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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Nitrate in grotmdwater: an isotopic multi-tracer approach显示文摘 | WIDORY D KLOPPMANN W CHERY L | 2004 | Journal of Contaminant Hydrology2004，72，14： | 1 |
| 3 | Guidelines for the primary prevention of stroke:A guideline for heahhcare professionals from the American heart associatioWAmerican stroke association 显示文摘 | Larry B Goldstein Chery D | 2011 | Stroke2011，42，： | 1 |
| 4 | Taxon-specific associations between protozoal and methanogen populations in the rumen and a model rumen system显示文摘 | Richard Sharp Cherie J Ziemer Marshall D Stern | 1998 | FEMS Microbiology Ecology1998，26，1： | 1 |
| 5 | Vascular complications of coronary interventions显示文摘 | Cheri D Sharon VR Jennifer L | 1997 | Heart Lung1997，26，2： | 1 |
| 6 | Vascular complications of coronary intereritions显示文摘 | CHERI D SHARNV R JENNIFR L | 1997 | J Heart Lung1997，26，： | 1 |
| 7 | Nitrate in groundwater: an isotopic multi-tracer approach 显示文摘 | Widory D Kloppmann W Chery L | 2004 | Journal of Contaminant Hydrology2004，72，14： | 1 |
| 8 | Study of plate deformation and stress in subduction processes using two-dimensional numerical models 显示文摘 | Hassani R Jongmans D Chery J | 1997 | Journal of Geophysical Research1997，102，17： | 1 |
| 9 | Development of an 11000-r/min 3500-hp Induction Motor and Adjustable-speed Drive for Refinery Sevicr显示文摘 | Barry M Cheri L Gregory D | 1997 | IEEE TRANSACTION ON INDUSTRY APPLICATION1997，33，3： | 1 |
| 10 | The glycerol channel Fpslp mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae 显示文摘 | WYSOCKIL R CHERY C C WAWRZYCKA D | 2001 | Molecular Microbiology2001，40，： | 1 |
| 11 | Hypertonie saline improves stunned myocardium following transient coronary occlusion in pigs显示文摘 | EMILIO B LOBATO M D CHERI A | 2001 | Anesth Analg2001，92，： | 1 |
| 12 | Vascular complications of coronary intervention显示文摘 | Cheri D Sharn VR Jennifr L | 1997 | Heart Lung1997，26，： | 1 |
| 13 | Characterization of the dynamic ac- tivities of a population of microbubbles driven by pulsed ultra- sound exposure in sonoporation 显示文摘 | Fan ZZ Chen D Cheri X | 2014 | Ultrasound Med Biol2014，40，6： | 1 |
| 14 | Organic inputs for soil fertility management in tropical agroecosystems: application of an organic resource database 显示文摘 | CHERY A P CATHERINE N G ROBERT J D | 2001 | Agriculture Ecosystems and Environment2001，，83： | 1 |
| 15 | Taxon-specific associations between pmtozoal and methanogen populations in the tureen and a model rumen system 显示文摘 | Richard Sharp Cherie J Ziemer Marshall D Stem | 1998 | FEMS Microbiology Ecology1998，26，： | 1 |
| 16 | Study of plate deformation and stress in subduction processes using two-dimensional numerical models 显示文摘 | Hassani R Jongmans D Chery J | 1997 | Journal of Geophysical Research1997，102，17： | 1 |
| 17 | Nitrate in goundwater: an isotopic muhi-wdcer approach 显示文摘 | WIDORY D KLOPPMANN W CHERY L | 2004 | Journal of Contaminant Hydrology2004，72，14： | 1 |
| 18 | Display rules for anger and ag- gression in school-age children 显示文摘 | Underwood M K Coie J D Chery L & Herbsman R | 1992 | Child De- velopment1992，，63： | 1 |
| 19 | Nitrate in groundwater:An isotopic multi-tracer approach显示文摘 | Widory D Kloppmann W Chery L | 2004 | Journal of Contaminant Hydrology2004，72，： | 1 |
| 20 | Vascular complications of coronary interventions显示文摘 | Cheri D Sham VR Jennifr L | 1997 | Heart Lung1997，26，： | 1 |
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