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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Comparison of in vivo and in vitro efficacy of ceftizoxime 显示文摘 | Delaney M L Cisneros R L | 1990 | Clin Ther1990，12，： | 2 |
| 3 | Efficacy of different irrigation and activation systems on the penetration of sodium hypochlorite into simulated lateral canals and up to working length:an in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | | 0，，07： | 1 |
| 4 | Efficacy of different irrigation and activation systems on the penetra- tion of sodium hypochlorite into simulated lateral canals and up to working length: An in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | 2010 | J Endod2010，36，7： | 1 |
| 5 | Association of the CT gene (CA) polymorphism with BMD in osteoporotic mexican women显示文摘 | Maga a JJ G mez R Cisneros B | 2006 | Clin Genet2006，70，： | 1 |
| 6 | Synthesis of novel highly reactive silicone-epoxy mono- mers for cationic photopolymerizations 显示文摘 | ORTIZ R A de LOURDES GUILLIN CISNEROS M GARCIA G A | 2005 | Polymer2005，46，10： | 1 |
| 7 | Sorption of americium in tuff and pure minerals using synthetic and natural groundwaters显示文摘 | TRIAY I R MEIJER A CISNEROS M R | 1991 | Radiochimica Acta1991，5253，： | 1 |
| 8 | Matrix metalloproteinasesinhibition attenuates tobacco smoke - induced emphysema in guinea pigs 显示文摘 | Selman M Cisneros - Lira J Gaxiola M Ramirez R Kudlacz E M Mitchell P G Pardo A | 2003 | Chest2003，123，5： | 1 |
| 9 | Internal jugular vein valve in- competence is highly prevalent in transient global amnesia 显示文摘 | Cejas C Cisneros LF Lagos R | 2010 | Strnke2010，41，1： | 1 |
| 10 | Effect of EDTA,sonic,and ultrasonic activation on the penetration of sodium hy-pochlorite into simulated lateral canals:an in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | 2009 | JEndod2009，35，6： | 1 |
| 11 | Efficacy of differ-ent irrigation and activation systems on the penetration of sodiumhypochlorite into simulated lateral canals and up to workinglength:an in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | 2010 | J Endod2010，36，7： | 1 |
| 12 | Internal jugular vein valve incompetence is highly prevalent in transient global amnesia显示文摘 | Cejas C Cisneros LF Lagos R | | 0，，01： | 1 |
| 13 | Creation of novel inter- specific-interploid Hylocereus hybrids (Cactaceae) via embryo rescue显示文摘 | CISNEROS A GARCIA R B TEL-ZUR N | 2013 | Euphytica2013，189，3： | 1 |
| 14 | Association of interleukin-6 gene polymorphisms with bone mineral density in Mexican women显示文摘 | Magana JJ G o mez R Cisneros B etal | 2008 | J Hum Genet2008，39，6： | 1 |
| 15 | Multifractal hurst analysis of crude oil prices显示文摘 | Jose A R Cisneros M Carlos I V | 2002 | Physica A:Statistical Mechanics and Its Applications2002，313，34： | 1 |
| 16 | Proper differentiation of photoreceptors andamacrine cells depends on a regulatory loop between NeuroDand Six6显示文摘 | Conte I Marco-Ferreres R Beccari L Cisneros E Ruiz JM Tabanera al | 2010 | Development2010，137，14： | 1 |
| 17 | Symmetry/anti-symmetry phase transitions in crude oil markets显示文摘 | Jose A R Soriano A Cisneros M | 2003 | Physica A:Statistical Mechanics and Its Applications2003，322，： | 1 |
| 18 | Internal jugular vein valve incompetence is highly prevalent in transient global amnesia显示文摘 | Cejas C Cisneros LF Lagos R | 2010 | Stroke2010，41，： | 1 |
| 19 | Syn- thesis of novel highly reactive silicone - epoxy monomers for cationic photopolymerizations 显示文摘 | ORTIZ R A CISNEROS M L G GARCIA G A | 2005 | Polymer2005，46，10： | 1 |
| 20 | Toxic epidermal necrolysis-like cutaneous lupus erythematosus:A series of three patients显示文摘 | Cisneros CG Romiti R Santi CG | 2010 | Acta Derm Venereol2010，90，： | 1 |
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