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| 1 | Predicting early outcomes of liver transplantation in young children: The EARLY study显示文摘AIM To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years.METHODS This study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June 2015.Pre-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form. Associations between potential predictor variables and outcomes were determined using univariate and multiple logistic [odds ratio(OR); 95%CI] or linear(effect size, ES; 95%CI) regressions. RESULTS There were 65 children, of mean age 11.9(SD 7.1) mo and weight 8.5(2.1) kg, with biliary-atresia in 40(62%), who had a living related donor [LRD; 29(45%)], split/reduced [21(32%)] or whole liver graft [15(23%)]. Outcomes after liver transplant included: ventilator-days of 12.5(14.1); pediatric intensive care unit mortality of 5(8%); re-operation in 33(51%), hepatic artery thrombosis(HAT) in 12(19%), portal vein thrombosis(PVT) in 11(17%), and any severe complication(HAT, PVT, bile leak, bowel perforation, intraabdominal infection, retransplant, or death) in 32(49%) patients. Predictors of the prespecified primary outcomes on multiple regression were:(1) HAT: split/reduced(OR 0.06; 0.01, 0.76; P = 0.030) or LRD(OR 0.16; 0.03, 0.95; P = 0.044) vs whole liver graft; and(2) ventilator-days: surgeon(P < 0.05), lowest antithrombin(AT) postoperative day 2-5(ES-0.24;-0.47,-0.02; P = 0.034), and split/reduced(ES-12.5;-21.8,-3.2; P = 0.009) vs whole-liver graft. Predictors of the pre-specified secondary outcomes on multiple regression were:(1) any thrombosis: LRD(OR 0.10; 0.01, 0.71; P = 0.021) or split/reduced(OR 0.10; 0.01, 0.85; P = 0.034) vs whole liver graft, and lowest AT postoperative day 2-5(OR 0.93; 0.87, 0.99; P = 0.038); and(2) any severe complication: surgeon(P < 0.05), lowest AT postoperative day 2-5(OR 0.92; 0.86-0.98; P = 0.016), and split/reduced(OR 0.06; 0.01, 0.78; P = 0.032) vs whole-liver graft. CONCLUSION In young children, whole liver graft and surgeon was associated with more complications, and higher AT postoperative day 2-5 was associated with fewer complications early after liver transplantation. | Rashid Alobaidi Natalie Anton Dominic Cave Elham Khodayari Moez Ari R Joffe | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | The Imperfect Market For Technology Licenses显示文摘 | Caves R E | 1983 | Oxford Bulletin of Economics and Statistics1983，，： | 1 |
| 3 | Randomized trial of endoscopic stenting versus surgical bypass in malignant low bileduct obstruction显示文摘 | Mitty R Cave DR | 1995 | Cast ro intest Endosc1995，42，3： | 1 |
| 4 | Causes of direct investment: Foreign firms'shares in Canadian and United Kingdom manufacturing industries显示文摘 | Caves R E | 1974 | The Review of Economics and Statistics1974，56，3： | 1 |
| 5 | From entry barriers to mobility barriers 显示文摘 | Caves R E Porter M E | 1977 | Quarterly Journal of Economics1977，91，2： | 1 |
| 6 | The Economic Theory of Index Numbers and the Measurement of Input, Output, and Productivity 显示文摘 | Caves D W Christensen L R Diewert W E | 1982 | Econometric1982，50，6： | 1 |
| 7 | Multinational firms, competition and productivity in host - country markets 显示文摘 | CAVES R E | 1974 | Economics1974，41，162： | 1 |
| 8 | Multinational Firms,Competition and Productivity in Host Country Market显示文摘 | CAVES R E | 1974 | Economica1974，41，162： | 1 |
| 9 | Australian aviation safety --observations from the 'luck' country显示文摘 | Braithwrite G R Caves R E Faulkner J P E | 1999 | International Journal of Aviation Psychology1999，9，4： | 1 |
| 10 | The Economic Theory of Index Numbers and the Measurement of Input, Output, and Productivity显示文摘 | Caves D W Christensen L R Diewert W E | 1982 | Econometrica1982，50，6： | 1 |
| 11 | The economic theory of in- dex numbers and the measurement of input, output, and produc- tivity 显示文摘 | Caves L R Christensen W E Diewert | 1982 | Journal of Econometrica1982，，6： | 1 |
| 12 | Methodology for predicting European short-haul air transport demand from regional airports显示文摘 | Brooke A S Caves R E Pitfield D E | 1994 | Journal of Air Transport Management1994，1，1： | 1 |
| 13 | The Economic Theory of Index Numbers and Measurement of Input,Output and Productivity显示文摘 | Chrestensen L R Diewart W E | 1982 | Econometrica1982，50，6： | 1 |
| 14 | The Economic Theory of Index Nunrbers and the Measurement of Input, Output and Produc tivity显示文摘 | Caves D W Christensen L R DiewertW E | 1982 | Econometrica1982，，5： | 1 |
| 15 | International corporation: the industrial economics of foreign investment显示文摘 | CAVES R E | 1971 | Economica1971，38，1： | 1 |
| 16 | Contracts between art and commerce显示文摘 | Caves R E | 2003 | Journal of EconomicPerspectives2003，17，2： | 1 |
| 17 | Multonational Firms,Competition and Productively in Host Country Market显示文摘 | | 1974 | Economica1974，41，： | 1 |
| 18 | Productivity in US Railroads: 1951 - 1974显示文摘 | Caves D W L R Christensen and J A Swanson | 1980 | Bell Journal of Economics1980，，： | 1 |
| 19 | Mul- tilateral Compositions of Output, Input and Productivity U sing Superlative Index Numbers显示文摘 | CAVES D W CHRISTENSEN L R DIEWERT W E | 1982 | Economic Journal1982，，8： | 1 |
| 20 | Synergy,agency and the determinants of premia paid in mergers显示文摘 | SLUSKY A CAVES R E | 1991 | Journal of Industrial Economics1991，39，3： | 1 |
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