|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 高热致胚胎发育毒性机理的研究——热休克蛋白合成显示文摘按Kimmel实验条件热暴露孕10天大鼠。暴露后2小时取胚胎用^(35)S—蛋氨酸标记,SDS—PAGE蛋白分析,可见70和90KilodaltonKD热休克蛋白合成增加。70KD HSP合成用Westernblot分析又进一步得到证实。离体培养胚胎热暴露后,用同样方法分析蛋白,证实70和90KD HSPs合成增加。结果与Kimmel骨骼畸形和胚胎体节融合发生率相符合。本结果为German提出的环境致畸机理假说提供了依据。 | 芦春林 C A Kimmel G L Kimmel D J Heredia B R Fisher N T Brown | 1993 | 北京医科大学学报1993，25，6： | 4 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Culture of in vitro fertilized rabbit ova显示文摘 | Keefer C L Fayror-Hosken R A Brown L M | 1988 | Gamete Res1988，20，： | 2 |
| 4 | Rapid evolution of animal mitochondrial DNA 显示文摘 | BROWN W M GEORGE J R WILSON A C | 1979 | Proc Nat Acad Sci USA1979，76，19： | 2 |
| 5 | Polymorphic sites and the mechanism of evolution in human mitochondrial DNA 显示文摘 | Cano R L Brown W M Wilson A C | 1984 | Genetics1984，106，： | 2 |
| 6 | Hyperbaric oxygen in the treatment of elevated intracranial pressure after head injury, Pediatr显示文摘 | Brown J A PREUL M C TAHA A | 1988 | Neurosci1988，14，： | 1 |
| 7 | MIRA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium显示文摘 | Brown P K Dozois C M Nickerson C A | 2001 | Mol Microbiol2001，41，2： | 1 |
| 8 | Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxynitrite production and subsequent cell death 显示文摘 | McBride A G Borutaite V Brown G C | 1999 | Biochim Biophys Acta1999，1454，3： | 1 |
| 9 | CD4^+CD25^high regulatory cells in human peripheral blood 显示文摘 | Baecher-Allan C Brown J A Freeman G J | 2001 | J Immunol2001，167，3： | 1 |
| 10 | The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types显示文摘 | DICK C A BROWN D M DONALDSON K | 2003 | Inhal Toxicol2003，15，1： | 1 |
| 11 | Assessing the threat to life from dam failure显示文摘 | BROWN C A GRAHAM W J | 1988 | Water Resources Bulletin1988，24，6： | 1 |
| 12 | Heterogeneous oxidation of mercury in simulated post combustion conditions 显示文摘 | Norton G A Yang Hongqun Brown R C | 2003 | Fuel2003，82，2： | 1 |
| 13 | Toxic shock syndrome in a horse with Staphylococcus aureus pneumonia显示文摘 | HOLBROOK T C MUNDAY J S BROWN C A | 2003 | J Am Vet Med Assoc2003，222，5： | 1 |
| 14 | Breast cancer subtypes as defined by the estrogen receptor ( ER ), progesterone receptor ( PR ), and the human epidermal growth factor receptor 2 ( HER2 ) among women with invasive breast cancer in California, 1999-2004 显示文摘 | Parise C A Bauer K R Brown M M | 2009 | Breast J2009，15，6： | 1 |
| 15 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 16 | Specia- tion of arsenic using chelation solvent extraction mid high performance liquid chromatography 显示文摘 | CATHUM S J BROWN C E OBENAUF A | 2007 | Clean2007，35，1： | 1 |
| 17 | Absorption of a- mino acids from the intestine and their netflux across the mesenteric -and portal -drained viscera of lambs显示文摘 | MACRAE J C BRUCE L A BROWN D S | 1997 | J Anim Sci1997，75，12： | 1 |
| 18 | Do Venture Capitalists Add Value to Small Manufacturing Firms? An Empirical Analysis of Venture and Non- ventur e Capital - backed Initial Public of ferings 显示文摘 | Brau J C Brown R A Oster young J S | 2004 | Journal of Small Business Management2004，42，1： | 1 |
| 19 | Tree allometry and improved estimation of carbon stocks and balance in tropical forests显示文摘 | Chave J Andalo C Brown S Cairns M A Chambers J Q Eamus D Folster H Fromard F Higuchi N Kira T Lescure J P Nelson B W Ogawa H Puig H Riera B Yamakura T | | 0，，： | 1 |
| 20 | 'Silage' sycamore显示文摘 | McAlpine R Brown C Herrick A | 1966 | Forest farmer1966，26，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员