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| 1 | Constipation,deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alphasynucleinopathy显示文摘Background:Gastrointestinal dysfunction can affect Parkinson’s disease(PD)patients long before the onset of motor symptoms.However,little is known about the relationship between gastrointestinal abnormalities and the development of PD.Contrary to other animal models,the human A53T alpha-synuclein(αS)transgenic mice,Line G2–3,developsαS-driven neurological and motor impairments after 9 months of age,displaying a long presymptomatic phase free of central nervous system(CNS)dysfunction.Methods:To determine whether this line can be suitable to study constipation as it occurs in prodromal PD,gastrointestinal functionality was assessed in young mice through a multidisciplinary approach,based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations.Results:We found that the A53TαS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities andαS pathology in the CNS by at least 6 months.YoungαS mice show a drastic delay in food transit along the gastrointestinal tract,of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months.Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted,suggesting a deficit in the intestinal peristalsis.In agreement with this,electrically evoked contractions of the colon,but not of the ileum,showed a reduced motor response in both longitudinal and circular muscle layers inαS mice already at 3 months of age,that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system.Interestingly,the presence of insoluble and aggregatedαS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months oldαS mice,but not in the small intestine,and exacerbated with age,mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data.Conclusions:Gastrointestinal dysfunction in A53TαS mice represents an early sign ofαS-driven pathology without concomitant CNS involvement.We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and haltαS pathology from reaching the brain. | Lucia Rota Carolina Pellegrini Laura Benvenuti Luca Antonioli Matteo Fornai Corrado Blandizzi Antonino Cattaneo Emanuela Colla | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 2 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 3 | Development of an HPLC–UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients显示文摘A new method using high-performance liquid chromatography coupled with ultra violet detection(HPLC–UV)was developed and validated for the simultaneous quantification of atazanavir,dolutegravir,darunavir,efavirenz,etravirine lopinavir,raltegravir,rilpivirine and tipranavir in human plasma.For the first time we reported here the development and validation of an HPLC–UV assay to quantify the frequently administered 9antiretroviral compounds including dolutegravir and rilpivirine.A simple solid phase extraction procedure was applied to 500 μL aliquots of plasma.The chromatographic separation of the drugs and internal standard(quinoxaline) was achieved with a gradient of acetonitrile and sodium acetate buffer on a C_(18) reverse-phase analytical column with a 25 min analytical run time.Calibration curves were optimised according to the therapeutic range of drug concentrations in patients,and the coefficient of determination(r^2) was higher than0.99 for all analytes.Mean intraday and interday precisions(RSD) for all compounds were less than 15.0%,and the mean accuracy(% deviation from nominal concentration) was also found to be less than 15.0%.Extraction recovery range was between 80% and 120% for all drugs analysed.The solid phase extraction and HPLC–UV method enable a specific,sensitive,and reliable simultaneous determination of nine antiretroviral agents in plasma.Good extraction efficiency and low limit of HPLC–UV quantification make this method suitable for use in clinical trials and therapeutic drug monitoring. | Nitin Charbe Sara Baldelli Valeria Cozzi Simone Castoldi Dario Cattaneo Emilio Clementi | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 4 |
| 4 | Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate显示文摘 | Laurent Bonello Udaya S. Tantry Rossella Marcucci Ruediger Blindt Dominick J. Angiolillo Richard Becker Deepak L. Bhatt Marco Cattaneo Jean Philippe Collet Thomas Cuisset Christian Gachet Gilles Montalescot Lisa K. Jennings Dean Kereiakes Dirk Sibbing Die | 2010 | Journal of the American College of Cardiology2010，，12： | 3 |
| 5 | Role of nutraceuticals during the transition period of dairy cows: a review显示文摘The transition period of dairy cattle is characterized by a number of metabolic, endocrine, physiologic, and immune adaptations, including the occurrence of negative energy balance, hypocalcemia, liver dysfunction, overt systemic inflammatory response, and oxidative stress status. The degree and length of time during which these systems remain out of balance could render cows more susceptible to disease, poor reproductive outcomes, and less efficient for milk production and quality. Studies on both monogastrics and ruminants have reported the health benefits of nutraceuticals(e.g. probiotics, prebiotics, dietary lipids, functional peptides, phytoextracts) beyond nutritional value, interacting at different levels of the animal's physiology. From a physiological standpoint, it seems unrealistic to disregard any systemic