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| 1 | The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy显示文摘γ δT 房间对感染和恶意的转变形成适应有免疫力的回答的重要部分。人的 γ 的分子的目标; δ大部分未知,却最近的 T 房间受体(TCR ) 遗体学习证实了 phosphorylated prenyl 代谢物的识别,在有 CD1 分子和细胞的应力的标记的建筑群的类脂化合物。所有这些分子是各种各样的癌症类型上的 upregulated,强调 γ 的潜在的重要性; δ在癌症 immunosurveillance 的 T 房间分隔空间并且为 γ 的使用铺平道路; δ在癌症治疗的 TCR。由 γ 的 Ligand 识别; δTCR 经常在 T 房间和目标 cells; 上要求 accessory/co-stimulatory 压力分子;这细胞的压力上下文因此提供一对有害自我反应保证不失灵。不同 α βT 房间, γ δ不管 HLA haplotype, T 房间认出他们的目标因此出现使可能性激动为现成,平底锅人口癌症免疫疗法。这里,我们在场人的 γ 的已知的 ligands 的评论; δT 房间并且讨论为癌症治疗利用这些房间的诺言。 | Mateusz Legut David K Cole Andrew K Sewell | 2015 | Cellular & Molecular Immunology2015，12，6： | 9 |
| 2 | CD8:Adhesion Molecule,Co-Receptor and Immuno-Modulator显示文摘CD8 is a cell surface glycoprotein found in cytotoxic T lymphocytes, which are important components in cellular immunity, esp. In the immune response to cancer and chronic infections. There are two forms of CD8,either as an αα homodimer or αβ heterodimer. It acts as an 'assistant' or co-receptor in the function of cytotoxic T cells where specific immunity is mediated by interaction of specific T cell receptor (αβTCR) and its ligand peptide major histocompatibility complex (pMHC). CD8 also binds to pMHC but away from the interface of pMHC and TCR contact, thereof no influence on the specificity of this interaction. If the TCR and CD8 bind to the same pMHC at the same time, CD8 is defined as a co-receptor, functioning through its signalling via its cytoplasmic tyrosine phosphorylation pathway; if CD8 binds to pMHC independently of the TCR, it is defined as an adhesion molecule. At present, the co-receptor function theory is dominated in the field.Recent study has also shown that murine CD8αα binds to TL antigen, an MHC homologue, therefore acts as an immuno-modulator. In this review, we discuss these current understandings of the three aspects of the CD8 functions and their structural basis. | David K Cole George F Gao | 2004 | Cellular & Molecular Immunology2004，1，2： | 4 |
| 3 | Laser capture microdissection: molecular analysis of tissue 显示文摘 | Bonner RF Emmert Buck MR Cole K | 1997 | Science1997，278，5342： | 1 |
| 4 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 5 | Good for the soul:The rela- tionship between work, wellbeing and psychological capital显示文摘 | Cole K Daly A Mak A | 2009 | The Journal of Socio- Economies2009，38，： | 1 |
| 6 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 7 | Peroxi- some proliferator-activated receptor gamma (PPAR gam- ma) and its ligands: a review 显示文摘 | HOUSEKNECHT K L COLE B M STEELE P J | 2002 | Domest Anim Endocri- nol2002，22，1： | 1 |
| 8 | Why the grass is not always greener: The competing effects of environmental regulations and factor intensities on US specialization'显示文摘 | COLE A ROBERT J SHIMAMOTO K | 2005 | Ecological Economics2005，，54： | 1 |
| 9 | A formulation for determining the single-pass mechanics of the continuous four-roll thin plate bending process 显示文摘 | HUA M COLE I M BAINESS K | 1997 | Journal of Materials Processing Technology1997，67，： | 1 |
| 10 | Anthracycline derivatives from a marine-derived New Zealand streptomycete 显示文摘 | Phipps R K Blunt J W Cole A L J | 2004 | ARKIVOC2004，，10： | 1 |
| 11 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 12 | Bending mechanicsms, experimental techniques and preliminary tests for the continuous four-roll plate bending process 显示文摘 | HUA M BAINESS K COLE I M | 1995 | Journal of Materials Processing Technology1995，48，： | 1 |
| 13 | Establishing a standard definition for child overweight and obesity worldwide: international survey 显示文摘 | Cole T J Bellizzi M C Flegal K M | 2003 | BMJ2003，320，： | 1 |
| 14 | Identification of the thymidine kinase gene of feline herpesvirus:use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs显示文摘 | Nunberg J H Wright D K Cole G E | 1989 | J Virol1989，63，8： | 1 |
| 15 | Sinc-sampled fiber Bragg gratings for identical multiple wavelength operation 显示文摘 | IBSEN M DURKIN M K COLE M J | 1998 | IEEE Photonics Tech Lett1998，10，6： | 1 |
| 16 | Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas,and selective toxicity against Apc mutant embryos显示文摘 | Jacoby RF Cole CE Tutsch K | 2000 | Cancer Res2000，60，7： | 1 |
| 17 | Biogeography of steam macroalgae in North American 显示文摘 | Sheath R G Cole K M | 1992 | Journal of Phycology1992，28，： | 1 |
| 18 | Characterisation of acid soluble collagen from skins of young and adult Nile perch(Lates niloticus)显示文摘 | MuyongaJH Cole C G B Duodu K G | | 0，，01： | 1 |
| 19 | Prevalence and persistence of sleep disordered breathing symptoms in young children:a 6-year population-based cohort study 显示文摘 | Bonuck K A Chervin R D Cole T J | | Sleep0，34，7： | 1 |
| 20 | Essential role of caveolae in interleukin-6 and insulin-like growth factor I-triggered Akt-1- mediated survival of multiple myeloma cells显示文摘 | Podar K Tai YT Cole CE | 2003 | J Biol Chem2003，278，8： | 1 |
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