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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Structure properties of hydroxyapatite obtained by mechanosynthesis 显示文摘 | Silva C C Pinheiro A G Miranda M A R | 2003 | Solid State Sciences2003，5，： | 1 |
| 4 | Corrosion behaviour of new stainless steels reinforcing bars embedded in concrete 显示文摘 | Garcia-Alonso M C Escudero M L Miranda J M | 2007 | Cement and Concrete Research2007，37，10： | 1 |
| 5 | Information acquisition in group decision making 显示文摘 | Saunders C Miranda S | 1998 | Information & Management1998，34，1： | 1 |
| 6 | Can- diduria in hospital patients: a study prospective 显示文摘 | KOBAYASHI C C DE FERNANDES O F MIRANDA K C | 2004 | Mycopathologia2004，158，1： | 1 |
| 7 | Singular and non-singular approaches for predicting fatigue crack growth be- havior显示文摘 | Castro J T P Meggiolaro M A Miranda A C O | 2005 | International Journal of Fatigue2005，27，： | 1 |
| 8 | Antibiotic resistant bacteria in fish from the Concepcion Bay,Chile显示文摘 | C D Miranda R Zemelman | 2001 | Marine Pollution i3ul- letin2001，42，11： | 1 |
| 9 | Xanthohu- mol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells 显示文摘 | Colgate E C Miranda C L Stecens J F | 2007 | Cancer letters2007，246，1： | 1 |
| 10 | Phenylmercury degradation by heterogeneous photocatalysis assisted by UV-A light显示文摘 | Miranda C Yanez J Contreras D | 2013 | Journal of Environmental Science and Health Part A2013，48，13： | 1 |
| 11 | Vasopressin and the regulation of aquaporin-2 显示文摘 | Wilson J L Miranda C A Knepper M A | 2013 | Clin Exp Nephrol2013，17，： | 1 |
| 12 | Sphingosine 1 phosphate is a key regulator of proliferation and differentia tion in retina photoreceptors显示文摘 | Miranda G E Abrahan C E Politi L E | 2009 | Invest OphthaLmoL Vis Sci2009，50，9： | 1 |
| 13 | Phenylisothiocyanate and dansyl chloride precolumn derivatizations for the high performance liquid chromatography analysis of the antitumoral agent ES-285 in dog plasma显示文摘 | MARASCHIELLO C MIRANDA E MILLAN E | 2003 | Journal of Chromatography B2003，791，： | 1 |
| 14 | Presence of qacEΔ1 gene and susceptibility to a hospital biocide in clinical isolates of Pseudomonas aeruginosa resistant to antibiotics显示文摘 | Romao C Miranda C A Silva J | 2011 | Curr Microbiol2011，63，1： | 1 |
| 15 | Diversity o{ tetracycline resistance genes in bacteria from Chilean salmon farms 显示文摘 | Miranda C D Kehrenberg C Ulep C | 2003 | Antimicrobial Agents and Chemo therapy2003，47，88： | 1 |
| 16 | Canine parvovirus 2c infection in a cat with severe clinical disease显示文摘 | Miranda C Parrish C R Thompson G | 2014 | J Vet Diagn Invest2014，26，3： | 1 |
| 17 | Distinguishing severe asthma phenotypes : role of age at onset and eosinophilic inflammation 显示文摘 | Miranda C Busacker A Balzar S | 2004 | J Allergy Clin Immunol2004，113，1： | 1 |
| 18 | Photochemistry of metal nitrosyl complexes,delivery of nitric oxide to biological targets显示文摘 | Ford P C Bourassa J Miranda K | 1998 | Coord Chem Rev1998，171，： | 1 |
| 19 | Structural properties of hydroxyapalile obtained by mechanosynlhesis显示文摘 | Silver C C Pinheiro A G Miranda M A R | 2003 | Solid Stale Sciences2003，5，4： | 1 |
| 20 | Characterization of sugarcane and coconut fibers by thermal analysis and FTIR显示文摘 | Mothe C G De Miranda | 2009 | Journal of Thermal Analysis and Calorimetry2009，97，2： | 1 |
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