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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Multi-criteria fuzzy decision-making problems based on vague set theory显示文摘 | Hong D H Choi C H | 2000 | Fuzzy Sets and Systems2000，114，： | 2 |
| 3 | Evaluation of seismic performance of multistory building structures based on the equivalent responses 显示文摘 | LEE D G CHOI W H CHEONG M C | 2006 | Engineering Structures2006，28，6： | 1 |
| 4 | Multicriteria fuzzy decision-making problems based on vague set theory显示文摘 | HONG D H CHOI C H | 2000 | Fuzzy Sets and Systems2000，114，1： | 1 |
| 5 | The TGF-β-smad net-work:introducing bioinformatic tools显示文摘 | Kloos D U Choi C Wingender E | 2002 | Trends in Gene-ties2002，18，： | 1 |
| 6 | Prevalence,Capsular Type and Antimicrobial Susceptibility of Streptococcus suis Isolated from Slaughter Pigs in Korea显示文摘 | Han D U Choi C Ham H J | 2001 | Can J Vet Res2001，65，3： | 1 |
| 7 | Ischemic tolerance in murine cortical cell culture:critical role for NMDA receptors显示文摘 | Grabb M C Choi D W | 1999 | J Neurosci1999，19，5： | 1 |
| 8 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 9 | Bin2 is a transcription factor regulating keratinocyte differentiation with a possible role in the pathogenesis of lichen planus 显示文摘 | Shi Sohn K C Choi D K | 2010 | PLoS One2010，5，10： | 1 |
| 10 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 11 | Aspiration thrnmhectomy of a cute complete carotid bulb occlusion显示文摘 | Xu G F Suh D C Choi C G el al | 2005 | J Vase Intt rv Radiol2005，16，4： | 1 |
| 12 | Analgesic effect of acupuncture is mediated via inhibition of JNK activation in astrocytes after spinal cord injury显示文摘 | Lee J Y Choi D C Oh T H | 2013 | Plo S one2013，8，73： | 1 |
| 13 | Adipocytokine signaling is altered in Flinders sensitive line rats, and adiponectin correlates in humans with some symptoms of depression 显示文摘 | Wilhelm C J Choi D Huckans M | 2013 | Pharmacology Biochemistry Behavior2013，103，3： | 1 |
| 14 | Anaplastie thyroid carcinoma: computed tomographic differentiation from other thyroid masses 显示文摘 | Lee J W Yoon D Y Choi C S | 2008 | Aeta Radiol2008，49，3： | 1 |
| 15 | A new simplified space-vector PWM method for three-level inverters 显示文摘 | Seo J H Choi C H Hyun D S | 2001 | IEEE Trans on Power Electronics2001，16，7： | 1 |
| 16 | Isoliquiritigenin selectively inhibits H(2) histamine receptor signaling显示文摘 | KIM D C CHOI S Y KIM S H | 2006 | Mol Pharmacol2006，70，2： | 1 |
| 17 | Review of metastatic spine tumour classification and indications for surgery: the consensus statement of the Global Spine Tumour Study Group 显示文摘 | Choi D Crockard A Bunger C | 2010 | Eur Spine J2010，19，2： | 1 |
| 18 | An environment-friendly surface pretreatment of ABS plastic for electroless plating using chemical foaming agents 显示文摘 | KANG D H CHOI J C CHOI J M | 2010 | Transactions on Electrical and Electronic Materials2010，11，4： | 1 |
| 19 | Er2Al2 codoped silicate planarlight waveguide2type amplifier fabricated by radio2frequency souttering显示文摘 | Choi YB Cho S H Moon D C | 2000 | Optics Lett2000，25，4： | 1 |
| 20 | Two-sur- face soil constitutive model calibration for coarse granular materials显示文摘 | CHOI C ARDUINO P HARNEY M D | 2005 | Calibration of Constitutive Models2005，67，2： | 1 |
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