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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Awareness of and attitudes towards infertility and its treatment: a cross-sectional survey of men in a United States primary care population显示文摘以前的研究在不孕的治疗描述了种族、社会经济的不同。象态度和了解那样的耐心的因素可能正在贡献因素。因为主要照顾经常是用作一个条目进药的另外的区域的背景,我们寻求了在主要照顾背景评估人男不孕的态度和了解。做这,我们从在亚特兰大等待房间的二个主要照顾诊所在 210 个人执行了人对人的健康问题的态度的代表性的调查,乔治娅。调查与 closed-ended 问题项目是自我管理的并且是在长度的约 20 min。走近的 310 个人, 210 同意参与并且归还了完成的调查。总的来说, 52% 人说他们是 “ very”或 “ somewhat”熟悉不孕并且 25% 为不孕熟悉了治疗。一些人为男不孕作为治疗听说了外科(21%) 和药(35%) 。有条件的了解和熟悉在高社会经济的地位人是更大的(即有收入 > 的学院毕业生或那些; $100 k 每年) 但是没在 multivariate 分析上由种族不同。对不孕的态度与是更可能的显示不孕是一个严重条件,并且相信它减少的非白种人人一起由种族变化了,到担心不孕一个人的 quality-of-life。因此,了解的缺乏,然而并非否定态度,可以在不孕的治疗贡献以前描述的不同。 | Robert S Gerhard Chad WM Ritenour Michael Goodman Dipak Vashi Wayland Hsiao | 2014 | Asian Journal of Andrology2014，16，6： | 7 |
| 3 | Case of hepatocellular carcinoma in a patient with hereditary tyrosinemia in the post-newborn screening era显示文摘Hereditary tyrosinemia type 1(HT-1) is a metabolic disorder caused by a defect in tyrosine degradation. Without treatment, symptoms of hepatomegaly, renal tubular dysfunction, growth failure, neurologic crises resembling porphyrias, rickets and possible hepatocellular carcinoma can develop. The use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione and early diagnosis through newborn screening initiatives have resulted in a sharp decline in morbidity and mortality associated with this disease. We present a case report of a 7-year-old patient with HT-1 who was born prior to the addition of tyrosinemia to the newborn screening in her birth area. At her time of diagnosis, the patient had developed many of the symptoms associated with her disease, including chronic kidney disease, rickets, and myopathy that left her non-ambulatory. During her initial evaluation, she was also noted to have hepatocellular carcinoma. With cadaveric liver transplantation and nutritional support, her symptoms all either resolved or stabilized. Her case il ustrates the severity of the disease if left untreated, the need for vigilance in populations who do not routinely receive newborn screens, and the markedly improved outcomes in patients following transplant. | Essam M Imseis John S Bynon Chad Thornhill | 2017 | World Journal of Hepatology2017，9，9： | 2 |
| 4 | Design and fabrication of high temperature superconducting field coils for a demonstration DC motor显示文摘 | CHAD H J RICH F S | 1993 | IEEE Trans on Applied Superconductivity1993，，： | 1 |
| 5 | An orderly retreat: Dedifferentiation is a regulated process 显示文摘 | Mariko K Chad S Qikai X | 2004 | PNAS2004，101，1： | 1 |
| 6 | Osteoporosis knowledge, beliefs, and practices among adolescent females显示文摘 | ANDERSON K D CHAD K E SPINK K S | 2005 | J Adolesc Heahh2005，36，4： | 1 |
| 7 | 显示文摘 | Trewyn Brian G Whitman Chad M Lin Victor S Y | 2004 | Nanoletters2004，11，4： | 1 |
| 8 | First flush concepts for suspended and dissolved solids in small impervious watersheds显示文摘 | John J S Chad M C | 2004 | Journal of Environmental Engineering2004，130，： | 1 |
| 9 | Wave-induced pore pressure around a composite breakwater显示文摘 | JENG D S CHAD H LIN Y S | 2001 | Ocean Engineering2001，28，10： | 1 |
| 10 | Laboratory studies to characterize the efficacy of sand capping a coal tar contaminated sediment显示文摘 | Seunghun H Chad T J Linda S l | 2006 | Chemosphere2006，63，10： | 1 |
| 11 | Does trade openness affect the speed of output convergence? some empirical evidence 显示文摘 | David G Chad S | 2006 | Empirical Economics2006，31，： | 1 |
| 12 | Bioleaching of cadmium and nickel from synthetic sediments by Acidithiobacillus ferrooxidans显示文摘 | KIM S D BAE J E PARK H S CHAD K | 2005 | Environmental Geochemistry and Health2005，27，3： | 1 |
| 13 | Calculating national and global ecological footprint time series: resolving conceptual challenges显示文摘 | Mathis Wackernagela Chad Monfredaa Niels B S | 2004 | Land Use Policy2004，21，3： | 1 |
| 14 | Nitrous oxide (N2O) induces 2n gametes in sterile F1 hybrids between Oriental×Asiatic lily (Lilium) hybrids and leads to intergenomic recombination显示文摘 | RODRIGO BARBA-GONZALEZ MILLER CHAD T RAMANNA MUNIKOTE S | 2006 | Euphytica2006，148，： | 1 |
| 15 | Effects of specific monoclonal antibodies to dense granular proteins on the inva sion of Toxoplasma gondii in vitro and in vivo 显示文摘 | CHAD Y SONG I K LEE G S | 2001 | Korean J Parasitol2001，39，3： | 1 |
| 16 | Electrospun Nanofibrous Polyurethane Membrane as Wound Dressing 显示文摘 | KHIL M S CHAD I KIM H Y | 2003 | Journal of Biomedical Material Research Part B2003，67，2： | 1 |
| 17 | Increased host resistance against Pneumocystis carinii pneumonia in gammadelta T-cell-deficient mice:protective role of gamma interferon and CD8+ T cells显示文摘 | Chad S Zheng MQ Erana YG | 2002 | Infect Immun2002，70，： | 1 |
| 18 | Worldwild blackberry production显示文摘 | Bernadine C S John R C Chad E F | 2007 | Hort Technology2007，17，2： | 1 |
| 19 | What Makes Bloggers Share Knowledge? An In- vestigation on the Role of Trust 显示文摘 | Chad S Kim M | 2010 | International Journal of In- formation Management2010，30，5： | 1 |
| 20 | Factors that influence physical activity participa- tion among high - and low - SES youth 显示文摘 | Humbert M L Chad K E Spink K S Muhajarine N Anderson K D Bruner M W | 2006 | Qualitative Health Research2006，，16： | 1 |
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