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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 3 | 氮氧化物吸附催化器与选择性催化还原装置组合排放控制系统用的先进催化剂显示文摘与仅采用一种技术的系统相比,由氮氧化物(NO_x)吸附催化器(NAC)和选择性催化还原(SCR)装置组合的排放控制系统能够对稀燃条件下的NO_x控制提供更大的优势。然而,组合系统也对新的催化剂设计提出了挑战。与仅采用NAC的系统相比,NO_x再生时,NAC+SCR组合系统中NAC生成的氨(NH_3)是所需的特性。组合系统中的SCR需要与单独的SCR技术一样耐热,同时必须能抵抗上游的NAC周期性脱硫时出现的高温稀/浓状态反复变化。研究中,特别为组合系统研发了先进的NAC和SCR催化剂。改进的NAC催化剂展示出更宽广的运行温度窗口,并在减少铂族金属涂敷量的情况下获得了更高的NH_3生成活性。先进的SCR具有优异的低温NO_x还原效率,即便在高温稀/浓状态反复交替后依然具有极好的耐久性。采用改进的NAC和SCR催化剂后,系统性能显著提高。新研发的催化剂的优势也在车辆上得到了验证。 | Chen H Y Weigert E C Fedeyko J M Cox J P Andersen P J 许蕾 | 2012 | 国外内燃机2012，44，2： | 3 |
| 4 | Secure Spread Spectrum Watermarking for Multimedia显示文摘 | Cox I J Kilian J Leighton F T | | 0，，： | 3 |
| 5 | 用可调式涡轮增压技术降低排放并改善扭矩特性显示文摘目前,欧洲80%的轿车柴油机已采用涡轮增压。随着排放标准的日益严格,在不久的将来,涡轮增压机型有望接近100%。目前的一个主要热点是在高速柴油机上采用可调式涡轮增压技术(VGT)。在一台1.8L直喷式柴油机上做了大量的稳态试验研究,旨在对可调式涡轮增压发动机与配置带放气阀增压器的基准发动机进行比较,以观其潜在的益处。在欧洲试验循环中对排放产物十分重视的部分负荷工况下,分别控制可调增压器的叶片位置和废气再循环(EGR)阀的位置,以优化排放指标。在不牺牲固定式增压发动机的燃油耗、烟度的前提下,在一些间断工况点测得的NO_X减少到45%。在满足最高爆发压力、烟度和涡轮前温度限制条件下,可调增压发动机与装有固定增压基准发动机相比最大扭矩提高了10%。 | Hawley J G Wallace F J Cox A 栾敏 董复兴 | 2000 | 国外内燃机2000，，3： | 3 |
| 6 | Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease显示文摘长期地感染丙肝病毒的病人经常得长期的肝疾病,对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心,提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。 | Scott Grier Adrian KP Lim Nayna Patel Jeremy FL Cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 7 | Fulid infiltration and volume changes during mid-crustal mylonite of Proterozz granite, King Island, Tasmamia 显示文摘 | Streit J E Cox S F | 1998 | Journal of Metamorphic Geology1998，16，： | 2 |
| 8 | A theory of the term structure of interest rates显示文摘 | Cox J C Ingersoll J E Ross S A | 1985 | Econometrica1985，53，2： | 2 |
| 9 | Secure spread spectrum watermarking for multimedia显示文摘 | Cox I J Kilian J Leighton F T | 1997 | IEEE Trans on Image Processing1997，6，12： | 2 |
| 10 | Secure spread spectrum watermarking for multimedia显示文摘 | Cox I J Kilian J Leighton T Shamoon T | | 0，，： | 2 |
| 11 | 附睾和阔韧带乳头状囊腺瘤显示文摘乳头状囊腺瘤是一种罕见的上皮性肿瘤。发生在附睾头部和阔韧带,当病变为双侧时常伴VHL病。文献记载与转移性透明细胞肾细胞癌类似。由于肾细胞癌出现了新的相关标记,作者用CK7、RCC、PAX8、CA9和AMACR评估7例乳头状囊腺瘤免疫组化染色模式。 | Cox R Vang R Epstein J I 张仁亚 | 2014 | 临床与实验病理学杂志2014，30，6： | 2 |
| 12 | Secure spread spectrum watermarking for multimedia显示文摘 | Cox I J Kilian J Leighton F T | 1997 | IEEE Trans on Image Processing1997，6，12： | 2 |
| 13 | Secure spread spectrum watermarking for multimedia显示文摘 | COX I J KILLIAN J LEIGHTON T | | 0，，12： | 2 |
| 14 | Secure spread spectrum watermarking for multimedia显示文摘 | Cox I J Kilian J Leighton F T | 1997 | IEEE Trans on Image Processing1997，6，12： | 2 |
| 15 | Cecal carriage of Clostri-dinm perfringens in broiler chickens given mucosal starter culture 显示文摘 | Craven S E Stem N J Cox N A | 1999 | Avian Diseases1999，43，： | 1 |
| 16 | Co - treatment of H2 S and toluene in a biotrickling filter显示文摘 | Cox H H J A M Deshusses | 2001 | Chemical Engineering Journal2001，3901，： | 1 |
| 17 | The significance of natural and synthetic auxins in the control of stomatal movements 显示文摘 | Cox R C Snaith P J Mansfield TA | 1985 | Acta Horticulture1985，171，： | 1 |
| 18 | Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis 显示文摘 | Cao Z Kelly D J Cox A | 2000 | Kidney Int2000，58，6： | 1 |
| 19 | Detection of anti body to the foot-and-mouth disease virus (FMDV) non-structural polyprotein 3ABC in sheep by ELISA显示文摘 | Armstrong R M Cox S J Aggarwal N | 2005 | J Virol Meth2005，125，2： | 1 |
| 20 | Option Pricing:A Simplified Approach显示文摘 | Cox J Ross S Rubinstein M | 1979 | Journal of Financial Economics1979，7，： | 1 |
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