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| 1 | New-found link between microbiota and obesity显示文摘Due to the grave pathological role of obesity, worldwide research is being continued to find out the causative factors involved in it. Recent advances in this field reveal a possible relationship between the compositional pattern of gut microbiota and genesis of obesity. Several study results have shown that short-chain fatty acids(SCFAs, microbiota-induced fermentation products) and lipopolysaccharides(LPS, an integral component of Gram negative microorganisms) play the key role in linking the two. Though several SCFAs are produced as microbiota-fermentation products, three of them, i.e., butyrate, propionate and acetate have been found to be definitely involved in obesity; though individually they are neither purely obesogenic nor antiobesogenic. Out of these, butyrate and propionate are predominantly antiobesogenic. Butyrate, though a major energy source for colonocytes, has been found to increase mitochondrial activity, prevent metabolic endotoxemia, improve insulin sensitivity, possess antiinflammatory potential, increase intestinal barrier function and protect against diet-induced obesity without causing hypophagia. Propionate has been found to inhibit cholesterol synthesis, thereby antagonizing the cholesterol increasing action of acetate, and to inhibit the expression of resistin in adipocytes. Moreover, both these SCFAs have been found to cause weight regulation through their stimulatory effect on anorexigenic gut hormones and to increase the synthesis of leptin. Unlike butyrate and propionate, acetate, which is substantially absorbed, shows more obesogenic potential, as it acts as a substrate for hepatic and adipocyte lipogenesis. High fat diet increases the absorption of LPS, which, in turn, has been found to be associated with metabolic endotoxemia and to induce inflammation resulting in obesity. Multiple independent and interrelated mechanisms have been found to be involved in such linking processes which are discussed in this review work along with some possible remedial measures for prevention of weight gain and obesity. | Chandra Kanti Chakraborti | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 22 |
| 2 | Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis显示文摘Dear Editor, In plants,the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cell types.The SWEET sugar transporter family is one such class and is represented by 17 members in Arabidopsis.AtSWEET1 was the first plant SWEET transporter to be characterized;it acts as a glucose uniporter in multiple systems (Chen et al.,2010). | Rozenn Le Hir Lara Spinner Patrick A. W. Klemens Dipankar Chakraborti Federica de Marco Francoise Vilaine Nelly Wolff Remi Lemoine Benoit Porcheron Carine Gery Evelyne Teoule Salem Chabout Gregory Mouille H. Ekkehard Neuhaus Sylvie Dinant Catherine Bellini | 2015 | Molecular Plant2015，8，11： | 16 |
| 3 | nsights into molecular therapy of glioma: current .-hallenges and next generation blueprint显示文摘Glioma 说明人的大脑肿瘤的多数。与占优势的治疗政体,病人有差的幸存率。尽管有在主流的 glioma 治疗的当前的开发,为 glioma 的痊愈看起来从活动范围。glioma 和获得的电阻的渗透性的性质 substancially 限制治疗学的选择。glioma 和 proteogenomic 描述的复杂 pathobiology 的更好的说明可能最后为更复杂、有效的联合政体的设计打开新奇大街。这能被个别地定制进步 neuroimaging 技术完成,终止有 激活prodrug 基因的 DNA 合成, silencing gliomagenesis 基因(基因治疗),指向的 miRNA oncogenic 活动( miRNA-mRNA 相互作用),有干细胞治疗的联合 Hedgehog-Gli/Akt 禁止者,作为抗原采用肿瘤 lysates 由细胞毒素的 T 淋巴细胞(树枝状的房间种痘)为肿瘤特定的癌症干细胞的有效弄空采购原料,妄想的反的采纳转移因此,现在的评论捕获与分子的机制象外科,放射和化疗的限制一样在 glial tumorigenesis 包含了联系的最近的趋势。在这篇文章,我们极其也讨论下一代为 glioma 的成功的治疗的分子的治疗学的策略和他们的机制。 | Y RAJESH Ipsita PAL Payel BANIK Sandipan CHAKRABORTY Sachin A BORKAR Goutam DEY Ahona MUKHERJEE Mahitosh MANDAL | 2017 | Acta Pharmacologica Sinica2017，38，5： | 16 |
