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| 1 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 2 | Targeted prostate biopsy: value of multiparametric magnetic resonance imaging in detection of localized cancer显示文摘前列腺癌症是在人的第二很普通的癌症,与一最近的年里的世界健康组织全球报导的 110 万个新案例。指导活体检视被用于的 Transrectal 超声(TRUS ) 为超过 2 十年的前列腺癌症的诊断,而是这种技术对癌症通常盲目地点。而且, TRUS 活体检视的假否定的率被报导了象 47% 一样高。Multiparametric 磁性的回声成像(mp-MRI ) 包括 T1 加权、 T2 加权的成像象一样动态提高对比(数据通信设备) 并且散开加权的成像(DWI ) 。mp-MRI 是在前列腺癌症的成像的主要进展,启用可疑损害的指向的活体检视。演变指向的活体检视 techniques—包括的直接在里面厌烦活体检视,认知熔化和基于软件的 MRI 超声(MRI 美国) fusion—与更早的方法相比在癌症察觉导致了好几倍的改进。重要地,临床上重要的癌症的察觉被指向极大地便于,与系统的活体检视相比独自一个。经由 MRI 美国熔化的指向的活体检视可以戏剧性地改变前列腺癌症被诊断并且设法的方法。 | Jesse D Le Jiaoti Huang Leonard S Marks | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 3 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 4 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 5 | Fibrodysplasia ossificans progressiva 显示文摘 | Kaplan F S Le Merrer M Glaser D L | 2008 | Best Pract Res Clin Rheumatol2008，22，1： | 1 |
| 6 | Analysis of translation elongation factors from wheat during development and following heat shock显示文摘 | Gallic D R Le H Caldwell C Browning K S | 1998 | Biochemical and Biophysical Research Communications1998，245，： | 1 |
| 7 | Humoral immune response of flounder to Eduardsiella itarda : the pres- ence of various sizes of immunoglobulins in flounder 显示文摘 | Bang J D Kim J W Le S D | 1996 | Dis Aquat Org1996，26，3： | 1 |
| 8 | Prevalence of the poultry red mite (Dermanyssus gallinae ) in England显示文摘 | Fiddes M D Le Gresley S Parsons D G | 2005 | Vet Rec2005，157，8： | 1 |
| 9 | The somatomedin hypothesis: 2001显示文摘 | Le Roith D Bondy C Yakar S | 2001 | Endocr Rev2001，22，1： | 1 |
| 10 | A long reset-time power-on re- set circuit with brown-out detection capability 显示文摘 | Le H B Do X D Lee S G | 2011 | Circuits and Systems II: Express Briefs IEEE Transactions on2011，58，： | 1 |
| 11 | Plant diversity and generation of ecosystem services at the landscape scale:expert knowledge assessment显示文摘 | Quijas S Jackson LE Maass M Schmid B Raffaelli D Balvanera P | | 0，，： | 1 |
| 12 | The somatomedin hypothesis: 2001显示文摘 | LE ROITH D BONDY C YAKAR S | 2001 | Endocrine Reviews2001，22，1： | 1 |
| 13 | The role of down-slope water and nutrient fluxes in the response of Arctic hill slopes to climate change显示文摘 | Rastetter E B Kwiatkowski B L Le D S | 2004 | Biogeochemistry2004，69，： | 1 |
| 14 | Primary extranodal non-Hodgkin's lymphoma (NHL) : the impact of alternative definitions tested in the Comprehensive Cancer Centre West population-based NHL registry 显示文摘 | Krol A D le Cessie S Snijder S | 2003 | Ann Oncol2003，14，1： | 1 |
| 15 | Postoperative irradiation of minor salivary gland malignancies of the head and neck显示文摘 | Le Q T Birdwell S Terris D J | 1999 | Radiother Oncol1999，52，2： | 1 |
| 16 | The influ-ence of seasonally frozen soil on the snowmelt runoff attwo Alpine sites in southern Switzerland 显示文摘 | Bayard D Hli M S Le Parriaux A | 2005 | Journalof Hydrology2005，309，： | 1 |
| 17 | Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation显示文摘 | Seilhean D Cazeneuve C Thuriès V Russaouen O Millecamps S Salachas F Meininger V Le | | 0，，04： | 1 |
| 18 | Structure - Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors显示文摘 | Zhi - Fu T Le W Kent D S | 2007 | J Med Chem2007，50，： | 1 |
| 19 | New insecticides with ecdysteroidal and juvenile hormone activity显示文摘 | Dhadiaiiats T S Carlson G R Le D P | 1998 | Annu Rev Entomol1998，43，： | 1 |
| 20 | Bone transport techniques in posttrau-matic bone defects显示文摘 | Rigal S Merloz P Le Nen D | 2012 | Orthop TraumatoJ Surg Res2012，1，： | 1 |
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