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| 1 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 2 | Evalua- tion of egg and nauplii production parameters of a sin- gle stock of domesticated Penaeus monodon (giant tiger shrimp) across generations 显示文摘 | Coman G J Arnold S J Wood A T | 2013 | Aqua2013，，400401： | 1 |
| 3 | Benzylation of benzene with benzylalcoholonzeolitecatalysts显示文摘 | Candu N Florea M Coman S M | 2011 | AppliedCatalysisA: General2011，393，12： | 1 |
| 4 | Novel sol-gel synthesis for Bronsted and/or Lewis acidic MgF2-x ( OH ) x materials 显示文摘 | Wuttke S Coman S M Scholz G | 2008 | Chem Eur J2008，14，11： | 1 |
| 5 | Colorectal liver metastases : CT, MR imaging, and PET for diagnosis -meta - a- nalysis显示文摘 | Bipat S van Leeuwen MS Comans EF | 2005 | Radiology2005，237，1： | 1 |
| 6 | Longitudinal survey of lymphoeyte subpopulations in the first year of life显示文摘 | de Vfies E de Bruin - Versteeg S Comans - Bitter WM | 2000 | Pediatr Res2000，47，： | 1 |
| 7 | Novel sol-gel synthesis of acidic MgFx -x( OH )x Materials 显示文摘 | Wuttke S Coman S M Scholz G | 2008 | Chem Eur J2008，14，11： | 1 |
| 8 | Colorectal liver metastases: CT, MR imaging, and PET for diagnosis meta-analysis 显示文摘 | Bipat S van Leeuwen MS Comans EF | 2005 | Radiology2005，237，1： | 1 |
| 9 | Catalytic performance of nanoscopic, aluminium trifluoride based catalysts in the synthesis of( all- rac) - α- tocopherol 显示文摘 | Coman S M Wuttke S Vimont A | 2008 | Adv Synth Catal2008，350，： | 1 |
| 10 | Benzylation of benzene withbenzyl alcohol on zeolite catalysts显示文摘 | Candu N Florea M Coman S M | 2011 | Applied Catalysis A:Gener- a12011，393，1： | 1 |
| 11 | Colorectal liver metastases:CT,MR Imaging,and PET for diagnosis:Meta-analysis显示文摘 | Bipat S van Leeuwen MS Comans EFI | 2005 | Radiology2005，237，： | 1 |
| 12 | Tailor-made MgF2-based catalysts by sol-gel synthesis显示文摘 | Kenmitz E Wuttke S Coman S M | | 0，，31： | 1 |
| 13 | New heterogeneous catalysts for greener routes in the Synthesis of fine chemicals显示文摘 | Coman S M Pop G Stere C | 2007 | lournal of Catalysis2007，251，： | 1 |
| 14 | Longitudinal and transverse damage taxonomy in woven composite components显示文摘 | John S Herszberg I Coman F | 2001 | Composites Part B: Engineering2001，32，8： | 1 |
| 15 | Cyclisation of citroneUal over heterogeneous inorganic fluorides--highly chemo- and diastereoselective catalysts for (+)-isopulegol 显示文摘 | COMAN S M PATIL P WUTTKE S | 2009 | Chemistry Communication2009，，4： | 1 |
| 16 | Serological levels of apoptotic bodies, sFAS and TNF in lupus erythematosus 显示文摘 | Alecu M Coman G Alecu S | 2000 | Rom J Intern Med2000，3839，： | 1 |
| 17 | Transesterification of vegetable oils over Ca O catalysts显示文摘 | Verziu M Coman S M Richards R | 2011 | Catalysis Today2011，167，1： | 1 |
| 18 | Stable V/f con- trol system with controlled power factor angle for permanent magnet synchronous motor drives显示文摘 | AGARLITA S COMAN C ANDREESCU G | 2013 | IET Electric Power App- lications2013，7，4： | 1 |
| 19 | Cyclisation of citronellal over heterogeneous inorganic fluorides-highly chemo- and diastereoselective catalysts for (+)-isopulegol显示文摘 | Coman S M Patil P Wuttke S | 2009 | Chemistry Communication2009，，： | 1 |
| 20 | High - intensity, zero water- exchange production of juvenile tiger shrimp, Penaeus rnonodon: An evaluation of artificial substrates and stocking density显示文摘 | Arnold S J Coman F E Jackson C J | 2009 | Aquaculture2009，293，： | 1 |
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