|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 2 | Modal energy transfer by thermally induced refractive index gratings in Yb-doped fibers显示文摘Thermally induced refractive index gratings in Yb-doped fibers lead to transverse mode instability(TMI)above an average power threshold,which represents a severe problem for many applications.To obtain a deeper understanding of TMI,the evolution of the strength of the thermally induced refractive index grating with the average output power in a fiber amplifier is experimentally investigated for the first time.This investigation is performed by introducing a phase shift between the refractive index grating and modal interference pattern,which is obtained by applying a pump power variation to the fiber amplifier.It is demonstrated that the refractive index grating is sufficiently strong to enable modal energy coupling at powers that are significantly below the TMI threshold if the induced phase shift is sufficiently large.The experiments indicate that at higher powers,the refractive index grating becomes more sensitive to such phase shifts,which will ultimately trigger TMI.Furthermore,the experimental results demonstrate beam cleaning above the TMI threshold via the introduction of a positive phase shift.This finding paves the way for the development of a new class of mitigation strategies for TMI that are based on controlling the phase shift between the thermally induced refractive index grating and modal interference pattern. | Christoph Stihler Cesar Jauregui Andreas Tünnermann Jens Limpert | 2018 | Light(Science & Applications)2018，7，1： | 5 |
| 3 | Genetic Structure of an Endangered Plant,Antirrhinum microphyllum (Scrophulariaceae):Allozyme and RAPD Analysis显示文摘 | Elena T Jose M I Cesar P | 2003 | American Journal of Botany2003，90，： | 1 |
| 4 | A systematic review and meta -analysis of the use of oral zinc in the treatment of hepatic encephalopathy显示文摘 | CHAVEZ-TAPIA NC CESAR -ARCE A BARRIENTOS -GUTI- ERREZ T | 2013 | Nutr J2013，1274，： | 1 |
| 5 | Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training显示文摘 | Cesar T B Aptekmann N P | | 0，，04： | 1 |
| 6 | Influence of the operating conditions on highly oxidative radicals generation in Fcnton's systems显示文摘 | Cesare C Renato B Tuula T | 2009 | Journal of Hazardous Materials2009，16，1： | 1 |
| 7 | C -jun and CPP32 ( caspase - 3 ) in human pancreatic cancer : relation to cell proliferation and death 显示文摘 | Meggiato T Calabrese F De Cesare CM | 2003 | Pancreas2003，26，1： | 1 |
| 8 | C--jun and cpp32 (caspase3) in human pancreatic cancer z relation to cell prolifera- tion and death显示文摘 | Meggiato T Calabrese F De Cesare CM | 2003 | Pancreas2003，26，1： | 1 |
| 9 | Proportional-integral observer for systems modeled by nond gGraphs 显示文摘 | CESAR P A AHMED R GENEVIEVE D T | 2005 | Simulation modeling practice and theory2005，13，： | 1 |
| 10 | Cardiopulmonary responses to exercise in patients of different age group with conges tive heart failure显示文摘 | Cesar Mde C Montesano F T Diniz R V | 2006 | Arq Bras Cardiol2006，86，1： | 1 |
| 11 | Mortality risk for pa- tients receiving hemodiafihration versus hernodialysis 显示文摘 | Jirka T Cesare S Di Benedetto A | 2006 | Kidney Int2006，70，8： | 1 |
| 12 | Biosorption of heavy metals using rice milling by products, characterization and application for removal of metals from aqueous effluents 显示文摘 | CESAR R T T MARCO A Z A | 2004 | Chemosphere2004，54，： | 1 |
| 13 | Predominant symptoms identify different subgroups in functional dyspepsia显示文摘 | Vincenzo S Cesare T Anna P | 1999 | Am J Gastroenterol1999，94，8： | 1 |
| 14 | Diagnostic imaging of neurotuberculosis显示文摘 | Di Lella GM Cesare A | 1998 | Rays1998，23，： | 1 |
| 15 | Competitive sport, evaluation systems, and just results显示文摘 | Cesar R T | 2005 | Journal of the Philosophy of Sport2005，32，： | 1 |
| 16 | C-jun and cpp32 ( caspase-3 ) in human pancreatic cancer relation to cell proliferation and death显示文摘 | Meggiato T Calabrese F De Cesare CM | 2003 | Pancreas2003，26，1： | 1 |
| 17 | Mortality risk for patients receiving hemodiafiltration versus hemodialysis 显示文摘 | Jirka T Cesare S DiB A | 2006 | Kidney Int2006，70，8： | 1 |
| 18 | Ethanolysis of Refined Soybean Oil Assisted by Sodium and Potassium Hydroxides 显示文摘 | KUCEK K T CESAR -OLIVEIRA M A F WILHELM H M | 2007 | Journal of the American Oil Chemists Society2007，84，4： | 1 |
| 19 | Purification and properties of the xylanase produced by Thermomyces lanuginosus显示文摘 | Cesar T Mrsa V | 1996 | Enzyme Microb Technol1996，19，： | 1 |
| 20 | Tailoring spatiotem- poral light confinement in single plasmonic nanoantennas 显示文摘 | Hanke T Cesar J Vanessa K | 2012 | Nano Letters2012，12，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员