPD-PCR techniques. RAPD markers specific for each species were identified. Primers for highly specific sequence-characterized-amplified-regions (SCAR) were then designed from nucleotide sequences of specific RAPD markers. These primers efficiently amplified SCAR markers of 408, 501 and 319 bp unique to P. amarus, P. debilis and P. urinaria respectively. This method of plant identification was rapid and highly specific when tested against DNA of several closely related species and was able to amplify specific markers from mixed DNA samples. | Piyada THEERAKULPISUT Nantawan KANAWAPEE Duangkamol MAENSIRI Sumontip BUNNAG Pranom CHANTARANOTHAI | 2008 | 植物分类学报2008，46，4： | 4 |
| 3 | Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in Asian women with polycystic ovary syndrome显示文摘 | Weerakiet S Srisombut C Bunnag P | 2001 | Int J Gynaecol Obstet2001，75，2： | 1 |
| 4 | Artemether in the treatment of multiple drug resistant falciparum malaria显示文摘 | Bunnag D Karbwang J Harinasuta T | 1992 | Southeast Asian J Trop Med Pub Hlth1992，23，： | 1 |
| 5 | Effectiveness and cost analysis of community-based rehabilitation service in Bankok显示文摘 | Jitapunkul S Bunnag S Ebrahim S | 1998 | J Med Assoc Thai1998，81，8： | 1 |
| 6 | Clinical trial of artesunate and artemether on multi-drug resistant falciparum malaria in Thailand, a preliminary report显示文摘 | Bunnag D Viravan C Looareesuwan S | 1991 | Southeast Asian J Trop Med Pub Hlth1991，22，3： | 1 |
| 7 | Nasal endoscopic findings in patients with perennial allergic rhinitis 显示文摘 | Jareoncharsri P Thitadilok V Bunnag C | 1999 | Asian Pac J Allergy Immunol1999，17，： | 1 |
| 8 | Nasal endoscopic findings in patients with perennial allergic rhinitis显示文摘 | Jareoncharsri P Thitadilok V Bunnag C | 1999 | Asian Pac JAller Imrnunol1999，17，2： | 1 |
| 9 | Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008 显示文摘 | Pawankar R Bunnag C Khaltaev N | 2012 | The World Allergy Organization journal2012，5，3： | 1 |
| 10 | Prevalence of type2 diabetes mellitus and impaired glucose tolerance in Asian women with polycystic ovary syndrome显示文摘 | Weerakiet S Srisombut C Bunnag P | 2001 | Intem J Gynecol 0bstet2001，75，： | 1 |
| 11 | Plasma prostacyclin (PGI2) in dengue hemorrhagic fever显示文摘 | Preeyasombat C Bunnag P Sirinavin S | 1990 | Southeast Asian J Trop Med Public Health1990，21，3： | 1 |
| 12 | Allergic rhinitis and its impact on asthma update (ARIA 2008)--western and Asian-Pacific perspective显示文摘 | Pawankar R Bunnag C | | 0，，： | 1 |
| 13 | Prevalence of the metabolic syndrome in Asian women with polycystic ovary syndrome:Using the International Diabetes Federation criteria显示文摘 | Weerakiet S Bunnag P Phakdeekitcharoen B | 2007 | Gynecol Endocrinol2007，23，3： | 1 |
| 14 | Attenuation of endothelial dysfunction by exercise training in STZ-induced diabetic rets显示文摘 | Chakraphan D Sridulyakul P Thipakom B Bunnag S Huxley VH Patumraj S | 2005 | Clin Hemorheol Microeirc2005，32，3： | 1 |
| 15 | Genetic algorithm for constrained global optimization in continuous variables显示文摘 | Bunnag D Sun M | 2005 | Applied Mathematics and Computation2005，171，1： | 1 |
| 16 | Genetic algorithm for constrained global optimization in continuous variables显示文摘 | Bunnag D Sun M | 2005 | Applied Mathematics and Computation2005，171，1： | 1 |
| 17 | Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008 显示文摘 | Pawankar R Bunnag C Khal Taev N | 2012 | World Allergy Organ J2012，5，3： | 1 |
| 18 | Nasal endoscopic findings in patients with perennial allergic rhinitis显示文摘 | Jareoncharsri P Thitadilok V Bunnag C | 1999 | Asian Pae J Allergy Immunol1999，17，4： | 1 |
| 19 | Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of CAd staining 显示文摘 | Sis B Jhangri GS Bunnag S | 2009 | Am J Transplant2009，9，10： | 1 |
| 20 | Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease显示文摘 | Millan DS Bunnage ME Burrows JL | 2011 | Journal of Medicinal Chemistry2011，54，22： | 1 |
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