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| 1 | The Yin-Yang of osteopontin in nervous system diseases: damage versus repair显示文摘Osteopontin is a broadly expressed pleiotropic protein,and is attracting increased attention because of its role in the pathophysiology of several inflammatory,degenerative,autoimmune,and oncologic diseases.In fact,in the last decade,several studies have shown that osteopontin contributes to tissue damage not only by recruiting harmful inflammatory cells to the site of lesion,but also increasing their survival.The detrimental role of osteopontin has been indeed well documented in the context of different neurological conditions(i.e.,multiple sclerosis,Parkinson’s,and Alzheimer’s diseases).Intriguingly,recent findings show that osteopontin is involved not only in promoting tissue damage(the Yin),but also in repair/regenerative mechanisms(the Yang),mostly triggered by the inflammatory response.These two apparently discordant roles are partly related to the presence of different functional domains in the osteopontin molecule,which are exposed after thrombin or metalloproteases cleavages.Such functional domains may in turn activate intracellular signaling pathways and mediate cell-cell and cell-matrix interactions.This review describes the current knowledge on the Yin and Yang features of osteopontin in nervous system diseases.Understanding the mechanisms behind the Yin/Yang would be relevant to develop highly specific tools targeting this multifunctional protein. | Giuseppe Cappellano Domizia Vecchio Luca Magistrelli Nausicaa Clemente Davide Raineri Camilla Barbero Mazzucca Eleonora Virgilio Umberto Dianzani Annalisa Chiocchetti Cristoforo Comi | 2021 | Neural Regeneration Research2021，16，6： | 2 |
| 2 | Recombinant environmental libraries provide access to microbial diversi- ty for drug discovery from natural products 显示文摘 | Courtois S Cappellano C M Ball M | 2003 | Applied and Environmental Microbiology2003，69，1： | 1 |
| 3 | Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products显示文摘 | Courtois S Cappellano C M Ball M | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 4 | Recombinantenvironmental libraries provide access to microbial diversity for drug discovery from natural products显示文摘 | Courtois S Cappellano C M Ball M | 2003 | Applied and Environmental Microbiology2003，69，1： | 1 |
| 5 | Modified expression of plasma glutathione peroxidase and manganese superoxide dismutase in human renal cell carcinoma 显示文摘 | Sarto C Frutiger S Cappellano F | 1999 | Electrophoresis1999，20，17： | 1 |
| 6 | Artificial chromosomes for antibiotic-producing actinomycetes显示文摘 | Sosio M Giusino F Cappellano C | 2000 | Nature Biotechnology2000，18，3： | 1 |
| 7 | Recombinant environmental libraries provide access to microbial diversi- ty for drug discovery from natural products 显示文摘 | Courtois S Cappellano C M Ball M | 2003 | Applied and Environmental Microbiology2003，69，1： | 1 |
| 8 | Modified expression of plasma glutathione peroxidase and manganese superoxide dismutase in human renal cell carcinoma 显示文摘 | Sarto C Frutiger S Cappellano F | 1999 | Electrophoresis1999，20，17： | 1 |
| 9 | Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study 显示文摘 | Da Silva NS Cappellano AM Diez B | 2010 | Pe- diatr Blood Cancer2010，54，3： | 1 |
| 10 | Recombinant environmental libraries provide access to microbial diver- sity for drug discovery from natural products显示文摘 | Courtois S Cappellano CM Ball M | 2003 | Applied and Environmental Microbiology2003，69，1： | 1 |
| 11 | Artificial chromosomes for antibiotic-producing actinomycetes显示文摘 | Sosio M Giusino F Cappellano C | 2000 | Nat Biotechnol2000，18，3： | 1 |
| 12 | Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products显示文摘 | Courtois S Cappellano C M Ball M | 2003 | Applied and Environment Microbiology2003，69，1： | 1 |
| 13 | Modified expression of plasma glutathione peroxidase and manganese superoxide dismutase in human renal cell carcinoma显示文摘 | Sarto C Frutiger S Cappellano F | 1999 | Electrophoresis1999，20，： | 1 |
| 14 | Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products显示文摘 | Courtois S Cappellano C M Ball M | 2003 | Appl Environ Mierobiol2003，69，1： | 1 |
| 15 | Different expression and function of the endocannabinoid system in human epicardial adipose tissue in relation to heart disease 显示文摘 | Cappellano G Uberti F Caimmi PP | 2013 | Can J Cardiol2013，29，4： | 1 |
| 16 | False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam显示文摘 | Viseoli C Maehetti M Cappellano P | 2004 | Clin Infect Dis2004，38，6： | 1 |
| 17 | Nutrition and Crohn' s disease: an update of print and Web-based guidance显示文摘 | Moorthy D Cappellano KL Rosenberg IH | 2008 | Nutr Rev2008，66，7： | 1 |
| 18 | Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products显示文摘 | COURTOIS S CAPPELLANO C M BALL M | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 19 | False-positive galactomannan Platelia aspergillus test results for patients receiving piperaeillin-tazobactam显示文摘 | Viscoli C Machetti M Cappellano P | 2004 | Clin Infect Dis2004，38，15： | 1 |
| 20 | Recombinant environmental libraries provide access to micro- bial diversity for drug discovery from natural products 显示文摘 | Courtois S Cappellano C M Ball M | 2003 | Appl Environ Mierobiol2003，69，1： | 1 |
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