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178篇 您的检索式：作者名="Cayrol"

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	题名	作者	年代	出处	被引量
1	αV integrin:A new gastrin target in human pancreatic cancer cells显示文摘AIM:To analyse αV integrin expression induced by gas-trin in pancreatic cancer models. METHODS:αV integrin mRNA expression in human pan-creatic cancer cells was analysed using a 'cancer genes' array and confirmed by real-time reverse transcription-polymerase chain reaction (PCR). Western blotting and semi-quantitative immunohistochemistry were used to examine protein levels in human pancreatic cancer cell lines and pancreatic tissues, respectively. The role of αV integrin on gastrin-induced cell adhesion was examined using blocking anti-αV integrin monoclonal antibodies. Adherent cells were quantified by staining with crystal violet.RESULTS: Using a 'cancer genes' array we identified αV integrin as a new gastrin target gene in human pancreatic cancer cells. A quantitative real-time PCR approach was used to confirm αV integrin gene expression. We also demonstrate that Src family kinases and the PI 3-kinase, two signalling pathways specifically activated by the CCK-2 receptor (CCK2R), are involved in gastrin-mediated αV integrin expression. In contrast, inhibition of the ERK pathway was without any effect on αV integrin expression induced by gastrin. Our results also show that gastrin modulates cell adhesion via α V integrins. Indeed, in vitro adhesion assays performed on fibronectin show that gastrin significantly increases adhesion of pancreatic cancer cells. The use of blocking anti-αV integrin monoclonal antibodies completely reversed the increase in cell-substrate adhesion induced by gastrin. In addition, we showed in vivo that the targeted CCK2R expression in the pancreas of Elas-CCK2 mice, leads to the overexpression of αV integrin. This process may contribute to pancreatic tumour development observed in these transgenic animals. CONCLUSION:αV integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion.	Celine Cayrol Claudine Bertrand Aline Kowalski-Chauvel Laurence Daulhac Elizabeth Cohen-Jonathan-Moyal Audrey Ferrand Catherine Seva	2011	World Journal of Gastroenterology2011，17，40：	4
2	Proteomic composition of the acrostyle" Novel approaches to identify cuticular proteins involved in virus-insect interactions显示文摘	Craig Graham Webster Maelle Thillier Elodie Pirolles Bastien Cayrol Stephane Blanc Marilyne Uzest	2017	Insect Science2017，24，6：	3
3	Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty显示文摘	Grados F Depriester C Cayrolle G et a1		0，，12：	1
4	Long - term obser- vations of vertebral osteopomtic fractures treated by percutaneous vertebmplasty显示文摘	Grados F Depriester C Cayrolle G	2000	Rheumatology2000，39，12：	1
5	Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica显示文摘	Saikali P Cayrol R Vincent T	2009	Autoimmun Rev2009，92，2：	1
6	The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1显示文摘	Cayrol C Girard JP	2009	Proc Natl Aead Sci U S A2009，106，22：	1
7	Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty显示文摘	Grados F Depriester C Cayrolle G	2000	Rheumatology2000，39，：	1
8	A reasoning model based on the production of acceptable arguments显示文摘	Amgoud L Cayrol C	2002	Annals of Mathematics and Artificial Intelligence2002，34，：	1
9	Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty显示文摘	Grados F Depriester C Cayrolle G	2000	Rheumatology(Oxford)2000，39，12：	1
10	Effector functions of antiaquaporin-4 autoantibodies in neuromyelitis optica显示文摘	Cayrol R Saikali P Vincent T	2009	Ann N Y Acad Sci2009，1173，：	1
11	Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty显示文摘	Grados F Depriester C Cayrolle G	2009	SAS J2009，3，3：	1
12	Anti -aquaporin -4 auto -antibodies orchestrate the pathogenesis in neuromyelitis optica 显示文摘	SAIKALI P CAYROL R VINCENT T	2009	Autoim- mun Rev2009，9，2：	1
13	Functional consequences of neuromyelitis optica-IgG astrocyte interactions on bloodbrain barrier permeability and granulocyte recruitment 显示文摘	Vincent T Saikali P Cayrol R	2008	Immunol2008，181，8：	1
14	Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty显示文摘	Grados F Depriester C Cayrolle G	2000	Rheumatology (Oxford)2000，39，12：	1
15	Functional consequences of neuromyelitis optica - IgG astrocyte interactions on blood - brain barrier permeability and granulocyte recruitment显示文摘	VINCENT T SAIKALI P CAYROL R	2008	J Immunol2008，181，8：	1
16	Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty显示文摘	Grados F Depriester C Cayrolle G	2000	Rheumatology (Oxford)2000，39，12：	1
17	Long-term observations of vertebral osteoporotic fractures treated by pereutaneous vertebroplasty显示文摘	Grados F Depriester C Cayrolle G	2010	Rheumatology (Oxford)2010，39，12：	1
18	Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty 显示文摘	Grados F Depriester C Cayrolle G	2000	Rheumatology ( Oxford)2000，39，：	1
19	Study of the nematopha- gous fungus Paecilomyces lilacinus 显示文摘	Cayrol J C Dijan C Pijarowski L	1989	Revue de Nematolo- gie1989，12，4：	1
20	lxmg term observation of vertebral osteoporotic fracture streated by percutaneous vertebroplasty 显示文摘	Grados F Depriester C Cayrolle G	2000	Rheumatology ( Oxford)2000，39，12：	1

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