inflammatory processes. However, an alternate approach is to modulate the inflammatory process per se and to resolve the systemic response as quickly as possible.To this aim, a growing body of literature underscores the efficacy of nutraceuticals(active compounds) during the critical phase of the transition period. Supplementation of essential fatty acids throughout a 2-month period(i.e. a month before and a month after calving) successfully attenuates the inflammatory status with a quicker resolution of phenomenon. In this context, the inflammatory and immune response scenario has been recognized to be targeted by the beneficial effect of methyl donors, such as methionine and choline, directly and indirectly modulating such response with the increase of antioxidants GSH and taurine. Indirectly by the establishment of a healthy gastrointestinal tract, yeast and yeast-based products showed to modulate the immune response, mitigating negative effects associated with parturition stress and consequent disorders.The use of phytoproducts has garnered high interest because of their wide range of actions on multiple tissue targets encompassing a series of antimicrobial, antiviral, antioxidant, immune-stimulating, rumen fermentation, and microbial modulation effects. In this review, we provide perspectives on investigations of regulating the immune responses and metabolism using several nutraceuticals in the periparturient cow. | Vincenzo Lopreiato Matteo Mezzetti Luca Cattaneo Giulia Ferronato Andrea Minuti Erminio Trevisi | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 6 | Hyperhomocysteinemia,atheroclosis and thrombosis显示文摘 | Cattaneo M | 1999 | Thromb Hae most1999，81，2： | 2 |
| 7 | Cost-effective design of agri-environmental payment programs: U.S. experience in theory and practice显示文摘 | Roger Claassen Andrea Cattaneo Robert Johansson | 2007 | Ecological Economics2007，，4： | 2 |
| 8 | Poverty reduction through the development of inclusive food value chains显示文摘Propelled by urbanization,rising incomes,and changing diets,food markets have been expanding in Africa and South Asia,creating the vast potential for job and income opportunities along food supply chains and,hence,for poverty reduction.The novel coronavirus(COVID-19)that spread to a pandemic in early 2020 provokes enormous setbacks to this expansion.This,however,should provide lessons regarding the importance of resilient and inclusive food systems.Emergency responses to COVID-19 should consider interventions towards that end and leverage the opportunities provided by food markets growth as economies recover from the present economic recession.This paper assesses options of how this could be done by facilitating the better functioning and interconnectedness of the many small and medium-sized enterprises that are proliferating along the'hidden middle'of food value chains in storage,logistics,transportation,and wholesale and retail distribution.It also explores how policies can help smallholder farmers connect to this'hidden middle'in more gainful ways and help them climb out of poverty as well. | Rob VOS Andrea CATTANEO | 2021 | Journal of Integrative Agriculture2021，20，4： | 2 |
| 9 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 10 | 足球教练(经理)合同的特性与解除——国际视野下的比较研究显示文摘本文对教练与俱乐部之间的关系以及该关系的解除和后果进行探析。首先概述该论题的总体框架,然后分析国际足联和欧洲足联制定的有关规则。鉴于在绝大多数国家的实践中,相关规则源自合同条款,因此,有必要对合同条款的性质特点予以关注。其次,本文将从国际层面的案例中概览该问题,尤其关注那些由国际足联球员身份委员会和国际体育仲裁院受理的案件。最后,本文将介绍欧盟和国际上一些国家的情况,回顾国内规则、法律问题以及相关案例。 | Lucio Colantuoni Edoardo Revello Andrea Cattaneo 唐勇 吴方圆 | 2015 | 体育科研2015，36，3： | 2 |
| 11 | Survival,integration,and differentiation of neural stem cell lines after transplantation to the adult rat striatum显示文摘 | Lundberg C Martinez-Serrano A Cattaneo E | 1997 | Exp Neurol1997，145，： | 1 |
| 12 | Production of type-1 and type-2 cytokines by peripheral blood mononuclear cells of psoriatic patients 显示文摘 | Mozzanica N Cattaneo A Trabattoni D | 1995 | Immunology1995，86，3： | 1 |
| 13 | Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor显示文摘 | Anacker C Zunszain PA Cattaneo A | 2011 | Mol Psychiatry2011，16，7： | 1 |
| 14 | An XAFS study of the different influ- ence of chelating ligands on the HDN and HDS of y-A12 03 -suppor- ted NiMo catalysts 显示文摘 | Cattaneo R Rota F Prins R | 2001 | Journal of Catalysis2001，199，2： | 1 |
| 15 | Labio-lingual root control of lower anterior teeth and canines obtained by active and passive self-ligating brackets显示文摘 | Cattaneo PM Salih RA Melsen B | 2013 | Angle Orthod2013，83，4： | 1 |
| 16 | BZMV~(dM)algebras and Stonian MV-algebras(applications to fuzzy sets and rough approximations)显示文摘 | Cattaneo G Giuntini R Pilla R | 1999 | Fuzzy Sets and Systems1999，2，： | 1 |
| 17 | Characterization of platinum-rutheniun electrodeposits using XRD, AES and XPS analysis显示文摘 | Cattaneo C Sanchez de Pinto M I Mishima H | 1999 | J Electroanal Chern1999，，： | 1 |
| 18 | Proliferation of isolation CNS blast stem cells regualted by nerve growth factor显示文摘 | Cattaneo E Mckay R | 1990 | Nature1990，374，： | 1 |
| 19 | Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay显示文摘 | Cattaneo MG Pola S Deho V | 2003 | Br J Pharmacol2003，138，2： | 1 |
| 20 | A form of heat conduction equation which eliminates the paradox of instantaneous propagation显示文摘 | Cattaneo C | 1958 | Compute Rendus1958，247，： | 1 |
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