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| 1 | Liver fibrosis markers in alcoholic liver disease显示文摘Alcohol is one of the main factors of liver damage. The evaluation of the degree of liver fibrosis is of great value for therapeutic decision making in patients with alcoholic liver disease(ALD). Staging of liver fibrosis is essential to define prognosis and management of the disease. Liver biopsy is a gold standard as it has high sensitivity and specificity in fibrosis diagnostics. Taking into account the limitations of liver biopsy, there is an exigency to introduce non-invasive serum markers for fibrosis that would be able to replace liver biopsy. Ideal serum markers should be specific for the liver, easy to perform and independent to inflammation and fibrosis in other organs. Serum markers of hepatic fibrosis are divided into direct and indirect. Indirect markers reflect alterations in hepatic function, direct markers reflect extracellular matrix turnover. These markers should correlate with dynamic changes in fibrogenesis and fibrosis resolution. The assessment of the degree of liver fibrosis in alcoholic liver disease has diagnostic and prognostic implications, therefore noninvasive assessment of fibrosis remains important. There are only a few studies evaluating the diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with ALD. Several noninvasive laboratory tests have beenused to assess liver fibrosis in patients with alcoholic liver disease, including the hyaluronic acid, FibroTest, FibrometerA, Hepascore, Forns and APRI indexes, FIB4, an algorithm combining Prothrombin index(PI), α-2 macroglobulin and hyaluronic acid. Among these tests, Fibrotest, FibrometerA and Hepascore demonstrated excellent diagnostic accuracy in identifying advanced fibrosis and cirrhosis, and additionally, Fibrotest was independently associated with survival. Therefore, the use of biomarkers may reduce the need for liver biopsy and permit an earlier treatment of alcoholic patients. | Lech Chrostek Anatol Panasiuk | 2014 | World Journal of Gastroenterology2014，20，25： | 6 |
| 2 | Alcohol and risk for the vancer显示文摘 | CHROSTEk L SZMITKOWSKI M | 2003 | Pol Merkuriusz Lek2003，15，89： | 1 |
| 3 | Depth of thermal injury:ultrasonically activated scalpel versus electrosurgery显示文摘 | Amaral JF Chrostek C | 1995 | Surg Endosc1995，9，： | 1 |
| 4 | The activity of class I,Ⅲ,and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in gastric cancer显示文摘 | Jelski W Chrostek Lech Szmitkowski M | 2007 | Dig Dis Sci2007，52，： | 1 |
| 5 | Alcohol and aldehyde dehydrogenase activity in the stomach and small intestine of rats poisoned with methanol显示文摘 | Chrostek L Szczepura D Szmikowski M | 2001 | Hum Exp Toxicol2001，20，5： | 1 |
| 6 | Serum total and free sialic acid in patients with chronic liver disease显示文摘 | Cylwik B Chrostek L Panasiuk A | 2010 | Clin Chem Lab Med2010，48，： | 1 |
| 7 | Lipid-bound sialic acid (LSA) in liver diseases of different etiologies显示文摘 | Chrostek L Cylwik B Panasiuk A | 2011 | Ann Hepatol2011，10，： | 1 |
| 8 | The activity of class Ⅰ, Ⅱ, Ⅲ,and IV of alcohol dehydrogenase isoeazymes and aldehydedehy dr ogenase in pancreatic cancer 显示文摘 | Jelski W Chrostek L Szmitkowski M | 2007 | Pancreas2007，35，2： | 1 |
| 9 | Laparosonic coagulating shears:al- temative method of hemostatic control of unsupported tissue显示文摘 | Hoenig DM Chrostek CA Amaral JF | 1996 | J En- dourol1996，，10： | 1 |
| 10 | The assessment of serum soluble transferrin receptor in alcoholics显示文摘 | Bogdan Cylwik Lech Chrostek Marta Daniluk | 2010 | Clin Exp Med2010，10，： | 1 |
| 11 | Disturbances of folic acid and homocysteine me- tabolism in alcohol abuse 显示文摘 | Cylwik B Chrostek L | 2011 | Pol Merkur Lekarski2011，30，178： | 1 |
| 12 | Human aicohol dehydrongenase isoenzyme activity in the sera of nonalcoholic Liver cirrhotic patients显示文摘 | Chrostek L Szmitkowski M | 1996 | Eur J Clin Chem Clin Biochem1996，34，10： | 1 |
| 13 | Laparosonic coagula- ting shears:alternative method of hemostatic control of unsup- ported tissue显示文摘 | Hoenig DM Chrostek CA Amaral JF | 1996 | J Endourol1996，10，5： | 1 |
| 14 | Laparosonic coagulatings sears:alternative method of hemostatic control of unsupported tissue显示文摘 | Hoenig DM Chrostek CA Amaral JF | 1996 | J Endourol1996，10，5： | 1 |
| 15 | Effect of body iron stores in the indicators of alcohol abuse and alcoholic liver injury显示文摘 | Cylwik B Daniluk M Chrostek L | | 0，，168： | 1 |
| 16 | The assessment of serum soluble transferrin receptor in alcoholics显示文摘 | Cylwik B Chrostek L Daniluk M | | 0，，01： | 1 |
| 17 | Activity of en zymes with different subcellular localization in the blood plas- ma of patients with aortic aneurysm 显示文摘 | Gacko M Ostapowicz R Chrostek L | 2005 | Medical Science Mo- nitor2005，11，4： | 1 |
| 18 | The effect of alcohol on iron metabolism显示文摘 | Cylwik B Chrostek L Szmitkowski M | | 0，，144： | 1 |
| 19 | Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH)activity in the sera of patients with colorectal cancer显示文摘 | Jelski W Zalewski B Chrostek L | 2007 | Clin Exp Med2007，7，4： | 1 |
| 20 | Laparosonic coagulating shears:alternative method of hemostatic control of unsupported tissue显示文摘 | Hoenig DM Chrostek CA Amaral JF | 1996 | J Endourol1996，10，5： | 1 |
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