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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan显示文摘AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica. | Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 3 | Azithromycin for the secondary prevention of coronary heart disease events:The WIZARD study:a randomized controlled trial显示文摘 | O'Con nor CM Dun ne M W Pfeffer M A | | 0，，： | 1 |
| 4 | Production of bacteriocin-like metabolites by lactic acid cultures isolated from sucuk samples显示文摘 | Con A H Gokalp H Y | 2000 | Meat Science2000，55，1： | 1 |
| 5 | The site of action of pantoprazole in the gastric H+, K+ - ATP ase显示文摘 | Shin JM Besan con M Simon A | 1993 | Biochim Biophys Acta1993，1148，： | 1 |
| 6 | The role of monocyte chemoattractant protein MCP1/CCL2 in neuro inflammatory diseases 显示文摘 | Con ductier G Blon deau N Guyon A | 2010 | J Neuroimmunol2010，224，12： | 1 |
| 7 | Measurement of trihalomethanes in potable and recreational waters using solid phase micro extraction with gas chromatographymass spectrometry显示文摘 | STACK M A FITZGERALD G O' CON NELL S | 2000 | Chemosphere2000，41，11： | 1 |
| 8 | Ectopic expression of mouse Sry interferes with Wnt/beta-catenin signaling in mouse embryonal carcinoma cell lines显示文摘 | TAMASHIRO D A ALAR CON V B MARIKAWA Y | 2008 | Biochim Biophys Acta2008，1780，12： | 1 |
| 9 | Growth of hydrocarbon-utilizing isolated in chemical ly defined media显示文摘 | Haiim A EL-Sayed M M Mahmond W M Davis E M Con ghlin R W | 1996 | International Biodeterioration & Biodegra dation1996，37，12： | 1 |
| 10 | Effectiveness of or',d moxifloxacin in standard first-line therapy in community acquired pneumonia 显示文摘 | Tortes A Muir JF Con'is P er al | 2003 | Rur- Respir J2003，21，1： | 1 |
| 11 | Pathogenesis, clinical find- ings and management of acute and chronic gout 显示文摘 | Con'ado A D' Onofrio F Santoro N | 2006 | Minerva Med2006，97，6： | 1 |
| 12 | Ventilatory and respiratory muscle response to hypercapnia in patients with paraplegia显示文摘 | Gorini M Con'ado A Aito S | 2000 | Am J Respir Crit Care Med2000，162，： | 1 |
| 13 | Optimal Linear PI Fuzzy Controller Design of a Heat Exchanger显示文摘 | Maidi A Diaf M Con'iou J P | 2008 | Chemical Engi2 Neering and Processing2008，47，5： | 1 |
| 14 | The Synergism hypothesis :on the concept of synergy and its role in the evolution of complex systems显示文摘 | Conning Peter A | 1998 | Journal of Social and Evolutionary Systems1998，21，2： | 1 |
| 15 | Thermal resistance of Alicyclobacillus acidoterrestris spores in different heating media 显示文摘 | Ceviz G Tulek Y Con A H | 2009 | International Journal of Food Science and Technology2009，44，9： | 1 |
| 16 | Ingtracking of cosmetic formulations in the skin: A confocal Raman microscopy investigation 显示文摘 | Forster M Bolzinger M A Ach D Montagnac G Brian- con S | 2011 | Pharm Res2011，28，： | 1 |
| 17 | Functional analysis of AtHKT1 in Arabidopsis shows that Na+ recirculation by the phloem is crucial for salt tolerance显示文摘 | Berthomieu P Conéjéro G Nublat A | 2003 | The EMBO Journal2003，22，： | 1 |
| 18 | A Survey of methods available for the numerical optimization of continuous dynamic systems 显示文摘 | Con'aay B A | 2012 | Optimization Theory and Applications2012，152，2： | 1 |
| 19 | Stabilization mechanisms of soil organic matter: implications for C saturation of soils 显示文摘 | Six J Con ant R T Paul E A | 2002 | Plant and Soil2002，241，： | 1 |
| 20 | Influence of growth conditions on the nisin production of bioengineered Lactococcus lactis strains显示文摘 | SIMSEK (O) CON A AKKO N | 2009 | Journal of Industrial Microbiology & Biotechnology2009，36，4： | 1 |
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