| 4 | 液质联用(LC/MS)技术在单克隆抗体(曲妥珠单抗)结构表征上的应用显示文摘目的:应用LC/MS(液质联用)和LC/MSE方法(液相色谱/非数据依赖二级质谱数据采集方法,等频率切换高与低碰撞能量进行质谱数据扫描)对单克隆抗体(曲妥珠单抗,人源化单克隆免疫球蛋白IgG1)的结构进行深度表征。方法:先用LC/MS对曲妥珠单抗完整蛋白及其亚基(轻链和重链)的相对分子质量进行测定;然后用多种酶(胰蛋白酶和AspN)酶解蛋白并用LC/MSE肽图分析法对曲妥珠单抗的氨基酸全序列进行解析和确定,同时对可能发生的翻译后修饰(PTMs)进行定性和定量分析。再通过PNGase F酶来释放抗体上的糖链并应用LC/FLR/MS(液相色谱荧光检测与质谱联用)方法对其糖基化修饰进行结构分析及确认。结果:对曲妥珠单抗的完整蛋白及其亚基(轻链和重链)的相对分子质量测定得到良好的质量准确度,由此可判定特定蛋白修饰在轻链和重链上的分布。通过对曲妥珠单抗酶解后的氨基酸全序列确认,可对其翻译后修饰以及可能的错误氨基酸序列进行解析。该抗体肽图分析的氨基酸序列覆盖率是100%。糖基化分析是通过对游离的N-链接寡糖进行2-AB荧光标记后再用LC/FLR/MS(液相色谱荧光检测与质谱联用)方法来进行的。联合使用这些分析方法,能够有效地对不同批号和不同工艺的抗体药物进行常规质量检测和深度表征,控制药物质量,为患者提供安全可靠的生物治疗药品。结论:结合液质联用(LC/MS和LC/MSE)技术,通过完整蛋白相对分子质量的测量,肽图分析测定氨基酸序列以及翻译后修饰的定性和定量分析,结合游离N-链接寡糖的分析表征,对单克隆抗体曲妥珠单抗进行了全面的结构表征,并建立了一套单克隆抗体结构表征的平台化方案。 | Henry Shion Asish Chakraborty YU Ying-qing 陈熙 孙庆龙 Scott Berger CHEN Wei-bin 宋兰坤 | 2014 | 中国新药杂志2014，23，4： | 13 |
| 5 | Improving Multimodel Weather Forecast of Monsoon Rain Over China Using FSU Superensemble显示文摘In this paper we present the current capabilities for numerical weather prediction of precipitation over China using a suite of ten multimodels and our superensemble based forecasts. Our suite of models includes the operational suite selected by NCARs TIGGE archives for the THORPEX Program. These are: ECMWF, UKMO, JMA, NCEP, CMA, CMC, BOM, MF, KMA and the CPTEC models. The superensemble strategy includes a training and a forecasts phase, for these the periods chosen for this study include the months February through September for the years 2007 and 2008. This paper addresses precipitation forecasts for the medium range i.e. Days 1 to 3 and extending out to Day 10 of forecasts using this suite of global models. For training and forecasts validations we have made use of an advanced TRMM satellite based rainfall product. We make use of standard metrics for forecast validations that include the RMS errors, spatial correlations and the equitable threat scores. The results of skill forecasts of precipitation clearly demonstrate that it is possible to obtain higher skills for precipitation forecasts for Days 1 through 3 of forecasts from the use of the multimodel superensemble as compared to the best model of this suite. Between Days 4 to 10 it is possible to have very high skills from the multimodel superensemble for the RMS error of precipitation. Those skills are shown for a global belt and especially over China. Phenomenologically this product was also found very useful for precipitation forecasts for the Onset of the South China Sea monsoon, the life cycle of the mei-yu rains and post typhoon landfall heavy rains and flood events. The higher skills of the multimodel superensemble make it a very useful product for such real time events. | T. N. KRISHNAMURTI A. D. SAGADEVAN A. CHAKRABORTY A. K. MISHRA A. SIMON | 2009 | Advances in Atmospheric Sciences2009，26，5： | 12 |
| 6 | 关于法庭科学DNA数据库若干问题的探讨显示文摘本文论述常染色体STR基因座的选取和数量对数据库直接匹配、亲缘关系检索、失踪人员检索等数据库检索应用可能带来的影响,指出大容量DNA数据库在应用中可能出现的问题,并讨论应用数据库时需要考虑的群体和群体内差异,以及Y染色体和线粒体DNA对数据库检索的辅助作用。旨在为今后建设和完善具有中国特色的大容量DNA数据库提供参考和帮助。 | 葛建业 严江伟 Bruce Budowle Ranajit Chakraborty Arthur Eisenberg | 2011 | 中国法医学杂志2011，26，3： | 11 |
| 7 | Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity显示文摘Because of the intimate association of obesity with type 2 diabetes mellitus(T2DM), during the last two decades, extensive research work is being conducted to find out whether the coexistence of the two is a simple association or there is a positive correlating link between the two. In this article, an attempt has been made to collect and analyse the recent developments in this field and to arrive at a conclusion on the subject. The possible role of several important factors(obtained from adipocytes/not of adipocyte origin) in linking the two has been discussed in detail. Some of the agents, specifically adiponectin, are beneficial(i.e., reduce the incidence of both), while others are harmful(i.e., increase their incidence). From the analysis, it appears that obesity and T2 DM are intimately linked. | Chandra Kanti Chakraborti | 2015 | World Journal of Diabetes2015，6，15： | 11 |
