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| 1 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 2 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 3 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，： | 2 |
| 4 | Singular and non-singular approaches for predicting fatigue crack growth be- havior显示文摘 | Castro J T P Meggiolaro M A Miranda A C O | 2005 | International Journal of Fatigue2005，27，： | 1 |
| 5 | New oxidation catalysts based on iron(III) porphyrins immobilized on Mg-Al layered double hydroxides modified with triethanolamine 显示文摘 | CASTRO K A D F BAIL A GROSZEWICZ P B MACHADO G S SCHREINER W H WYPYCH F NAKAGAKI S | 2010 | Appl Catal A: Gen2010，386，： | 1 |
| 6 | The flow around a surface-mounted cube in uniform and turbulent streams显示文摘 | CASTRO I P ROBINS A G | 1977 | J Fluid Mech1977，79，2： | 1 |
| 7 | Scribe: a large-scale and decentralized application-level multicast infrastructure显示文摘 | CASTRO M DRUSHEL P KERMARREC A M | 2002 | Selected Areas in Communications2002，20，8： | 1 |
| 8 | Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives 显示文摘 | Gordaliza M Garcia P A Castro M A | 2004 | Toxicon2004，44，4： | 1 |
| 9 | Updated guidelines for using interferon gamma release assays to detect Mycobacterium turculosis infectiorUnited States, 2010 显示文摘 | Mazurek GH Jereb J Vernon A LoBue P Goldberg S Castro K IGRA Expert Committee Centers for Disease Control and Prevention (CDC) | 2010 | MMWR Recomm Rep2010，59，5： | 1 |
| 10 | Existence and uniqueness for a variational hyperbolic system without resonance显示文摘 | | 1980 | Nonlinear Analysis1980，4，： | 1 |
| 11 | Opticalparametric oscillator-based hotoacoustio detection ofhydrogen cyanide for biomedical applications 显示文摘 | Arslanov D D Castro M P Creemers N A | 2013 | J BiomedOpt2013，18，10： | 1 |
| 12 | Linezolid treatment of ventriculoperitoneal shunt infection without implant removal显示文摘 | Castro P Soriano A Escrich C | 2005 | Eur J Clin Microbiol Infect Dis2005，24，9： | 1 |
| 13 | An improved RTN continuous-time formulation for the short-term scheduling of multipurpose batch plants 显示文摘 | CASTRO P BARBOSA-Povoa A P F D MATOS H | 2001 | Industrial and Engineering Chemistry Research2001，40，9： | 1 |
| 14 | Concurrent and Simple Digital Controller of an AC/DC Converter with Power Factor Correction Based on an FPGA显示文摘 | De Castro A Zumel P Garcia O | 2003 | IEEE Trans on Power Electronics2003，18，1： | 1 |
| 15 | Correlation between valsalva leak point pressure and maximal urethral closure pressure in women with stress urinary incontinence 显示文摘 | Feldner P C Jr Bezerra L R de Castro R A | 2004 | Int Urogynecol J Pelvic Floor Dysfunct2004，15，3： | 1 |
| 16 | Parameterized fast deeoupled power flow methods for obtaining the maximum loading point of power systems Part Ⅰ and Part Ⅱ显示文摘 | Alves D A Da Silva L C P Castro C A | 2004 | Electric Power Systems Research2004，69，： | 1 |
| 17 | Astringency removal of ' Giombo' persimmon fruits submitted to different temperatures 显示文摘 | Antoniolli L R De Camargo e Castro P R Kluge R A | 2002 | Pesquisa Agropecuaria Brasileira2002，37，5： | 1 |
| 18 | An improved multiaxial rainflow algorithm for non-proportional stress or strain histories Part II: The Modified Wang- Brown method 显示文摘 | Meggiolaro M A De Castro J T P | 2012 | International Journal of Fatigue2012，42，： | 1 |
| 19 | Rapid separation of free fatty acids in vegetable oils by capillary electrophoresis 显示文摘 | Castro C Barra P M D C Oliveira M A L D | 2014 | Phytochemical Analysis2014，25，3： | 1 |
| 20 | A faulttolerant architectural approach for dependable systems显示文摘 | de Lemos R de Castro P A G Rubira C M | 2006 | IEEE Software2006，23，2： | 1 |
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