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| 1 | Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia显示文摘BACKGROUND: Chronic hepatitis C virus(HCV) infection is associated with autoimmune phenomena and is often complicated by anemia. Circulating autoantibodies to endogenous erythropoietin(anti-EPO) have been detected in patients with chronic viral infections and were correlated to anemia. The present study aimed to determine anti-EPO prevalence in patients with chronic HCV infection and investigate its possible association with anemia.METHODS: Ninety-three consecutive patients(62 males and 31 females) with chronic HCV infection, who had never received antiviral therapy or recombinant EPO, were enrolled in the study. Circulating anti-EPO were detected in the serum by using an ELISA assay. Quantitative determination of serum EPO levels was done by radioimmunoassay. HCV RNA viral load measurement and genotype sequencing were also performed.RESULTS: Circulating anti-EPO were detected in 10.8% of HCV-infected patients and the prevalence of anti-EPO was significantly higher in patients with anemia(19.4% vs 5.3%, P=0.040) compared to that in those without anemia. Compared to anti-EPO negative cases, anti-EPO positive patients had higher frequency of anemia(70.0% vs 34.9%, P=0.030), lower EPO concentrations(median 16.35 vs 30.65 m U/m L, P=0.005), and higher HCV RNA viral load(median 891.5×103 vs 367.5×103 IU/m L, P=0.016). In multivariate regression analysis the presence of anti-EPO remained an independent predictor of anemia(adjusted OR: 14.303, 95% CI: 1.417-36.580, P=0.024). EPO response to anemia was less prominent among anti-EPO positive patients(P=0.001).CONCLUSIONS: Circulating anti-EPO are detected in a significant proportion of treatment-na?ve HCV-infected patients and are independently associated with anemia, suggesting a further implication of autoimmunity in the pathophysiology of HCV-related anemia. | Aristotelis Tsiakalos Theoharis Voumvas Alexandros Psarris Christina K Oikonomou Dimitrios C Ziogas Ioannis Ketikoglou Grigorios Hatzis Nikolaos V Sipsas | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 4 |
| 2 | The prevalence of bcl- 2, p53, and ki67 immunoreactivity in transitional cell bladder carcinomas and their clinicopathologic correlates 显示文摘 | Lydia N Christina V Anastasios Z | 1996 | Hum Pathol1996，29，： | 1 |
| 3 | Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and clAP1 in situ显示文摘 | Christina R Mihnea V Michael P | 2002 | Biol Chem2002，277，5： | 1 |
| 4 | Behaviors of inorganic matterduring heating of Bulgarian coals显示文摘 | Christina G V Stanislav V V | 2005 | Fuel Processing Tech-nology2005，86，： | 1 |
| 5 | Behavior of dements and minerals during preparation and combustion of the Pernik coal显示文摘 | Vassileva Stanislav V Eskenazy Greta M Vassileva Christina G | 2001 | Fuel Processing Technology2001，72，2： | 1 |
| 6 | Looking to the future: developments in preimplantation genetic diagnosis显示文摘 | Jan TS Georgia K Christina V | 2012 | Obstet Gynecol2012，7，4： | 1 |
| 7 | 显示文摘 | Stanislav V Vassilev Christina G Vassilev | 2005 | International Journal of Coal Geology2005，61，： | 1 |
| 8 | The development of re- sponse selection accuracy in a football linebacker using video train- ing 显示文摘 | Christina R W Barresi J V Shaffner P | 1990 | The Sport Psychologist1990，，4： | 1 |
| 9 | A new approach for the classification of coal fly ashes based on their origin composition,properties and behavior显示文摘 | Stanislav V V Christina G V | 2007 | Fuel2007，86，1011： | 1 |
| 10 | Human tissue kallikrein gene family:applications in cancer显示文摘 | Christina V Obiezu Eleftherios P Diamandis | 2005 | Cancer Letters2005，224，： | 1 |
| 11 | Prevalence of Raynaud's phenomenon in a healthy Greek population显示文摘 | Paraskevi V Voulgari Yannis Alamanos Damiani Papazisi Konstantinos Christou Christina Papanikolaou Alexandros A Drosos | 2000 | Ann Rheum Dis2000，59，： | 1 |
| 12 | Behavior of elements and minerals during preparation and combustion of the Pernik coal显示文摘 | Vassileva Stanislav V Eskenazy Greta M Vassileva Christina G | 2001 | Fuel Processing Technology2001，72，2： | 1 |