| 8 | Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice显示文摘Objective:To evaluate the hepatoprotective and immunotherapeutic effects of aqueous extract of turmeric rhizome in CCl_4 intoxicated Swiss albino mice.Methods:first group of mice(n=5) received CCl_4 treatment at a dose of 0.5 mL/kg bw(i.p.) for 7 days.Second group was fed orally the aqueous extract of turmeric at a dose of 50 mg/kg bw for IS days.The third group was given both the turmeric extract(for 15 days,orally) and CCl_4(for last 7 days,i.p.).The fourth group was kept as a control.To study the liver function,the transaminase enzymes(SGOT and SGPT) and bilirubin level were measured in the serum of respective groups.For assaying the immunotherapeutic action of Curcuma longa(C.longa),non specific host response parameters like morphological alteration,phagocytosis,nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal macrophages were studied from the respective groups.Results:The result of present study suggested that CCl_4 administration increased the level of SCOT and SGPT and bilirubin level in serum.However,the aqueous extract of turmeric reduced the level of SGOT, SCFT and bilirubin in CCl_4 intoxicated mice.Apart from damaging the liver system,CCl_4 also reduced non specific host response parameters like morphological alteration,phagocytosis, nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal macrophages.Administration of aqueous extract of C.longa offered significant protection from these damaging actions of CCl_4 on the non specific host response in the peritoneal macrophages of CCl_4 intoxicated mice.Conclusions:In conclusion,the present study suggests that C.longa has immunotherapeutic properties along with its ability to ameliorate hepatotoxicity. | Mahuya Sengupta Gauri Dutta Sharma Biswajit Chakraborty | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 11 |
| 9 | 从白屈菜乙醇提取物中分离出的白屈菜碱通过p38-p53和PI3K/AKT信号转导通路促进 HeLa细胞凋亡(英文)显示文摘目的:研究从白屈菜乙醇提取物中分离出的白屈菜碱在诱导 HeLa细胞凋亡中的作用及参与其作用的主要信号转导通路。方法:细胞先以不同浓度白屈菜碱处理48h,用噻唑蓝法分析确定半数致死量(median lethal dose,LD50)。用4′,6-二脒基-2-苯基吲哚染色,追踪分析核浓染以及 DNA 损伤和碎片的形态学变化,并用流式细胞术分析检测活性氧(reactive oxygen species,ROS)的产生以及细胞周期阻滞和线粒体膜电位的变化。用圆二色光谱分析寻找白屈菜碱和小牛胸腺 DNA可能的相互作用。用逆转录聚合酶链反应和蛋白免疫印迹法测定p38、p53、蛋白激酶B(protein kinase B,AKT)、磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinases,PI3K)、Janus激酶3(Janus kinase 3,JAK3)、信号转导及转录激活因子3(signal transducer and activator oftranscription 3,STAT3)等的mRNA和蛋白表达,以及E6、E7癌基因和促凋亡基因、抗凋亡基因的mRNA和蛋白表达。结果:根据白屈菜碱的LD50(30μg/mL),选定3种实验剂量,即22.5、30和37.5μg/mL。结果显示,白屈菜碱抑制了 HeLa细胞增殖,诱发其细胞凋亡,表现为 ROS的产生,细胞亚 G1和 G0/G1周期阻滞,线粒体膜电位变化和 DNA 碎片产生。圆二色光谱分析结果显示白屈菜碱和小牛胸腺 DNA 间存在有效的相互作用。信号通路的研究显示白屈菜碱通过上调p38、p53和其他促凋亡基因的表达,以及下调 AKT、PI3K、JAK3、STAT3、E6、E7和其他抗凋亡基因的表达,有效诱发细胞凋亡。结论:从白屈菜中分离出的白屈菜碱能通过改变p38-p53及 AKT/PI3激酶信号转导通路有效地诱发 HeLa细胞凋亡。 | Avijit Paul Kausik Bishayee Samrat Ghosh Avinaba Mukherjee Sourav Sikdar Debrup Chakraborty Naoual Boujedaini Anisur Rahman Khuda-Bukhsh | 2012 | 中西医结合学报2012，10，9： | 10 |
| 10 | Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection显示文摘AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations. | Prasun Bhattacharya Partha Kumar Chandra Sibnarayan Datta Arup Banerjee Subhashish Chakraborty Krishnan Rajendran Subir Kumar Basu Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 11 | Application of response surface methodology(RSM) for optimization of leaching parameters for ash reduction from low-grade coal显示文摘Coal is the world's most abundant energy source because of its abundance and relatively low cost. Due to the scarcity in the supply of