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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Cetuximab plus FOLFIRI:final data from the CRYSTAL study on the association of KRAS and BRAF biomarker status with treatment outcome 显示文摘 | Van CE Lang I Folprecht G | 2010 | J Clin Onco12010，28，15： | 1 |
| 4 | Assessment ofcomplement cleavage in gingival fluid during experimental gingivitis in man显示文摘 | Patters MR Niekrash CE Lang NP | 1989 | J Clin Periodontol1989，16，1： | 1 |
| 5 | Absence of a proximal to distal gradient of motor deficits in the upper extremity early after stroke显示文摘 | Beebe JA Lang CE | 2008 | Clin Neu rophysiol2008，119，9： | 1 |
| 6 | Risk factors for retinal occlusive disease显示文摘 | Lang GE Spraul CE | 1997 | Klin Monatsbl Augenheilkd1997，211，4： | 1 |
| 7 | Use of echocardiography for the phenotypic assessment of genetically altered mice显示文摘 | Collins KA Korcarz CE Lang RM | 2003 | Physiol Genomics2003，13，3： | 1 |
| 8 | Computer-assis- ted operative planning in adult living donor liver transplanta- tion: A new way to resolve the dilemma of the middle hepat- ic vein 显示文摘 | Radtke A Nadalin S Sotiropoulos GC Molmenti EP Schroeder T Valentin-Gamazo C Lang H Bockhorn M Peitgen HO Broelsch CE Malag6 M | 2007 | World Journal of Surgery2007，31，1： | 1 |
| 9 | Exploring expectations forupper-extremity motor treatment in people after stroke: a secondaryanalysis显示文摘 | Prager EM Birkenmeier RL Lang CE | 2011 | Am J Occup Ther2011，65，4： | 1 |
| 10 | Measurement of upper extremity function early after stroke: properties of the action research arm test显示文摘 | Lang CE Wagner JM Dromerick AW | 2006 | Arch Phys Med Rehabil2006，87，12： | 1 |
| 11 | Very Early ConstraintInduced Movement during Stroke Rehabilitation (VECTORS):A single-center RCT显示文摘 | Dromerick AW Lang CE Birkenmeier RL | 2009 | Neurology2009，73，3： | 1 |
| 12 | Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: elec- troanatomic characterization and treatment 显示文摘 | Mesas CE Pappone C Lang CC | 2004 | J Am Coil Cardiol2004，44，： | 1 |
| 13 | Active range of motion predicts upper extremity function 3 months after stroke显示文摘 | BEEBE JA LANG CE | 2009 | Stroke2009，40，5： | 1 |
| 14 | Relationships and responsiveness of six upper ex- tremity function tests during the first six months of recovery after stroke 显示文摘 | Beebe JA Lang CE | 2009 | J Neurol Phys Ther2009，33，2： | 1 |
| 15 | Perceived superiority in close relationships:why it exists and persists显示文摘 | Rusbult CE Lange PV | 2000 | J Pers Soc Psychol2000，79，4： | 1 |
| 16 | High plasma levels of tissue inhibitor of metalloproteinase-1(TIMP-1)and interleukin-8(IL-8)characterize patients prone to ventricular fibrillation complicating myocardial infarction显示文摘 | Elmas E Lang S Dempfle CE | 2007 | Clin Chem Lab Med2007，45，10： | 1 |
| 17 | Use of echocardiography for the phenotypic assessment of genetically altered mice 显示文摘 | Collins KA Korcarz CE Lang RM | 2003 | Physiol Genomics2003，13，3： | 1 |
| 18 | Dilated cardiomyopathy in transgenic mice expressing a dominant- negative CREB transcription factor in the heart 显示文摘 | Fentzke RC Korcarz CE Lang RM | 1998 | J Clin Invest1998，101，11： | 1 |
| 19 | Clin Measurement of upper extremity function early after stroke: properties of the action research arm test显示文摘 | Lang CE Wagner JM Dromerick AW | 2006 | Arch Phys Med Reha- bil2006，87，12： | 1 |
| 20 | The effect of eross-seetional stem shape on the torsional stability of cemented implant components显示文摘 | Kedgley AE Takaki SE Lang P Dunning CE | 2007 | J Biomech Eng2007，129，3： | 1 |
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