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315篇 您的检索式：作者名="COLLINS L E"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘	Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A.	2009	中国神经肿瘤杂志2009，7，4：	3
3	Estrus synchronization and artificial insemination of hair sheep ewes in the tropics显示文摘	Godfrey R W Collins J R Hensley E L	1999	Theriogenology1999，51，：	1
4	The loss of species: mangrove extinction risk and geographic areas of global concern 显示文摘	POLIDORO B A CARPENTER K E COLLINS L	2010	PLoS ONE2010，，5：	1
5	Crop rotation and residue management effects on soil carbon and microbial dynamics 显示文摘	Collins H P Rasmussen P E Douglas C L	1992	Soil Science Society of America Journal1992，56，3：	1
6	Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women显示文摘	Barrett-Connor E Mosca L Collins P		0，，2：	1
7	Porcine sperm zona binding ability as an indicator of fertility显示文摘	COLLINS E D FLOWERS W L SHANKS R D	2008	Anim Re- prod Sci2008，104，1：	1
8	A three-phase sag generator fortesting industrial equipment显示文摘	Collins E R Morgan R L	1996	IEEE Transactions on Power Delivery1996，11，1：	1
9	Identification of attractive components of carob volatiles for the foreign grain beetle,Ahasverus advena(waltl)显示文摘	Wakefield M E Bryning G P Collins L E	2005	J stored prod res2005，41，：	1
10	Plant community response to loss of large herbivores : comparing consequences in a South African and a North American grassland显示文摘	Burns C E Collins S L Smith M D	2009	Biodiversity and Conservation2009，18，：	1
11	Use of composite fingerprints to determine the provenance of the contemporary sus-pended sediment load transported by rivers显示文摘	Collins A L Walling D E Leeks G J L	1998	Earth Surface Processes and Landforms1998，23，1：	1
12	Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis显示文摘	Devareddy L Hooshmand S Collins J K Lucas E A Chai S C Arjmandi B H	2008	The Journal of nutritional biochemistry2008，19，10：	1
13	查看详情显示文摘	Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th		0，，：	1
14	Steckel mill process optimization for production of X70 and X80 gas transmission linepipe显示文摘	Collins L E Bargar D L and Bowker	1995	Microalloying1995，，：	1
15	The l-Spy Insect Indicator: an effective trap h)r the detection of insect pests in empty stores and on fiat surfaces in the cereal and food trades显示文摘	Collins L E Chambers J	2003	Journal of Stored Prnduet Research2003，39，：	1
16	Affective Consequences of Social Comparison: Either Direction Has Its Ups and Downs 显示文摘	BUUNK B P COLLINS R L TAYLOR S E	1990	Journal of Personality and Social Psychology1990，59，6：	1
17	Efficacy of an in-activated vaccine for Prevention of repro- ductive failure induced by porcine reproductive and respiratory syndrome virus显示文摘	Plana Duran Collins J E Mengling W L	1997	Vet Microbiol1997，55，：	1
18	Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-l?beta throughout the 4-day estrous cycle of the rat显示文摘	Butcher R L Collins W E Fugo N W	1974	Endocrinology1974，94，：	1
19	Soil organic matter dynamics in corn-based agroecosystems of the central USA:Results from 13C natural abundance显示文摘	Collins H P Paul E A Blevens R L	1999	Soil Science Society of America Journal1999，63，：	1
20	B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels显示文摘	Christopher E Collins Amanda L Gavin Thi-Sau Migone	2006	Arthritis Res Ther2006，8，1：	1

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