high-grade coal, it is necessary to use low-grade coal for fulfilling energy demands of modern civilization. However, due to its high ash and moisture content, low-grade coal exerts the substantial impact on their consumption like pyrolysis, liquefaction, gasification and combustion process. The present research aimed to develop the efficient technique for the production of clean coal by optimizing the operating parameters with the help of response surface methodology. The effect of three independent variables such as hydrofluoric acid(HF) concentration(10–20% by volume), temperature(60–100 °C), and time(90–180 min), for ash reduction from the low-grade coal was investigated. A quadratic model was proposed to correlate the independent variables for maximum ash reduction at the optimum process condition by using central composite design(CCD) method. The study reveals that HF concentration was the most effective parameter for ash reduction in comparison with time and temperature. It may be due to the higher F-statistics value for HF concentration, which effects to large extent of ash reduction. The characterization of coal was evaluated by Fourier transform infrared spectroscopy(FTIR) analysis and Field-emission scanning electron microscopy with energy-dispersive X-ray(FESEMEDX) analysis for confirmation of the ash reduction. | Sushanta Kumar Behera Himanshu Meena Sudipto Chakraborty B.C.Meikap | 2018 | International Journal of Mining Science and Technology2018，28，4： | 9 |
| 12 | 热改性废茶叶吸附刚果红性能的研究显示文摘采用热改性废茶叶吸附刚果红染料,考察了pH、吸附剂投加量、染料液浓度和温度对热改性废茶叶吸附染料性能的影响。采用SEM和BET研究了热改性茶叶的基本物理化学特性,最后采用伪一阶动力学模型和伪二阶动力学模型拟合了改性废茶叶对刚果红染料的吸附动力学过程,并对其吸附热力学进行分析。结果表明,热改性废茶叶表面出现了形状各异的小孔,其比表面积、总孔容和平均孔径比改性前增加较多;当溶液质量浓度为50 mg/L、pH为4、吸附剂投加量为0.4 g/L、温度为35℃时,染料的吸附率达到最佳,为98.4%,吸附量为123 mg/g;热改性废茶叶对刚果红吸附动力学符合伪二阶动力学模型,吸附过程是由物理吸附和化学吸附共同决定的。热力学分析表明,吸附过程是自发进行的吸热过程。 | 王泽怿 赵斌 沈伯雄 Sagnik Chakraborty 高兰君 | 2017 | 工业水处理2017，37，4： | 9 |
| 13 | 利用小波变换法对地震数据进行频率—时间域分解显示文摘谱分析是重要的地震信号处理工具。将地震数据变换到频率域是众多处理算法和解释方法的基础。然而,如果地震信号的频率成分随时间发生变化,那么,进行简单的一维(傅里叶)频率变换是不够的。通过滑动时窗(时间较短)可以提高频一时(FT)空间的谱分解的质量,但该方法的缺点是FT分辨率有限。最近提出的以新的小波分析数学理论为基础的变换法能避免这种分辨率的限制,进行质量更高的谱分解。与短时窗傅氏变换相比,可更好地从概念上搞清比例尺—平移平面的连续小波变换。离散小波变换和匹配追逐算法为可以选择的两种小波变换法,对地震记录成图时可将其变换到F—T空间。合成数据和经标定的炸药震源地震数据的F—T分解表明,匹配追逐算法能很好地使谱局部化,并可清地晰地分辨出反射波、直达波、面波和人为噪声。以小波变换为基础的处理算法为改进处理算法和谱解释法提供了新的机会。 | A. Chakraborty 徐焱东 | 1996 | 石油物探译丛1996，，3： | 8 |
| 14 | Deciphering codon usage patterns and evolutionary forces in chloroplast genes of Camellia sinensis var. assamica and Camellia sinensis var. sinensis in comparison to Camellia pubicosta显示文摘Codon usage bias(CUB) is a unique property of genome which refers to non-random usage of synonymous codons in coding sequences. The present study makes an attempt to find out the pattern of CUB in chloroplast(cp) genes among three tea species, i.e., Camellia sinensis var. assamica(Assam tea), Camellia sinensis var. sinensis(Chinese tea) and Camellia pubicosta(wild tea species) as no work on CUB was reported earlier. To understand the patterns of codon usage among the cp genes of three tea groups, we used bioinformatic tools to investigate the protein coding sequences of cp genes. In our present study, the mean nucleobase T was the highest whereas C was the lowest in all the three tea groups. The overall AT content was more than GC content, i.e., genes were AT rich. The scaled chi-square(SCS) value indicated that the CUB of cp genes was low. The codon CGT(Arg) was over-represented in C. sinensis var. sinensis whereas GGA(Pro) was over-represented in C. pubicosta species. Heatmap study revealed that most of the GC ending codons showed positive correlations between codon usage and GC3 while AT ending codons exhibited negative correlations. From neutrality plot analysis, it was evident that natural selection had played a major role, while mutation pressure exerted a minor effect in the CUB of cp genes in three tea groups. Highly significant(P<0.01) positive correlation was found between SCS and synonymous codon usage order(SCUO) of cp genes which suggested that high expression of cp genes was associated with high degree of CUB. | Sophiarani Yengkhom Arif Uddin Supriyo Chakraborty | 2019 | Journal of Integrative Agriculture2019，18，12： | 7 |
