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154篇 您的检索式:作者名="CHRISTIE A M"
    题名 作者 年代 出处 被引量
1Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns 2015World Journal of Gastroenterology2015,21,17:4
2Selection of new Kynarbased electrolytes for lithium-ion batteries显示文摘Christie A M Christie L Vincent C A 1998J Power Sources1998,74,1:1
3Maturity determination of organic matter in coals using the methylphenanthrene distribution显示文摘Kvalhem O M Christy A A Telnaes N 1987Geochimica et Cosmochimica Acta1987,51,7:1
4Comparisons of empirical viscous-fingering models and their calibration for heterogeneous problems 显示文摘Fayers F J Blunt M J Christie M A 1992SPE 221841992,,:1
5Soil solution Zn and pH dynamics in nonrhizosphere soil and in the rhizosphere of Thlaspi caerulescens grown in a Zn/Cd contaminated soil 显示文摘Luo Y M Christie P Baker A J M 2000Chemosphere2000,41,:1
6The use of lightweight expanded clay aggregate (LECA) as sorbent for PAHs removal from water 显示文摘Nkansah M A Christy A A Barth T 2012Journal of Hazardous Materials2012,,:1
7Decentralization of the firm:theory and evidence显示文摘CHRISTIE A A JOYE M P WATTS R L 2003Journal of Corporate Finance2003,9,1:1
8Flavonoid supplement improves leg health and reduces fluid retention in pre-menopausal women in a double-b/ind, placebo-controlled study显示文摘CHRISTIE S WALKER A F HICKS S M 2004Phytomexiicine2004,11,1:1
9Upscaling for reservoir simulation 显示文摘Christie M A 1996SPE 373241996,,:1
10Aeroponics-aproduction system and research tool显示文摘Christie C B Nichols M A 2004Acta Horticulturae2004,648,:1
11Non- saphenofemoral venous reflux in the groin in patients with varicose veins 显示文摘JIANG P VAN RIJ A M CHRISTIE R A 2001Eur J Vasc Endovasc Surg2001,21,6:1
12Autoantibodies to GAD arid IA-2 in Saudi Arabian diabetic patients 显示文摘Damanhouri L H Dromey J A Christie M R 2005Diabetic Medicine2005,22,4:1
13Simultaneous Determination of Residues of Chloramphenicol, Thiamphenicol, Florfenicol and Florfenicol Amine in Farmed Aquatic Species by Liquid Chromatography - Mass Spectrometry 显示文摘Jeffery M van de Riet Ross A Potter Melissa Christie Fougere 2003Journal of AOAC InternatiOnal2003,86,3:1
14Ca- thodic limitations in microbial fuel ceils: An overview 显示文摘Rismani - Yazdi H Carver S M Christy A D 2008Journal of Power Sources2008,180,:1
15Flow stress from microstructures of mylonites: Example and current assessment显示文摘Christie J M Ord A 1980Geophy Res1980,,:1
16Effect of water on the rheology of experimentally deformed quartz- ite 显示文摘KOCH P S CHRISTIE J M ORD A 1989J Geophys Res1989,94,13:1
17Maturity determination of organic matter in coals using the methylphenanthrene distribution显示文摘Kvalheim O M Christy A A Telns N 1987Geochimica et Cosmochimica Acta1987,51,7:1
18Selection of new Kynar-based electrolytes for lithium-ion batteries显示文摘Christie A M Christie L Vincent C A 1998J Power Sources1998,74,1:1
19PHLDA1 expression marks the putative epithelial stem cells and contributes to intestina tumorigenesis显示文摘Sakthianandeswaren A Christie M D'Andreti C 2011Cancer Res2011,71,10:1
20Petroleum resources of the Mackenzie Delta and Beaufort Sea显示文摘Dixon J Morrel G R Dietrich J R Taylor G C Procter R M Conn R F Dallair S M Christie J A 1994Geological Survey of Canada Bulletin1994,474,:1
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