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| 1 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 2 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 3 | Transgenic mice and knockout mutants in the study of oxidative stress in brain injury显示文摘 | Chan P H Epstein C J Li Y | 1995 | J Neurotrauma1995，12，5： | 2 |
| 4 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 5 | Polymerase chain reaction enzyme-linked immunosorbent assay detection of mycoplasma consensus gene in sperm with low oocyte penetration capacity 显示文摘 | Kalugdan T Chan P J S eraj IM | 1996 | Journal Article Fertility and Sterility1996，66，5： | 1 |
| 6 | Relationship between high-grade lymphoma and low-grade B-cell MALTorna of the stomach显示文摘 | CHAN J K C NG C S ISAACSON P G | 1990 | Am J Pathol1990，136，： | 1 |
| 7 | Factor analysis of the metabolic syndrome:obesity vs insulin resistance as the central abnormality 显示文摘 | Anderson P J Critchley JA Chan Jc | 2001 | Int J Obes Relat Metab Disord2001，25，12： | 1 |
| 8 | Supervised learning of semantic classes for image annotation and retrieval 显示文摘 | Carneiro G Chan A B Moreno P J | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，3： | 1 |
| 9 | Surgical and visual outcomes of the type I Boston Kera- toprosthesis for the management of aniridic fibrosis syndrome in congenital aniridia 显示文摘 | Bakhtiari P Chan C Welder JD de la Cruz J Holland E J Djalil- ian AR | 2012 | Am J Ophthalmol2012，153，5： | 1 |
| 10 | PPAR agonists modulate human osteoclast formation and activity in vitro显示文摘 | Chan BY Gartland A Wilson P J | 2007 | Bone2007，40，： | 1 |
| 11 | Deficits in saccadic eye-movement control in Parkinson's disease 显示文摘 | Chan F Armstrong IT Pari G Riopelle P J Munoz DE 2005 | 2005 | Neuropsychologia2005，43，： | 1 |
| 12 | Neuroprotection by interleukin 6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in isehemic stroke 显示文摘 | JUNG J E KIM G S CHAN P H | 2011 | Stroke2011，42，12： | 1 |
| 13 | Undergraduate Medical Education:Comparison of Problem-based Learning and Conventional Teaching显示文摘 | Nandi P L Chan J N F Chan C P K | 2000 | HKMJ2000，6，3： | 1 |
| 14 | Systems for knowledge discovery in databases显示文摘 | MATHEUS C J CHAN P K PIATETSKY- SHAPIRO G | 1993 | IEEE Transactions on Knowledge and Data Engineering1993，5，6： | 1 |
| 15 | Synthesizing two character interactions by merging captured interaction samples with their spacetime relationships显示文摘 | Chan J C P Tang J K T Leung H | 2013 | Computer Graphics Forum2013，32，7： | 1 |
| 16 | Update on HIV dementia and HIV-associated neuroeog-nitive disorders显示文摘 | Brew B J Chan P | 2014 | Curr Neurol Neurosci Rep2014，14，8： | 1 |
| 17 | Human copper-zinc superoxide Dismutase transgenic mice are highly resistant to reperfusion in- jury after focal cerebral ischemia Stroke显示文摘 | Yang G P H Chan J Chert | 1994 | A journal of cerebral circulation1994，25，1： | 1 |
| 18 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 19 | MRI of joint fluid in femoral head osteonecrosis 显示文摘 | CHAN W P LIU Y J HUANG G S | 2003 | Skeletal Radiol2003，31，11： | 1 |
| 20 | Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma显示文摘 | Chan J L Tang K C Patel A P | 2006 | Blood2006，107，： | 1 |
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