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| 1 | Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours worldwide.The mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related deaths.Systemic drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC treatment.Unfortunately,these therapies are ineffective in most cases due to late diagnosis and the development of tumour resistance.Thus,novel pharmacological alternatives are urgently needed.For instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune system.Furthermore,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC patients.In addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic alternatives.Here,we review the current and novel pharmacological approaches to fight HCC.Preclinical studies,as well as approved and ongoing clinical trials for liver cancer treatment,are discussed.The pharmacological opportunities analysed here should lead to significant improvement in HCC therapy. | Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M García-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho | 2023 | World Journal of Gastroenterology2023，29，17： | 2 |
| 2 | Reply to T Weishaar显示文摘 | DURAZO- ARVIZU R A CAMACHO P BOVET P | 2015 | Am J Clin Nutr2015，101，2： | 1 |
| 3 | MRI segmentation:methods and applications显示文摘 | Clarke L P Ve1thuizen M R P Camacho A | 1995 | Magnita Resonance Imaging1995，13，3： | 1 |
| 4 | Prediction rule for biogas valorisation in municipal solid waste landfill显示文摘 | Marticorena B Attal A Camacho P | 1993 | Water Sci Technol1993，27，2： | 1 |
| 5 | The origin of cor- relations in metabolomics data显示文摘 | Camacho D De La Fuente A Mendes P | 2005 | Metabolomics2005，1，1： | 1 |
| 6 | Analysis of clear corneal incision integrity in an ex vivo model 显示文摘 | May W Castro-Combs J Camacho W Wittmann P Behrens A | 2008 | J Cataract Refract Surg2008，34，6： | 1 |
| 7 | Measurement of intracellular calcium显示文摘 | Takahashi A Camacho P Lechleiter J D | 1999 | Physiol Rev1999，79，： | 1 |
| 8 | FTIR micro- scopic imaging of collagen and proteoglycan in bovine cartilage显示文摘 | Camacho N P West P Torzilli P A | 2001 | Biopolymers2001，62，1： | 1 |
| 9 | MRI segmentation: methods and applications显示文摘 | Clarke L P Velthuizen R P Camacho M A | 1995 | Magnetic Resonance Imaging1995，13，3： | 1 |
| 10 | Measurement of intracellular calcium 显示文摘 | Takahashi A Camacho P Lechleiter J D | 1999 | Physiol Rev1999，79，4： | 1 |
| 11 | Measurement of intracellular calcium显示文摘 | Takahashi A Camacho P Lechleiter JD | 1999 | Physiol Rev1999，79，4： | 1 |
| 12 | Prediction rule for biogas valorisation in municipal solid waste landfill显示文摘 | Marticorena B Attal A Camacho P | | 0，，02： | 1 |
| 13 | Prediction rules for biogas valorisation in municipal solid waste landfills显示文摘 | Marticorena B Attal A Camacho P | 1993 | Water Science & Technology1993，27，2： | 1 |
| 14 | Variation of fatty acid profile with solar cycle in outdoor chemostat culture of Isochrysis galbana ALII-4显示文摘 | Molina Grima E Sánchez Pérez J A García Camacho F | 1995 | J Appl Phycol1995，7，： | 1 |
| 15 | Experimental results for a microscale ethanol vapor jet ejector 显示文摘 | GARDNER W G JAWORSKI J W CAMACHO A P | 2010 | Journal of Micromechanies and Microengineering2010，20，45： | 1 |
| 16 | Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin显示文摘 | Azcárate IG Marín-García P Camacho N | 2013 | Br J Pharmacol2013，169，3： | 1 |
| 17 | Phylogenetic characterization of the epibiotic bacteria associated with the hydrothermal vent polychaete Alvinella pompejana显示文摘 | Haddad A Camacho F Durand P | | 0，，05： | 1 |
| 18 | Anaerobic digestion of municipal wastes in landfill 显示文摘 | Attal A Akunna J Camacho P | 1992 | Water Sci Tech1992，25，： | 1 |
| 19 | MRI segmentation: methods and applications 显示文摘 | Clarke L P Velthuizen R P Camacho M A | 1995 | Magnetic Resonance Imaging1995，13，3： | 1 |
| 20 | Prediction rules for biogas valorization in municipal solid waste landfills显示文摘 | Marticorena B Attal A Camacho P | 1993 | Water Science & Technology1993，27，3： | 1 |
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