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| 1 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 2 | Augmentation of a loosened sacral pedicle screw with percutaneous polymethylmethacrylate injection 显示文摘 | Yilmaz C Atalay B Caner H | 2006 | J Spinal Disord Tech2006，5，： | 1 |
| 3 | Putting chirality to work: the strat- egy of chiral switches显示文摘 | Agranat I Caner H Caldwell J | 2002 | Nat Rev Drug Disc2002，1，10： | 1 |
| 4 | Meningiomas of the lateral ventricle: report on six cases 显示文摘 | Caner H Acikgoz B Ozgen T | 1992 | Neurosurg Rev1992，15，： | 1 |
| 5 | Efficient embedded neural-network-based license plate recognition system 显示文摘 | Caner H Gecim H S Alkar A Z | 2008 | IEEE Transactions on Vehicular Technology2008，57，5： | 1 |
| 6 | Meningiomas of the lateral ventricle:report on six cases显示文摘 | Caner H Acikgoz B Ozgen T | 2002 | Neurosurg Rev2002，15，5： | 1 |
| 7 | Meningiomas of the Cateral Ventricle:report on six cases显示文摘 | Caner H Acikgoz B Ozgen T | 1992 | Neurosurg Rev1992，152，： | 1 |
| 8 | Meningiomas of the lateral ventricle: report on six cases显示文摘 | Caner H Acikgoz B Ozgen T | 1992 | Neurosurg Rev1992，15，： | 1 |
| 9 | Ogilvie's syndrome as a rare complication of lumbar disc surgery显示文摘 | Caner H Bavbek M Albayrak A | 2000 | Can J Neurol Sci2000，27，7： | 1 |
| 10 | An unusual dumbbell form of cavernous hemangioma of the cervical spine 显示文摘 | Bavbek M Yurt A Caner H | 1997 | Kobe J Med Sci1997，43，2： | 1 |
| 11 | Meningiomas of the lateral ventricle: report on six cases 显示文摘 | Caner H Acikgoz B Ozgen T | 1992 | Neurosurg Rev1992，15，4： | 1 |
| 12 | Congenital cardiac mal formations in neonates with apparently isolated gastrointesti nalmalformations显示文摘 | Olgun H Karacan M Caner I | 2009 | Pediatr Int2009，51，2： | 1 |
| 13 | The effect ofmexiletine on the level of lipid peroxidation and apoptosis ofendothelium following experimental subarachnoidhemorrhage显示文摘 | SEN O CANER H AYDIN M V | 2006 | Neurol Res2006，28，8： | 1 |
| 14 | The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage 显示文摘 | Sen O Caner H Aydin MV | 2006 | Neurol Res2006，28，8： | 1 |
| 15 | Efficient embedded neural-network-based license plate recognition system显示文摘 | Caner Hakan Selcuk Gecim H Ziya Alkar Ali | 2008 | IEEE Transactions on Vehicular Technology2008，57，5： | 1 |
| 16 | Presence of iodine in rocks,soil and waters and its relation to goitre显示文摘 | Caner H | 1929 | Landwirtschaftliches Jahrbueh1929，77，： | 1 |
| 17 | Augmentation of loosened sacral pedicle SCre with percutaneous polymethylmethacrylate injection 显示文摘 | Yilmaz C Atalay B Caner H et a l | 2006 | J Spinal Disord Tech2006，19，5： | 1 |
| 18 | Ogilvie's syndrome as a rare complication of lumbar disc surgery显示文摘 | Caner H Bavbek M AJbayrak A | | Canadian Journal of Neurological Sciences0，，： | 1 |
| 19 | Meningiomas of the lateral ventricle(Repot on six cases)显示文摘 | Caner H Acikgoz B Ozgen T | 1992 | Neurosurg Rev1992，15，4： | 1 |
| 20 | Efficient embedded neural -network-based license plate recognition system 显示文摘 | CANER H GECIMH S ALKAR A Z | 2008 | IEEE Transaction on Vehicular Technology2008，57，5： | 1 |
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