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| 1 | Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice显示文摘AIM To evaluate antihepatoma effect ofantisense phosphorothioate oligodeo-xyribonucleotides (S-ODNs) targeted to alpha-fetoprotein (AFP) genes in vitro and in nudemice.METHODS AFP gene expression was examinedby immunocytochemical method or enzyme-linked immunosorbent assay. Effect of S-ODNson SMMC-7721 human hepatoma cell growth invitro was determined using microculturetetrazolium assay. In vivo antitumor activitiesof S-ODNs were monitored by measuring tumorweight differences in treated and control micebearing SMMC-7721 xenografts. Induction of cellapoptosis was evaluated by fluorescence-activated cell sorter (FACS) analysis.RESULTS Antisense S-ODN treatment led toreduced AFP gene expression. Specificantisense S-ODNs, but not control S-ODNs,inhibited the growth of heaptoma cells in vitro.In vivo. only antisense S-ODNs exhibitedobvious antitumor activities. FACS analysisrevealed that the growth inhibition by antisenseS. ODNs was associated with their cell apoptosisinduction.CONCLUSION Antisense S-ODNs targeted toAFP genes inhibit the growth of human hepatomacells and solid hepatoma, which is related totheir cell apoptosis induction. | Xing Wang Wang~1 Jin Hui Yuan~1 Ru Gang Zhang~1 Li Xia Guo~1 Yong Xie~2 Hong Xie~1 ~1Department of Biotherapy,Shanghai Institute of Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China ~2Department of Biology,Hong Kong University of Science and Technology,ChinaDr.Xing Wang Wang earned Ph.D.from Shanghai Institute of Materia Medical,Chinese Academy of Sciences in 1997.Now a professor at Shanghai Institute of Cell Biology,Chinese Academy of Sciences. | 2001 | World Journal of Gastroenterology2001，7，3： | 21 |
| 2 | Posterior gut development in Drosophila:a model system for identifying genes controlling epithelial morphogenesis显示文摘The posterior gut of the Drosophila embryo, consisting of hindgut and Malpighian tubules, provides a simple,well-defined system where it is possible to use a genetic approach to define components essential for epithelial morphogenesis.We review here the advantages of Drosophila as a model genetic organism, the morphogenesis of the epithelial structures of the posterior gut, and what is known about the genetic requirements to form these structures.In overview, primordia are patterned by expression of hierarchies of transcription factors; this leads to localized expression of cell signaling molecules, and finally, to the least understood step: modulation of cell adhesion and cell shape. We describe approaches to identify additional genes that are required for morphogenesis of these simple epithelia, particularly those that might play a structural role by affecting cell adhesion and cell shape. | LENGYEL JUDITH A XUE JUN LIU (Department of Molecular, Cell and Developmental Biology University of California at Los Angeles, Los Angeles, CA USA, 90095-1606 USA) | 1998 | Cell Research1998，8，4： | 5 |
| 3 | syndromes显示文摘 | Quilici j Banzet N Paule P Circulating endothelial cell count as a diagnostic marker for non-ST-elevation acute coronary | 2004 | Circulation2004，110，10： | 1 |
| 4 | using elicitation and precursor 显示文摘 | Shinde A N Malpathak N Fulzele D E Optimized production of isoflavones in cell cultures of Psoralea corylifolia L | 2009 | Feeding BiotechnolBioproc Eng2009，14，： | 1 |
| 5 | Interna- tional Germ Cell Cancer Collaborative Group显示文摘 | International Germ Cell Consensus Classification: a prognostic fac- tor-based staging system for metastatic germ cell cancers | 1997 | J Clin Oncol1997，15，2： | 1 |
| 6 | A retrospective muhicenter study 显示文摘 | Fassas A A Passweg J R Anagnostopoulos transplantation Hematopoietic stem cell for multiple sclerosis | 2002 | J Neurol2002，249，8： | 1 |
| 7 | Activation-induced cell death vs passive macrophage-dependent deletion 显示文摘 | Gonzalo JA Baixeras E Gonzalez-Garcia A Differential in vivo effects of a superantigen and an antibody targeted to the same T cell receptor | 1994 | J Immunol1994，152，： | 1 |
| 8 | strain TC 20 in a fed-batch system using glycerol to produce feedstock for biodiesel and Omega-3 oils显示文摘 | Lee CK Dumsday G Nichols PD et aLHigh cell density cultivation of a novel Aurantiochytrium sp | 2013 | Appl Microbiol Bio- technol2013，97，15： | 1 |
| 9 | but not in cell cultures of Centaurium erythraea RAFN 显示文摘 | Abd E1-Mawla A M Schmidt W Beerhues L Cinnamic acid is a precursor of benzoic acids in cell cultures of Hype-ricum and rosaemum L | 2001 | Planta2001，，212： | 1 |
| 10 | Non small Cell Lung Cancer Collaborative Group 显示文摘 | Chemotherapy in non-small cell lung cancer= a meta-analysis u- sing updated data on individual patients from 52 randomised clinical trials | 1995 | BMJ1995，311，7010： | 1 |
| 11 | 显示文摘 | Paul P Cabestre FA Ibrahim EC :Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of the HLA-G mRNA and expression of soluble HLA-G5 HLA-G6 and-G7 transcripts in human transfected cells | 2000 | Hum Immunol2000，61，11： | 1 |
| 12 | Tumorigenic line by human polymorphonuclear leukocytes activated by lipopolysaccharide 显示文摘 | Tamatani T Turk P Weitzman S Oyasu R conversion of a rat urothelial cell | 1999 | Jpn J CancerRes1999，90，8： | 1 |
| 13 | Role of geranylgeranylation and Rho proteins显示文摘 | Essig M Nguyen G Prie D et aL 3-Hydroxy-3-methyl glutaryl coenzyme A reductase inhibittors increase fibrinolytic activity in rat aorticendothelial cell s | 1998 | Circ Res1998，83，7： | 1 |
| 14 | Community-acquired pneumonia in the elderly: Spanish muhicentre study显示文摘 | Zalacain R Tones A Cells R | 2003 | Eur Respir J2003，21，2： | 1 |
| 15 | Intrinsic material properties of the erythrocyte membrane indicated by mechanical analysis of deformation显示文摘 | Evans E A La Celle P L | 1975 | Blood1975，，45： | 1 |
| 16 | 显示文摘 | Li X Jiang B Pan B: Biotranstbrmation of phenylpyruvic acid to phenyllactic acid by growing and resting cells of a Lactobacillus sp | 2007 | Biotechnol Lett2007，29，： | 1 |
| 17 | The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity显示文摘 | CELl F S SHULDINER A R | 2002 | Curr Diab Rep2002，2，2： | 1 |
| 18 | II:Theca cell inhibition of bovine oocyte maturation in vitro显示文摘 | Richard F J Sirard M A Effects of follicular cells on oocyte maturation | 1996 | Biol Reprod1996，54，1： | 1 |
| 19 | Clin Genitourin Cancer显示文摘 | Goodman OB Jr Symanowski JT Loudyi A Circulating tumor cells as a predictive biomarker in patients with hormone-sensitive prostate cancer | 2011 | 9( 1 ) :31-382011，9，1： | 1 |
| 20 | with soybean meal-induced enteritis显示文摘 | Bakke-McKeUep A M Press C M Baeverfjord G et aLChanges in im- mune and enzyme histochemical phenotypes of cells in the intestinal mucosa of Atlantic salmon Sa/mo sa/ar L | 2000 | J Fish Dis2000，23，： | 1 |
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