|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | Triiodothyronine levels for risk stratification of patients with chronic heart failure显示文摘 | Alessandro Pingitore Patrizia Landi Maria Chiara Taddei Andrea Ripoli Antonio L’Abbate Giorgio Iervasi | 2005 | The American Journal of Medicine2005，，2： | 2 |
| 3 | Nerve growth factor inhibits apoptoais in memory B lymphocytes via inactivation p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome C release显示文摘 | Torcia M de Chiara G Nencioni L Ammendola S Labardi D Lucibello M | 2001 | J Biol Chem2001，276，39： | 1 |
| 4 | Two-dimensionalHyCoSy with contrast tuned imaging technology and asecond-generation contrast media for the assessment of tubalpatency in an infertility program显示文摘 | Chiara L Valeria S Francesco P | 2009 | Fertil Steril2009，92，3： | 1 |
| 5 | Resuscitation from hemorrhagic shoek: experimental model comparing normal saline, dextran, and hypertonic saline solutions显示文摘 | Chiara O Pelosi P Brazzi L | 2003 | Crit Care Med2003，31，7： | 1 |
| 6 | How the measurementsof a few serum markers can be combined to enhancetheir clinical values in the management of cancer 显示文摘 | Cordero OJ De Chiara L Lemos-Gonzalez Y | 2008 | AnticancerRes2008，28，4： | 1 |
| 7 | Resuscitation from hemorrhagic shock: experimental model comparing normal saline, dextran, and hypertonic saline solutions显示文摘 | Chiara O Pelosi P Brazzi L | 2003 | Crit Care Med2003，31，7： | 1 |
| 8 | Smart cities in Europe显示文摘 | A ndrea Carag l iu Chiara Del Bo PeterNijkamp | 2009 | Ideas2009，98，5： | 1 |
| 9 | Proealeitonin in patients with acute coronary syndromes and cardiogenic shock submitted to percutaneous coronary intervention显示文摘 | Claudio P Chiara L Marco C | 2009 | Intern Emerg Med2009，6，4： | 1 |
| 10 | Protein profile of mature soybean seeds and prepared soybean milk 显示文摘 | Anna L C Giuseppe C Chiara C | 2014 | Agricultural and Food Chemi- stry2014，62，： | 1 |
| 11 | Procalcitonin in acute car- diac patients显示文摘 | Claudio P Chiara L Serafina V | 2011 | Intern Emerg Med2011，6，3： | 1 |
| 12 | Automated headspace solid-phase dynamic extraction to analyse the volatile fraction of food matrices显示文摘 | CARLO B CHIARA C ERIEA L | 2004 | Journal of Chromatography A2004，1024，： | 1 |
| 13 | Triiodothyronine levels for risk stratification of patients with chronic heart failure显示文摘 | Alessandro Pingitore Patrizia Landi Maria Chiara Taddei Andrea Ripoli Antonio L’Abbate Giorgio Iervasi | 2005 | The American Journal of Medicine2005，，2： | 1 |
| 14 | Synthesis of the aminocyclopentitol moieties of the hopanoids of Zy- momonas mobilis and Anacystis Montana 显示文摘 | Chiara J L de Gracia I S Bastida A | 2003 | Chem Comm2003，15，： | 1 |
| 15 | Diclofenac nanosuspensions: Influence of preparation procedure and crystal form on drug dissolution behaviour显示文摘 | Francesco L Chiara S Guido E | 2009 | Int J Pharm2009，373，12： | 1 |
| 16 | Fenoldopam in newborn patients undergoing cardiopulmonary bypass: controlled clinical trial 显示文摘 | Ricci Z Stazi GV Chiara L | 2008 | Interact Cardiovasc Thorac Surg2008，7，6： | 1 |
| 17 | Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus显示文摘 | Rajinder S Chiara L Shylaja J | 2001 | Carcinogenesis2001，22，8： | 1 |
| 18 | Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure显示文摘 | Daniela Giannessi Chiara Caselli Silvia Del Ry Maristella Maltinti Silvia Pardini Stefano Turchi Manuela Cabiati Tiziana Sampietro Nader Abraham Antonio L’Abbate Danilo Neglia | 2011 | Metabolism2011，，2： | 1 |
| 19 | Molecular aspects of milk allergens and their role in clinical events 显示文摘 | PATRIZIA R CINZIA B CHIARA D L | 2009 | Anal Bioanal Chem2009，395，： | 1 |
| 20 | Cerebral blood flow during ear- diopulmonary bypass in pediatric cardiac surgery: the role of transcm- nial Doppler--a systematic review of the literature 显示文摘 | Polite A Ricci Z Di Chiara L | 2006 | Cardiovasc Ultrasound2006，13，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员