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| 1 | Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation. | Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding | 2008 | World Journal of Gastroenterology2008，14，38： | 3 |
| 2 | Familiarity of physical and metabolic characteristic that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians显示文摘 | Sakul H Pratley R Cardon L | 1997 | Am J Hum Genet1997，60，： | 1 |
| 3 | Cellulose, hemicellulose and lignin slow steam pyrolysis: Thermal decomposition of biomass components mixtures显示文摘 | Giudicianni P Cardone G Ragucci R | 2013 | Journal of Analytical and Applied Pyrolysis2013，，100： | 1 |
| 4 | Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gamma delta T cells:role of CD86and inflammatory cytokines显示文摘 | Conti L Casetti R Cardone M Varano B Martino A Belardelli F Poccia F Gessani S | 2005 | J Immunol2005，174，1： | 1 |
| 5 | Vulvo-vaginal HPV infection: immunological aspects显示文摘 | Zarcone R Bellini P Cardone G | 1996 | Minerva Ginecol1996，48，3： | 1 |
| 6 | Genome-wide association studies for complex traits: consensus, uncertainty and challenges 显示文摘 | MCCARTHY M I ABECASIS G R CARDON L R | 2008 | Nat Rev Genet2008，9，： | 1 |
| 7 | Implementation and Testing of Passive Control Devices Based on Shape Memory Alloys 显示文摘 | Dolce M Cardone D Marnetto R | 2000 | Earthquake Engineering and Structural Dynamics2000，29，： | 1 |
| 8 | Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein 显示文摘 | Cardones A R Leitner W W Fang L | 2006 | Microvasc Res2006，71，1： | 1 |
| 9 | Genome-wide strategies for detecting multiple loci that influence complex diseases显示文摘 | Marchini J Donnelly P Cardon L R | 2005 | Nat Genet2005，37，4： | 1 |
| 10 | Implementation and tes- ting of passive control devices based on shape memory al- loys 显示文摘 | Dolce M Cardone D Marnetto R | 2000 | Earthquake Engineering and Structural Dyna- mics2000，29，： | 1 |
| 11 | Using haplotype blocks to map human complex trait loci显示文摘 | Cardon L R | 2003 | Trends Genet2003，19，3： | 1 |
| 12 | Implementation and testing of passive control devices based on shape memory alloys 显示文摘 | Dolce M Cardone D Mametto R | 2000 | Earthquake engineering and structuraldynamics2000，29，： | 1 |
| 13 | Misfortunes or Mistakes? Cultural Sensemaking of Entrepreneurial Failure 显示文摘 | CARDON M S STEVENS C E POTTER D R | 2011 | Journal of Business Venturing2011，26，1： | 1 |
| 14 | VEGF inhibitors in cancer therapy 显示文摘 | CARDONES A R BANEZ L L | 2006 | Curr Pharm Des2006，12，3： | 1 |
| 15 | Spermatogenesis,epididymis morphology and plasma sex steroid secre-tion in the male lizard Podarcis sicula e?q)Osed to diuron显示文摘 | Cardone A Comitato R Angelini F | 2008 | Environmental Research2008，108，2： | 1 |
| 16 | Reciprocal acti- vating interaction between dendritic cells and pamidr- onate-stimulated gammade!ta T cells; role of CD8fi and inflammatory cytokines显示文摘 | Conti L Casetti R Cardone M | 2005 | J Immunol2005，174，1： | 1 |
| 17 | Regulation of cell death protease Caspase-9 by phosphorylation显示文摘 | CARDONE M H ROY N STENNICKE H R | 1998 | Science1998，282，5392： | 1 |
| 18 | Vulvo-vaginal HPV infection:immunological aspects显示文摘 | Zarcone R Bellini Cardone G | 1996 | Minerva Ginecol1996，48，3： | 1 |
| 19 | A general test of association for quantitative traits in nuclear families显示文摘 | Abecasis G R Cardon L R Cookson W O | 2000 | Am J Hum Genet2000，66，： | 1 |
| 20 | Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments 显示文摘 | Carmelli D Cardon LR Fabsitz R | 1994 | Am J Hum Genet1994，55，3： | 1 |
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