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| 1 | Gastroesophageal reflux disease: Important considerations for the older patients显示文摘Gastroesophageal reflux disease (GERD) is the most common upper gastrointestinal disorder seen in the elderly. The worldwide incidence of GERD is increasing as the incidence of Helicobacter pylori is decreasing. Although elderly patients with GERD have fewer symptoms, their disease is more often severe. They have more esophageal and extraesophageal complications that may be potentially life threatening. Esophageal complications include erosive esophagitis, esophageal stricture, Barrett's esophagus and adenocarcinoma of the esophagus. Extraesophageal complications include atypical chest pain that can simulate angina pectoris; ear, nose, and throat manifestations such as globus sensation, laryngitis, and dental problems; pulmonary problems such as chronic cough, asthma, and pulmonary aspiration. A more aggressive approach may be warranted in the elderly patient, because of the higher incidence of severe complications. Although the evaluation and management of GERD are generally the same in elderly patients as for all adults, there are specific issues of causation, evaluation and treatment that must be considered when dealing with the elderly. | Maxwell M Chait | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，12： | 22 |
| 2 | Lower gastrointestinal bleeding in the elderly显示文摘Lower gastrointestinal bleeding(LGIB) is an important worldwide cause of morbidity and mortality in the elderly.The incidence of LGIB increases with age and corresponds to the increased incidence of specific gastrointestinal diseases that have worldwide regional variation,co-morbid diseases and polypharmacy.The evaluation and treatment of patients is adjusted to the rate and severity of hemorrhage and the clinical status of the patient and may be complicated by the presence of visual,auditory and cognitive impairment due to age and co-morbid disease.Bleeding may be chronic and mild or severe and life threatening,requiring endoscopic,radiologic or surgical intervention.Colonoscopy provides the best method for evaluation and treatment of patients with LGIB.There will be a successful outcome of LGIB in the majority of elderly patients with appropriate evaluation and management. | Maxwell M Chait | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，5： | 3 |
| 3 | A natural modal expansion for the flexible robot arm problem via a self-adjoint formulation显示文摘 | Chait Y Mik(l)avc(I)c M Maccluer C R | 1990 | IEEE Transaction on Robotics and Automation1990，6，5： | 1 |
| 4 | Prevention Conference Ⅵ: Diabetes and Cardiovascular Disease: Writing Group Ⅱ:pathogenesis of atherosclerosis in diabetes显示文摘 | Eckel RH Wassef M Chait A | 2002 | Circulation2002，105，18： | 1 |
| 5 | Prevention conference Ⅵ: diabetes and cardiovascular disease writing group Ⅱ : pathogenesis of atherosclerosis in diabetes 显示文摘 | Eckel RH Wassef M Chait A | 2002 | Circulation2002，105，18： | 1 |
| 6 | Prevention confer enee VI:diabetes and cardieascular disease writing group II pathogenesis of atherosccerosis in diabetes cireulation显示文摘 | Eekel RH Wassefun M Chait A | 2002 | Circulation2002，105，： | 1 |
| 7 | Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages显示文摘 | Kusuhara M Chait A Cader A | | 0，，： | 1 |
| 8 | A practical ion trap mass spectrometer for the analysis of peptides by matrix-assisted laser desorption/ionization显示文摘 | QIN J STEENVOORDEN R J J M CHAIT B T | 1996 | Anal Chem1996，68，： | 1 |
| 9 | Central venous linerelated thrombosis in cllildren:association with central venous line loeation and insertion technique显示文摘 | Male C Chait P Andrew M | 2003 | Blood2003，101，11： | 1 |
| 10 | Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent faetors 显示文摘 | Denninger M H Chait Y Casadevall N | 2000 | Hepatology2000，31，3： | 1 |
| 11 | Influence of arm movement on central tip location of periph- erally inserted central catheters (PICCs)显示文摘 | Connolly B Amaral J Walsh S Temple M Chait P Stephen D | 2006 | Pediatr Radiol2006，36，： | 1 |
| 12 | Prevention Conference VI:Diabetes and Cardiovascular Disease:Writing Group II:Pathogenesis of atherosclerosis in diabetes显示文摘 | Eckel RH Wassef M Chait A | 2002 | Circulation2002，105，18： | 1 |
| 13 | A natural modal expansion for the flexible robot arm problem via a self-adjoint formulation显示文摘 | Chait Y Miklavcic M Maccluer C R Radcliffe C J | 1990 | IEEE Transactions on Robotics and Automation1990，6，5： | 1 |
| 14 | Apractical ion trap mass spectrometer for the analysis of peptides by matrix assisted laser desorption/ionization显示文摘 | Qin J Steenvoorden R J J M Chait B T | 1996 | Anal Chem1996，68，10： | 1 |
| 15 | Central venous line-related thrombosis in children : association with central venous line location and insertion technique显示文摘 | Male C Chait P Andrew M | 2003 | Blood2003，101，： | 1 |
| 16 | Prevention conference Ⅳ: Diabetes and Cardiovascular Disease: Writing Group Ⅱ: Pathogenesis of atherosclerosis in diabetes 显示文摘 | Eckel RH Wassef M Chait A | 2002 | Circulation2002，105，18： | 1 |
| 17 | Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small dense low density lipoproteins显示文摘 | Tribble DL Rizzo M Chait A | 2001 | Am J Med2001，110，2： | 1 |
| 18 | Inhibition of hypercholesterolemia induce atherosclerosis in the nonhuman promate by probucol显示文摘 | Raines EW Chait A | 1994 | J Clin Invest1994，94，： | 1 |
| 19 | Disturbance rejection in flexible struc-tures via quantitative feedback theory显示文摘 | CHAIT Y PARK M | 1993 | AIAA Journal of Guidance Control and Dynamics1993，16，5： | 1 |
| 20 | Pathophysio-logical concentrations of glucose promote oxidativemodification of low density lipoprotein by a super-oxide-dependent pathway显示文摘 | Kawamura M Heinecke J W Chait A | 1994 | The Journal of Clini-cal Investigation1994，94，77： | 1 |
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