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| 1 | Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis显示文摘Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic epithelial.UC-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal cancer.In fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite instability.Hypermethylation of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory carcinogenesis.Moreover,p53 is frequently mutated in the early stages of UC-associated cancer.Aneuploidy is an independentrisk factor for forthcoming carcinogenesis in UC.Epithelial cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis. | Marco Scarpa Ignazio Castagliuolo Carlo Castoro Anna Pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 2 | Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides显示文摘Engineered scaffolds for bone tissue regeneration are designed to promote cell adhesion,growth,proliferation and differentiation.Recently,covalent and selective functionalization of glass and titanium surfaces with an adhesive peptide(HVP)mapped on[351e359]sequence of human Vitronectin allowed to selectively increase osteoblast attachment and adhesion strength in in vitro assays,and to promote osseointegration in in vivo studies.For the first time to our knowledge,in this study we investigated the resistance of adhesion sequences to proteolytic digestion:HVP was completely cleaved after 5 h.In order to overcome the enzymatic degradation of the native peptide under physiological conditions we synthetized three analogues of HVP sequence.A retro-inverted peptide D-2HVP,composed of D amino acids,was completely stable in serum-containing medium.In addition,glass surfaces functionalized with D-2HVP increased human osteoblast adhesion as compared to the native peptide and maintained deposition of calcium.Interestingly,D-2HVP increased expression of IBSP,VTN and SPP1 genes as compared to HVP functionalized surfaces.Total internal reflection fluorescence microscope analysis showed cells with numerous filopodia spread on D-2HVP-functionalized surfaces.Therefore,the D-2HVP sequence is proposed as new osteoblast adhesive peptide with increased bioactivity and high proteolytic resistance. | Annj Zamuner Paola Brun Michele Scorzeto Giuseppe Sica Ignazio Castagliuolo Monica Dettin | 2017 | Bioactive Materials2017，2，3： | 3 |
| 3 | Beneficial effect of auto-aggregating Lactobacillus crispatus on experimental induced colitis in mice显示文摘 | Castagliuolo I Galeazzi F Ferrari S | 2005 | FEMS Immunology and Medical Microbiology2005，43，： | 1 |
| 4 | Increased intestinal permeability in obese mice:new evidence in the pathogenesis of nonalcoholic steatohepatitis显示文摘 | Brun P Castagliuolo l Di L V | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，2： | 1 |
| 5 | Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins显示文摘 | Pothoulakis C Castagliuolo I Lamont JT | 1998 | News Physioll Sci1998，13，： | 1 |
| 6 | Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and Herpes Simplex Vires thymidine kinase显示文摘 | Barzon L Bonaguro R Castagliuolo I | 2003 | Eur J Endoefinol2003，148，1： | 1 |
| 7 | Saccharomy- ces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum显示文摘 | Castagliuolo I LaMont JT Nikulasson ST | 1996 | Infect Immun1996，64，12： | 1 |
| 8 | Neurokinin-1 (NK-1) receptor is required in clostridium difficileinduced enteritis显示文摘 | RIEGLER M PASHA A | 1998 | J Clin Invest1998，101，8： | 1 |
| 9 | 显示文摘 | Pothoulakis C Castagliuolo I LaMont JT | 1998 | News Physiol Sci1998，13，： | 1 |
| 10 | Mucosal genetic immunization against four adhesions protects against staphylococcus aurous induced mastitis in mice 显示文摘 | Castagliuolo I Piccinini R Beggiao E | 2006 | Vaccine2006，24，20： | 1 |
| 11 | Increased intestinal permeability in obese mice: new evidences in the pathogenesis of nonalcoholic steatohepatitis 显示文摘 | BRUN P CASTAGLIUOLO 1 DI LEO V | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，2： | 1 |
| 12 | Beneficial Effect of Auto-aggregating Lactobacillus Crispatus on Experimentally Induced Colitis in Mice 显示文摘 | CASTAGLIUOLO I GALEAZZI F FERRARI S | 2005 | FEMS Immunology and Medical Microbiology2005，43，2： | 1 |
| 13 | Acute stress causes mucin release from rat colon: Role of corticotropin releasing factor and mast cells显示文摘 | Castagliuolo I Lamont J T Qiu B | 1996 | American Journal of Physiology1996，271，5： | 1 |
| 14 | Increased intes- tinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis 显示文摘 | Brun P Castagliuolo I Di Leo V | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，2： | 1 |
| 15 | Increased intestinal permeability in obese mice : new evidence in the pathogensis of nonalcoholic steatohepatitis 显示文摘 | BRUN P CASTAGLIUOLO I LEO V D | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，： | 1 |
| 16 | Acute stress caus- esmucin release from rat colon : role of corticotro pin releasing fac- torand mast cells显示文摘 | CASTAGLIUOLO L LAMONT JT QIU B | 1996 | Am J Physiol1996，271，： | 1 |
| 17 | Systemic efficacy of combined suicide/cytokine gene therapy in a murine model of hepatocellular carcinoma显示文摘 | Stefani AL Barzon L Castagliuolo I | 2005 | Hepatol2005，42，5： | 1 |
| 18 | Increased intesti-nal permeability in obese mice:new evidence in the patho-genesis of nonalcoholic steatohepatitis显示文摘 | Brun P Castagliuolo L Di Leo V | 2007 | Am J PhysiolGastrointest Liver Physiol2007，292，2： | 1 |
| 19 | Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis 显示文摘 | Brun P Castagliuolo I Di Leo V | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，2： | 1 |
| 20 | Mucosal genetic immunization against four adhesins protects against Staphylococcus aureus-induced mastitis in mice显示文摘 | Ignazio Castagliuolo Renata Piccinini Elisa Beggiao | 2006 | Vaccine2006，24，： | 1 |
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