| 13 | Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate显示文摘AIM: To evaluate the feasibility of using therapeutic ultrasound as an alternative treatment option for organconfined prostate cancer. METHODS: In this study, a trans-urethral therapeutic ultrasound applicator in combination with 3T magnetic resonance imaging(MRI) guidance was used for realtime multi-planar MRI-based temperature monitoring and temperature feedback control of prostatic tissue thermal ablation in vivo. We evaluated the feasibility and safety of MRI-guided trans-urethral ultrasound to effectively and accurately ablate prostate tissue while minimizing the damage to surrounding tissues in eight canine prostates. MRI was used to plan sonications, monitor temperature changes during therapy, and to evaluate treatment outcome. Real-time temperature and thermal dose maps were calculated using the proton resonance frequency shift technique and were displayed as two-dimensional color-coded overlays on top of the anatomical images. After ultrasound treatment, an evaluation of the integrity of cavernosal nerves was performed during prostatectomy with a nerve stimulator that measured tumescence response quantitatively and indicated intact cavernous nerve functionality. Planned sonication volumes were visually correlated to MRI ablation volumes and corresponding histo-pathological sections after prostatectomy. RESULTS: A total of 16 sonications were performed in 8 canines. MR images acquired before ultrasound treatment were used to localize the prostate and to prescribe sonication targets in all canines. Temperature elevations corresponded within 1 degree of the targeted sonication angle, as well as with the width and length of the active transducer elements. The ultrasound treatment procedures were automatically interrupted when the temperature in the target zone reached 56 ℃. In all canines erectile responses were evaluated with a cavernous nerve stimulator post-treatment and showed a tumescence response after stimulation with an electric current. These results indicated intact cavernous nerve functionality. In all specimens, regions of thermal ablation were limited to areas within the prostate capsule and no damage was observed in periprostatic tissues. Additionally, a visual analysis of the ablation zones on contrast-enhanced MR images acquired post ultrasound treatment correlated excellent with the ablation zones on thermal dose maps. All of the ablation zones received a consensus score of 3(excellent) for the location and size of the correlation between the histologic ablation zone and MRI based ablation zone. During the prostatectomy and histologic examination, no damage was noted in the bladder or rectum.CONCLUSION: Trans-urethral ultrasound treatment of the prostate with MRI guidance has potential to safely, reliably, and accurately ablate prostatic regions, while minimizing the morbidities associated with conventional whole-gland resection or therapy. | Steffen Sammet Ari Partanen Ambereen Yousuf Christina L Sammet Emily V Ward Craig Wardrip Marek Niekrasz Tatjana Antic Aria Razmaria Keyvan Farahani Shunmugavelu Sokka Gregory Karczmar Aytekin Oto | 2015 | World Journal of Radiology2015，7，12： | 1 |
| 14 | Endocrine disruptors in the environment and their impact on human health 显示文摘 | Cristina P Christina UM Carmen V | 2012 | EnvironEngin Manage J2012，11，9： | 1 |
| 15 | Management of Patients With ST ‐Segment Elevation or Non– ST ‐Segment Elevation Acute Coronary Syndromes in Cardiac Rehabilitation Centers显示文摘 | Rona Reibis Heinz V?ller Anselm Gitt Christina Jannowitz Martin Halle David Pittrow Steven Hildemann | 2014 | Clin Cardiol2014，，4： | 1 |
| 16 | The German way to greenways and habitat networks显示文摘 | CHRISTINA V H MICHAEL R | 2006 | Landscape and Urban Planning2006，76，14： | 1 |
| 17 | Hepcidin,a urinary antimierobial peptide synthesized in the liver显示文摘 | CHRISTINA H P ERIKA V V ALAN J W | 2001 | Biologieal Chemistry2001，276，11： | 1 |
| 18 | Switchable holographic polymer-dispersed liquid crystal reflection gratings based on thiol ene photopolymeri- zation显示文摘 | Lalgudi V Natarajan Christina K Shepherd Donna M Bran- delik | 2003 | Chem Mater2003，15，12： | 1 |
| 19 | Diabetic cardiomyopathy:from thepathophysiology of the cardiac myocytesto current diagnosis and management strategies显示文摘 | Christina V Dimitrios P Nicholas T | | 0，，： | 1 |
| 20 | Improving cash flow through accounts receivables financing 显示文摘 | VORT V CHRISTINA | 2014 | Medical economics2014，，6： | 1 |
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