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| 1 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 2 | Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency 显示文摘 | Boyanov M A Boneva Z Christov V G | 2003 | Aging Male2003，6，1： | 1 |
| 3 | Numerical study of patterns and their evolution in finite geometries显示文摘 | PONTES J CHRISTOV C I VELARDE M G | 1996 | Inter J of Bifur and Chaos1996，6，10： | 1 |
| 4 | Cell proliferation,apoptosis,and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors显示文摘 | Christov K Ikui A Shilkaitis A | 2003 | Breast Cancer Res Treat2003，77，3： | 1 |
| 5 | Propagation of ultrashort pulses in gaseous medium: breakdown of the quasistatic approximation显示文摘 | Christov I P | 2000 | Optics Express2000，6，： | 1 |
| 6 | Antibacterial furofuran lignans from Canary Islands propolis 显示文摘 | Christov R Bankova V Tsvetkova I et at | 1999 | Fitoterapia1999，70，6： | 1 |
| 7 | Central-upwindschemes for the boussinesq paradigm equations 显示文摘 | Chertock A Christov C I Kurganov A | 2011 | Computational Science and High Performance ComputingIV NNFM2011，113，： | 1 |
| 8 | Testosterone supplementation in men with type 2 diabetes,visceral obesity and partial androgen deficiency显示文摘 | Boneva Z Christov VG | 2003 | Aging Male2003，6，1： | 1 |
| 9 | High-pressure fluid phase equilibria experimental methods and systems investigated (1994-1999) 显示文摘 | Christov M Dohrn R | 2002 | Fluid Phase Equilibria2002，202，： | 1 |
| 10 | Filtering of electromyography artifacts from the electrocardiogram 显示文摘 | IVAYLO I CHRISTOV IVANK | 1999 | Med Engineering physics1999，21，： | 1 |
| 11 | Capillary mechanisms in membrane emulsification: oil- in-water emulsions stabilized by Tween 20 and milk proteins显示文摘 | Christov N C Ganchev D N Vassileva N D | 2002 | Colloid Surf B2002，209，： | 1 |
| 12 | Adsorption and inhibitive properties of benzimidazole derivatives in acid mild steel corrosion显示文摘 | A Popova M Christov S Raicheva E Sokolova | 2003 | Corrosion Science2003，，6： | 1 |
| 13 | Muscle satellite cells and endothelial ceils: close neighbors and privileged partners 显示文摘 | Christov C Chr6tien F Abou-Khalil R | 2007 | Mol Biol Cell2007，18，4： | 1 |
| 14 | Gas Chromatographic Analysis of Underivatized Phenolic Constituents from Propolis Using an Electron-capture Detector显示文摘 | Christov R Bankova V | 1992 | J Chromatogr1992，623，1： | 1 |
| 15 | Electrocardiogram signal preprocessing for automatic detection of QRS boundaries显示文摘 | DASKALOV I K CHRISTOV I I | 1999 | Med Eng Phys1999，21，1： | 1 |
| 16 | Production, partial characterization and use of fungal cellulase-freexylanases in pulp bleaching显示文摘 | Christov L P Szakacs G Balakrishnan C H | 1999 | Process Biochemistry1999，34，： | 1 |
| 17 | Effect of matrix on (S)-p-chlorodiphenylmethanol production by immobilized Debaryomyces marama显示文摘 | Christov P Spassov G Pramatarova V | 1999 | Process Biochemistry1999，34，： | 1 |
| 18 | Capillary mechanisms in membrane emulsification:oil-inwater emulsions stabilized by Tween 20 and milk proteins显示文摘 | Christov N C Ganchev D N Vassileva N D | 2002 | Colloid Surf B2002，209，： | 1 |
| 19 | High-pass filtering of the electrogastrogram显示文摘 | Professor I. Daskalov I. Christov V. Kolev | 1997 | Medical & Biological Engineering & Computing1997，，3： | 1 |
| 20 | Chemical composition and antibacterial activity of Brazilian propolis显示文摘 | BANKOVA V CHRISTOV R KUJUMGIEV A | 1995 | ZNaturforsch1995，50，34： | 1 |
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