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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | T-DNA tagged knockout mutation of rice OsGSK1, an orthologue of Arabidopsis BIN2, with enhanced tolerance to various abiotic stresses 显示文摘 | Koh S Lee S C Kim M K Koh J H Lee S An G Choe S Kim S R | 2007 | Plant Molecular Biology2007，65，4： | 1 |
| 3 | CIY24, a novel cancer biomarker, predicting disease -free survival ofnon - small cell lung carcinomas : a retrospective study of prognos- tic factor analysis from the viewpoint of forthcoming(seventh) new TNM classification显示文摘 | Lee HJ Choe G Jheon S | 2010 | J Thorac Onco12010，5，5： | 1 |
| 4 | The crystal structure of diphtheria toxin 显示文摘 | Choe S Bennett MJ Fujii G | 1992 | Nature1992，357，6375： | 1 |
| 5 | Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells 显示文摘 | Kim G Choe Y Park J Cho S Kim K | 2002 | Mol Brain Res2002，109，12： | 1 |
| 6 | Electrochemical characteristics of osteoblast cultured Ti-Ta alloy for dental implant显示文摘 | KIM W G CHOE H C KO Y M | 2007 | Advanced Material Research2007，26，： | 1 |
| 7 | A new simulation model of PMSM motor with real back EMF waveform显示文摘 | | 2000 | Proceeding from Computers in Power Electronics2000，，1618： | 1 |
| 8 | Reduce the epidural with Bupivacain verapamil after lower Addominal Region Surgery 显示文摘 | Kehiet H Varrassi G | 1998 | Anesth Analg1998，86，： | 1 |
| 9 | Sediment-water exchange of total mercury and monomethyl in the San Francisco Bay-Delta显示文摘 | Choe K Y Gill G A Lehman R D | 2004 | Limnology and Oceanography2004，49，： | 1 |
| 10 | The crystal structure of diphtheria toxin显示文摘 | Choe S Bennett M Fujii G | 1992 | Nature1992，357，： | 1 |
| 11 | Spinal intraosseous schwan- noma: a case report and review 显示文摘 | Park S C Chung S K Choe G | 2009 | J Korean Neurosurg Soc2009，46，4： | 1 |
| 12 | Structural analysis for lightweight design of a seat frame in automotive vehicles显示文摘 | Kirn H G Choe G H | 2000 | Kry Engineering Materials2000，177，180： | 1 |
| 13 | The crystal strure of diphtheria toxin显示文摘 | Choe S Bennett M Fujii G | 1992 | Nature1992，357，： | 1 |
| 14 | Growth patterns of craniopharyngi-oma in children: role of the diaphragm sellae and its surgical implica-tion 显示文摘 | Wang KC Kim SK Choe G | 2002 | Surgical Neurology2002，57，1： | 1 |
| 15 | Molecular analysis of rice plant sharboring an Ac/Ds transposable element mediated gene-trapping system显示文摘 | Chin H G Choe M S Lee S H | 1999 | Plant Journal1999，19，5： | 1 |
| 16 | S100A4 expression is as- sociated with lymph node metastasis in papillary microcar- cinoma of the thyroid显示文摘 | Min HS Choe G Kim SW | 2008 | Mod Pathol2008，21，6： | 1 |
| 17 | 显示文摘 | Zheng M Choe G Johnson K E | 2002 | IEEE Trans Magn2002，38，5： | 1 |
| 18 | Constrained-film sintering of a goldcircuit paste 显示文摘 | CHOE J W CALAT J N LU G Q | 1995 | J Mater Res1995，3，8： | 1 |
| 19 | Pattern recognition显示文摘 | Choe G B | 1993 | Elsevier Science Inc1993，26，12： | 1 |
| 20 | The Miocene Doumsan fan deltaSoutheast Korea: a composite fan delta system in back arc margin显示文摘 | Chough S K Hwang I G Choe M Y | 1990 | Journal of Sedimentary Petrology1990，60，3： | 1 |
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