| 15 | Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts显示文摘Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion.CD81 cytotoxic T lymphocytes(CTLs)are involved in antigen-specific tumor destruction and CD41 T cells are essential for helping this CD81 T cell-dependent tumor eradication.Tumors often target and inhibit T-cell function to escape from immune surveillance.This dysfunction includes loss of effector and memory T cells,bias towards type 2 cytokines and expansion of T regulatory(Treg)cells.Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts.Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses.We observed severe loss of both effector and memory T-cell populations,downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors.Curcumin,in turn,prevented this loss of T cells,expanded central memory T cell(TCM)/effector memory T cell(TEM)populations,reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts.Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor(TGF)-b and IL-10 in these cells.Curcumin,however,inhibited the suppressive activity of Treg cells by downregulating the production of TGF-b and IL-10 in these cells.More importantly,curcumin treatment enhanced the ability of effector T cells to kill cancer cells.Overall,our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. | Sankar Bhattacharyya Dewan Md Sakib Hossain Suchismita Mohanty Gouri Sankar Sen Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Kaushik Das Diptendra Sarkar Tanya Das Gaurisankar Sa | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 16 | Fabrication of Bi_2O_3/TiO_2nanocomposites and their applications to the degradation of pollutants in air and water under visible-light显示文摘A nanoheterojunction composite photocatalyst Bi2O3/TiO2working under visible-light(λ 420 nm) was prepared by combining two semiconductors Bi2O3 and TiO2 varying the Bi2O3/TiO2molar ratio. Maleic acid was employed as an organic binder to unite Bi2O3 and TiO2 nanoparticles. The SEM, TEM, XRD and diffuse reflectance spectra were utilized to characterize the prepared Bi2O3/TiO2nanoheterojunction. The nanocomposite exhibited unusual high photocatalytic activity in decomposing 2-propanol in gas phase and phenol in aqueous phase and, evolution of CO2 under visible light irradiation while the end members exhibited low photocatalytic activity. The composite was optimized to 5 mol% Bi2O3/TiO2. The remarkable high photocatalytic efficiency originates from the unique relative energy band position of Bi2O3 and TiO2 as well as the absorption of visible light by Bi2O3. | Ashok Kumar Chakraborty Md Emran Hossain Md Masudur Rhaman K M A Sobahan | 2014 | Journal of Environmental Sciences2014，26，2： | 7 |
| 17 | 搅拌摩擦对接焊6061铝合金的高周疲劳行为(英文)显示文摘对6061铝合金进行搅拌摩擦对接焊,其焊接工艺参数为:旋转速度600、800、1000、1200 r/min,前进速度80、100 mm/min,探针插入深度1.85 mm。基于搅拌摩擦焊参数计算得到的能量输入结果表明,在输入能量为196~405 kJ的情况下,接头在297~354 kJ的输入能量范围内有最大的抗拉强度。在不同的应力比(R=0.5,0.3,0.1,-0.3,-0.5)下,将高强度、低强度2种焊接头进行疲劳测试。结果表明,对于这2种焊接头,显微组织特征明显影响其疲劳性能,比如搅拌区、热力影响区(TMAZ)和热影响区。从接头的显微组织、裂纹扩展路径和断裂表面观察等方面对其疲劳强度进行讨论。 | Hrishikesh DAS Debayan CHAKRABORTY Tapan KUMAR PAL | 2014 | Transactions of Nonferrous Metals Society of China2014，24，3： | 7 |
