|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 2 | An experimental study of secondary oil migration显示文摘 | Catalan L Xiaowen F Chatzis I | 1992 | AAPG Bulletin1992，76，5： | 1 |
| 3 | Evidence for a combined genetic effect of the 5-HT1A receptor and serotonin transporter genes in the clinical outcome of major depressive patients treated with citalopram 显示文摘 | Arias B Catalan R Gasto C | 2005 | J Psychopharmacol2005，19，2： | 1 |
| 4 | On the effects of non-linear elements in the reliability-based optimal design of stochastic dynamical systems 显示文摘 | Hector A Jesen Michel A Catalan | 2007 | Non-linear Mechanics2007，42，： | 1 |
| 5 | Triterpenes and other constituents of Nassauvia axillaris显示文摘 | CLAUDIA KOTOWICZ CESAR A N CATALAN CLAIRE L GRIFFIN | 2005 | Biochemical Systematics and Ecology2005，33，： | 1 |
| 6 | Acute hemorrhagic leukoencephalitis with atypical features显示文摘 | Catalan M Naccarato M Grandi FC | 2009 | Neurol Sci2009，30，1： | 1 |
| 7 | An experimental study of secondary oil migration 显示文摘 | Catalan L Xiaowen F Chatzis I | 1992 | AAPG Bulletin1992，76，： | 1 |
| 8 | Pallial oviduct of Pomacea ccmaliculata (Gastropoda): uhrastructural studies of the parenchymal cellular types involved in the metabolism of perivitellins显示文摘 | Catalan M Dreon M S Heras H | 2006 | Cell Tissue Research2006，324，： | 1 |
| 9 | Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes 显示文摘 | Rodriguez A Gomez-Ambrosi J Catalan V | 2009 | Int J Obes ( Lond)2009，33，5： | 1 |
| 10 | Study of graft copolymerization on secondary cellulosic fiber with acrylonitrile 显示文摘 | Catalan R Neira A Rivas B | 2002 | J Appl Polym Sci2002，90，1： | 1 |
| 11 | Spectrothermodynamic relationship of cationic vs anionic species derived from protonation vs deprotonation of purrolo-aza-aromatic bases in homoloqous series显示文摘 | CATALAN J | 2001 | J Am Chem Soc2001，123，11： | 1 |
| 12 | Manual assisted cognitive behavior therapy (MACT) : A randomized controlled trial of a brief intervention with bibliotherapy in the treatment of recurrent detiherate self- harm 显示文摘 | Evans K Tyrer P Catalan J Schmidt U Davidson K Dent J | 1999 | Psychological Medicine1999，29，： | 1 |
| 13 | Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction显示文摘 | Devor M Wall PD Catalan N | 1992 | Pain1992，48，2： | 1 |
| 14 | Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus,but is reduced after relevant reductions in body fat following gastric bypass显示文摘 | Gomez-Ambrosi J Rodriguez A Catalan V | 2008 | Clin Endocrinol2008，69，2： | 1 |
| 15 | 'Acylat-ed and desacyl ghrelin stimulate lipid accumulation in hu- man visceral adipocytes' 显示文摘 | Rodriguez A Gomez-Ambrosi J Catalan V | 2009 | International J Obesity2009，33，5： | 1 |
| 16 | Spectrophoto- metric deter - mination of chromium with diphenylcarbazide in the presence of vanadium, molybdenum, andiron after separation by solid -phase extraction显示文摘 | Llobat - Estelles M Mauri - Aueejo A R Lopez- Catalan M D | 2001 | Fresenius J Anal Chem2001，371，3： | 1 |
| 17 | Associations between empirical antimicrobial therapy at the hospital and mortality in patients with severe community-acquired pneumonia显示文摘 | Catalan M Diaz E | 2002 | Intensive Care Med2002，28，： | 1 |
| 18 | Dielectric and electromechanical properties of Pb( Mgl/3, Nb2/3 )03 - PbTiO3 thin films grown by pulsed laser deposition显示文摘 | DONNELLY N J CATALAN G MORROS C | 2003 | J Appl Phys2003，93，： | 1 |
| 19 | The functional neuroanatomy of simple and complex sequential finger movements: a PET study显示文摘 | Catalan MJ Honda M Weeks RA | 1998 | Brain1998，121，2： | 1 |
| 20 | Modulation of protein kinase C is isoforms by PAF in cerebral cortex显示文摘 | Colcerrada MC Rerez MJ Catalan RE | 1999 | Prostaglandins Lipid Mediat Ors1999，58，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员