| 18 | Antimicrobial activity of Cannabis sativa,Thuja orientalis and Psidium guajava leaf extracts against methicillin-resistant Staphylococcus aureus显示文摘Objective: This study examined the antimicrobial activity of Cannabis sativa, Thuja orientalis and Psidium guajava against methicillin-resistant Staphylococcus aureus(MRSA) and used a standardized purification protocol to determine the presence and abundance of bioactive compounds in the leaf extracts.Methods: In vitro antimicrobial activities of the ethanolic extracts of C. sativa, T. orientalis and P. guajava were tested against MRSA. The presence of bioactive molecules in these three leaves was evaluated using biochemical assays and high-performance thin-layer chromatography(HPTLC).Results: Resistance to methicillin, penicillin, oxacillin and cefoxitin was observed in each of the clinical and nonclinical MRSA isolates. However, they were still vulnerable to vancomycin. Used individually,the 50% extract of each plant leaf inhibited MRSA growth. A profound synergism was observed when C. sativa was used in combination with T. orientalis(1:1) and when P. guajava was used in combination with T. orientalis(1:1). This was shown by larger zones of inhibition. This synergism was probably due to the combined inhibitory effect of phenolics present in the leaf extracts(i.e., quercetin and gallic acid)and catechin, as detected by HPTLC.Conclusion: The leaf extracts of C. sativa, T. orientalis and P. guajava had potential for the control of both hospital-and community-acquired MRSA. Moreover, the inhibitory effect was enhanced when extracts were used in combination. | Shohini Chakraborty Nashra Afaq Neelam Singh Sukanta Majumdar | 2018 | Journal of Integrative Medicine2018，16，5： | 7 |
| 19 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 20 | Sequencing a Juglans regia×J.microcarpa hybrid yields high-quality genome assemblies of parental species显示文摘Members of the genus Juglans are monecious wind-pollinated trees in the family Juglandaceae with highly heterozygous genomes,which greatly complicates genome sequence assembly.The genomes of interspecific hybrids are usually comprised of haploid genomes of parental species.We exploited this attribute of interspecific hybrids to avoid heterozygosity and sequenced an interspecific hybrid Juglans microcarpa×J.regia using a novel combination of single-molecule sequencing and optical genome mapping technologies.The resulting assemblies of both genomes were remarkably complete including chromosome termini and centromere regions.Chromosome termini consisted of arrays of telomeric repeats about 8 kb long and heterochromatic subtelomeric regions about 10 kb long.The centromeres consisted of arrays of a centromere-specific Gypsy retrotransposon and most contained genes,many of them transcribed.Juglans genomes evolved by a whole-genome-duplication dating back to the Cretaceous-Paleogene boundary and consist of two subgenomes,which were fractionated by numerous short gene deletions evenly distributed along the length of the chromosomes.Fractionation was shown to be asymmetric with one subgenome exhibiting greater gene loss than the other.The asymmetry of the process is ongoing and mirrors an asymmetry in gene expression between the subgenomes.Given the importance of J.microcarpa×J.regia hybrids as potential walnut rootstocks,we catalogued disease resistance genes in the parental genomes and studied their chromosomal distribution.We also estimated the molecular clock rates for woody perennials and deployed them in estimating divergence times of Juglans genomes and those of other woody perennials. | Tingting Zhu Le Wang Frank M.You Juan C.Rodriguez Karin R.Deal Limin Chen Jie Li Sandeep Chakraborty Bipin Balan Cai-Zhong Jiang Patrick J.Brown Charles ALeslie Mallikarjuna KAradhya Abhaya M.Dandekar Patrick E.McGuire Daniel Kluepfel Jan Dvorak Ming-Cheng Luo | 2019 | Horticulture Research2019，6，1： | 7 |
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